Claims for Patent: 7,662,552
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Summary for Patent: 7,662,552
Title: | Method of diagnosing and treating lesion of crystalline lens using human CRYGS gene and coding product thereof |
Abstract: | The method of diagnosing lesions of crystalline lens such as cataract is disclosed. It comprises detecting variation of crygs gene, transcript and/or protein of individuals compared with normalty. The individual suffers from cataract more possible than normalty when occurring the variation. The present invention also discloses the method and pharmaceutical composition of treating lesions of crystalline lens such as cataract. |
Inventor(s): | Kong; Xiangyin (Shanghai, CN), Bu; Lei (Shanghai, CN), Zhao; Guoping (Shanghai, CN), Yan; Shunsheng (Shanghai, CN), Jin; Meilei (Shanghai, CN), Sulitang; Yerjiang (Shanghai, CN), Jin; Yiping (Shanghai, CN), Hu; Liandian (Shanghai, CN) |
Assignee: | Shanghai Institutes of Biological Science, Chinese Academy of Sciences (Shanghai, CN) |
Application Number: | 10/362,817 |
Patent Claims: | 1. A method for determining the cataract susceptibility in a subject comprising the steps of: a) obtaining a biological sample from said subject, said biological sample
comprising nucleic acids from the subject; b) detecting in said nucleic acids the subject's gamma-S crystalline (CRYGS) gene and determining the nucleic acid sequence of the subject's gamma-S crystalline (CRYGS) gene; c) detecting in the nucleic acid
sequence of the subject's gamma-S crystalline (CRYGS) gene homozygous nucleotide content comprising: i) a C at position 424 of SEQ ID NO: 30 resulting from a G to C change at position 76 of intron 1; ii) a G at position 357 of SEQ ID No: 31 resulting
from an A to G change at position 11 of intron 2; iii) the sequence ATGTATGT, wherein the first position of the sequence is at position 366 of SEQ ID NO: 31, resulting from a repeat of the ATGT sequence at positions 20-23 of intron 2; and iv) an A at
position 1398 of SEQ ID NO: 31 resulting from a G to A change at position 225 of exon 3; wherein said subject is a mouse and said nucleoticle content indicates an increased cataract susceptibility.
2. The method of claim 1, wherein the CRYGS gene is detected with a primer or probe. 3. The method of claim 2, wherein the primer or probe detects a difference selected from the group consisting of: i) a C at position 424 of SEQ ID NO: 30 resulting from a G to C change at position 76 of intron 1; ii) a G at position 357 of SEQ ID NO: 31 resulting from an A to G change at position 11 of intron 2; iii) the sequence ATGTATGT, wherein the first position of the sequence is at position 366 of SEQ ID NO: 31, resulting from a repeat of the ATGT sequence at positions 20-23 of intron 2; and iv) an A at position 1398 of SEQ ID NO: 31 resulting from a G to A change at position 225 of exon 3. |
Details for Patent 7,662,552
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | 06/04/1986 | ⤷ Try a Trial | 2020-08-25 |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | ⤷ Try a Trial | 2020-08-25 | |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | Injection | 103132 | ⤷ Try a Trial | 2020-08-25 | |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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