Last Updated: May 10, 2026

Claims for Patent: 7,595,048

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Summary for Patent: 7,595,048

Title:	Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1
Abstract:	Compositions for cancer or infection treatment via immunopotentiation caused by inhibition of the immunosuppressive signal induced by PD-1, PD-L1, or PD-L2 and therapies using them, immunopotentiative substrates included as the active ingredient, screening methods of the substrates for cancer or infection treatment, cell lines used for the screening methods, evaluation methods that select the substrates for cancer treatment, and carcinoma cell transplanted mammals used for the evaluation methods. The compositions of the present invention that inhibit the function of PD-1, PD-L1, or PD-L2 are useful for treatment of cancer or infection.
Inventor(s):	Tasuku Honjo, Nagahiro Minato, Yoshiko Iwai, Shiro Shibayama
Assignee:	Ono Pharmaceutical Co Ltd , Dana Farber Cancer Institute Inc
Application Number:	US10/519,925

Details for Patent 7,595,048

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bristol-myers Squibb Company	OPDIVO	nivolumab	Injection	125554	December 22, 2014	⤷ Start Trial	2023-07-02
Bristol-myers Squibb Company	OPDIVO	nivolumab	Injection	125554	October 04, 2017	⤷ Start Trial	2023-07-02
Bristol-myers Squibb Company	OPDIVO	nivolumab	Injection	125554	August 27, 2021	⤷ Start Trial	2023-07-02
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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