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Generated: August 21, 2019

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Claims for Patent: 7,547,546

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Summary for Patent: 7,547,546
Title:Progenitor cells from wharton\'s jelly of human umbilical cord
Abstract: Human progenitor cells are extracted from perivascular tissue of human umbilical cord. The progenitor cell population proliferates rapidly, and harbours osteogenic progenitor cells and MHC-/- progenitor cells, and is useful to grow and repair human tissues including bone.
Inventor(s): Davies; John E. (Toronto, CA), Baksh; Dolores (Mississauga, CA), Sarugaser; Rahul (Toronto, CA), Hosseini; Morris (Braunschweig, DE), Lickorish; Antony D. S. (Toronto, CA)
Assignee: Tissue Regeneration Therapeutics Inc. (Toronto, Ontario, CA)
Application Number:10/961,919
Patent Claims:1. A method of obtaining a population of human umbilical cord perivascular (HUCPV) cells, comprising: (a) obtaining an excised blood vessel from human umbilical cord comprising the perivascular region of said vessel; and (b) treating said blood vessel by enzymatic digestion of the perivascular region and isolating a population of HUCPV cells that comprise an MHC.sup.-/- phenotype from said digested perivascular region.

2. The method according to claim 1, wherein the enzymatic digestion is performed using collagenase.

3. The method according to claim 2, wherein the enzymatic digestion is performed at 37.degree. C. in phosphate buffered saline and 0.1-10.0 mg/mL collagenase for a period of 1 to 24 hours.

4. The method according to claim 1, further comprising culturing said population of HUCPV cells to expand the population thereof.

5. The method according to claim 1, further comprising cryopreserving the population of HUCPV cells.

6. The method according to claim 4, further comprising cryopreserving the expanded population of HUCPV cells.

Details for Patent 7,547,546

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Advance Biofactures SANTYL collagenase VIAL 101995 001 1965-06-04   Try a Free Trial Tissue Regeneration Therapeutics Inc. (Toronto, Ontario, CA) 2023-02-11 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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