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Last Updated: April 26, 2024

Claims for Patent: 7,459,546

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Summary for Patent: 7,459,546

Title:	Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase regulatory sequences for gene expression in oleaginous yeast
Abstract:	The regulatory sequences associated with the Yarrowia lipolytica glyceraldehyde-3-phosphate dehydrogenase (gpd) and phosphoglycerate mutase (gpm) genes have been found to be particularly effective for the expression of heterologous genes in oleaginous yeast. The promoter regions of the invention, intron and enhancer have been shown to drive high-level expression of genes involved in the production of .omega.-3 and .omega.-6 fatty acids.
Inventor(s):	Picataggio; Stephen K. (Landenberg, PA), Zhu; Quinn Qun (West Chester, PA)
Assignee:	E.I. du Pont de Nemours and Company (Wilmington, DE)
Application Number:	11/183,664
Patent Claims:	1. An isolated nucleic acid molecule comprising the intron of the Yarrowia gpd gene as set forth in SEQ ID NO:97. 2. A plasmid comprising the gpd intron of claim 1.

Details for Patent 7,459,546

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2023-06-25
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2023-06-25
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2023-06-25
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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