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Last Updated: April 26, 2024

Claims for Patent: 7,378,495

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Summary for Patent: 7,378,495

Title:	PTH-rP related peptide cancer therapeutics
Abstract:	Compositions comprising PTH-rP peptides, combinations thereof, and multiepitope PTH-rP peptides, vectors for their delivery to antigen presenting cells, as well as methods are provided which are useful in the immunotherapy of parathyroid hormone related peptide expressing malignancies.
Inventor(s):	Correale; Pierpaolo (Siena, IT), Cusi; Maria Grazia (Siena, IT), Francini; Guido (Siena, IT)
Assignee:	Pevion Biotech, Ltd. (Bern, CH)
Application Number:	10/691,125
Patent Claims:	1. An isolated immunostimulatory parathyroid hormone-related (PTH-rP) peptide consisting of an amino acid sequence selected from the group consisting of SEQ ID NO:3, SEQ ID NO:4 and SEQ ID NO:5. 2. An immunostimulatory peptide comprising a T helper epitope linked to an amino acid sequence selected from the group consisting of SEQ ID NO:3. SEQ ID NO:4 and SEQ ID NO:5. 3. An isolated immunostimulatory peptide consisting of two or more amino acid sequences selected from the group consisting of SEQ ID NO:3, SEQ ID NO:4 and SEQ ID NO:5. 4. The peptide of claim 3 wherein the amino acid sequences are arranged in sequential or concatameric. 5. An immunostimulatory peptide comprising a T helper epitope linked to two or more amino acid sequence selected from the group consisting of SEQ ID NO:3, SEQ ID NO:4 and SEQ ID NO:5. 6. A composition comprising a virosome encapsulating the immunostimulatory peptide of any one of claims 1, 2, 3, or 5. 7. A composition comprising a virosome crosslinked to the immunostimulatory peptide of any one of claims 1, 2, 3, or 5. 8. A kit comprising the PTH-rP peptide of any one of claims 1, 2, 3, or 5 and instructions for use.

Details for Patent 7,378,495

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015	⤷ Try a Trial	2022-10-21
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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