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Last Updated: May 10, 2024

Claims for Patent: 7,348,009

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Summary for Patent: 7,348,009

Title:	Recombinant allergen with reduced enzymatic activity
Abstract:	The present invention provides a novel treatment for allergy comprising a recombinant allergen with reduced enzymatic activity, thereby reducing the potential for an allergic response upon contact with a wild-type allergen.
Inventor(s):	Bruck; Claudine (Rixensart, BE), Bollen; Alex (Itterbeek, BE), Jacobs; Paul (Lanquesaint, BE), Massaer; Marc Georges Francis (Braine le Chateau, BE)
Assignee:	SmithKline Beecham Biologicals, s.a. (Rixensart, BE)
Application Number:	09/554,860
Patent Claims:	1. A recombinant mutant pro-DerP1 allergen of the DerP1 pre-pro-protein of SEQ ID NO: 1 wherein SEQ ID NO: 1 comprises a cysteine to alanine substitution at amino acid position 132 and wherein said pro-DerP1 allergen is from Dermatophagoides pteronyssinus. 2. A therapeutic formulation comprising the recombinant mutant pro-DerP1 allergen as claimed in claim 1 and an adjuvant. 3. The therapeutic formulation as claimed in claim 2, wherein the adjuvant is a preferential stimulator of the Th1-type immune response. 4. The therapeutic formulation as claimed in claim 2, wherein the adjuvant comprises at least one selected from the group consisting of QS21 and 3-O-deacylated monophosphoryl lipid A.

Details for Patent 7,348,009

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Greer Laboratories, Inc.	N/A	insects (whole body), mite dermatophagoides pteronyssinus	Injection	101835	09/15/1958	⤷ Try a Trial	2017-11-19
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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