Last Updated: May 11, 2026

Claims for Patent: 7,332,480

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Summary for Patent: 7,332,480

Title:	Compositions for the regulation of cytokine activity
Abstract:	Substances comprising carboxylated and/or sulfated oligosaccharides in substantially purified form, including compositions containing same and methods of using same, are disclosed for the regulation of cytokine activity in a host. For instance, the secretion of Tumor Necrosis Factor Alpha (TNF-α) can be either inhibited or augmented selectively by administration to the host of effective amounts of substances or their compositions comprising specific oligosaccharides in substantially purified form. Thus, the present invention also relates to pharmaceutical compositions and their use for the prevention and/or treatment of pathological processes involving the induction of active cytokine secretion, such as TNF-α. The invention also relates to the initiation of a desirable immune system-related response by the host to the presence of activators, including pathogens. The substances and pharmaceutical compositions of the present invention may be daily, at very low effective doses, typically below 0.1 mg/kg human, or at intervals of up to about 5-8 days, preferably once a week.
Inventor(s):	Irun R. Cohen, Ofer Lider, Liora Cahalon, Oded Shoseyov, Raanan Margalit
Assignee:	Yeda Research and Development Co Ltd
Application Number:	US10/831,288

Details for Patent 7,332,480

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Sanofi-aventis U.s. Llc	ADMELOG	insulin lispro	Injection	209196	December 11, 2017	⤷ Start Trial	2024-04-26
Sanofi-aventis U.s. Llc	ADMELOG	insulin lispro	Injection	209196	October 19, 2018	⤷ Start Trial	2024-04-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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