Claims for Patent: 7,268,110

Summary for Patent: 7,268,110

Title:	Agents for preventing and treating thrombocytopenia
Abstract:	Method of increasing blood platelet formation by administering a parathyroid hormone (PTH) or at least one PTH derivative as an active ingredient.
Inventor(s):	Tamura; Masahiko (Shizuoka-ken, JP), Oda; Yasuhiro (Nagano-ken, JP)
Assignee:	Chugai Seiyaku Kabushiki Kaisha (Tokyo, JP)
Application Number:	11/110,852
Patent Claims:	1. A method for increasing platelet counts in a patient in need thereof, comprising administering to said patient a platelet-increasing effective amount of a composition comprising a parathyroid hormone (PTH) or a derivative thereof having a platelet-increasing activity similar to that of PTH, wherein said PTH or PTH derivative is selected from the group consisting of human PTH (1-34), human PTH (1-64), human PTH (35-84), bovine PTH (1-34), human PTH (1-84), human PTH (1-38) and human PTH (1-37), wherein said PTH or said PTH derivative optionally further comprises one or more of the following substitutions: (1) substitution of leucine or norleucine at the 8-position, (2) substitution of leucine or norleucine at the 18-position, and (3) substitution of tyrosine at the 34-position, and wherein said patient is a patient suffering from thrornbocytopenia purpura, selective suppression of megakaryocytes, a viral infection, aplastic anemia, osteomyelodysplasis syndrome, leukemia or multiple myeloma. 2. The method according to claim 1 wherein said patient is a patient suffering from thrombocytopenia purpura. 3. The method according to claim 1 wherein said patient is a patient suffering from selective suppression of megakaryocytes. 4. The method according to claim 1 wherein said patient is a patient suffering from a viral infection. 5. The method according to claim 1 wherein said patient is a patient suffering from aplastic anemia. 6. The method according to claim 1 wherein said patient is a patient suffering from osteomyelodysplasis syndrome. 7. The method according to claim 1 wherein said patient is a patient suffering from leukemia. 8. The method according to claim 1 wherein said patient is a patient suffering from multiple myeloma. 9. A method for increasing platelet count in a patient in need thereof, comprising administering to said patient a platelet-increasing effective amount of a composition comprising a parathyroid hormone (PTH) or a derivative thereof having a platelet-increasing activity similar to that of PTH, wherein said PTH or PTH derivative is selected from the group consisting of human PTH (1-34), human PTH (1-64), human PTH (35-84), bovine PTH (1-34), human PTH (1-84), human PTH (1-38) and human PTH (1-37), wherein said PTH or said PTH derivative optionally further comprises one or more of the following substitutions: (1) substitution of leucine or norleucine at the 8-position, (2) substitution of leucine or norleucine at the 18-position, and (3) substitution of tyrosine at the 34-position, and wherein said patient is a patient who has been or is being treated with at least one of phenylbutazone, gold compounds, tolbutamide or a chemotherapeutic. 10. A method for increasing platelet count in a patient in need thereof, comprising administering to said patient a platelet-increasing effective amount of a composition comprising a parathyroid hormone (PTH) or a derivative thereof having a platelet-increasing activity similar to that of PTH, wherein said PTH or PTH derivative is selected from the group consisting of human PTH (1-34), human PTH (1-64), human PTH (35-84), bovine PTH (1-34), human PTH (1-84), human PTH (1-38) and human PTH (1-37), and wherein said PTH or said PTH derivative optionally further comprises one or more of the following substitutions: (1) substitution of leucine or norleucine at the 8-position, (2) substitution of leucine or norleucine at the 18-positon, and (3) substitution of tyrosine at the 34-position.

Details for Patent 7,268,110

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015		2016-02-01