Claims for Patent: 7,186,753
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Summary for Patent: 7,186,753
Title: | Pharmaceutical compounds |
Abstract: | Compounds or their salts of general formula (I): A--B--N(O).sub.s wherein: s is an integer equal to 1 or 2; A=R--T.sub.1--, wherein R is the drug radical and T.sub.1=(CO).sub.t or (X).sub.t\', wherein X=O, S, NR.sub.1c, R.sub.1c is H or a linear or branched alkyl or a free valence, t and t\' are integers and equal to zero or 1, with the proviso that t=1 when t\'=0; t=0 when t\'=1; B=--T.sub.B--X.sub.2--O-- wherein T.sub.B=(CO) when t=0, T.sub.B=X when t\'=0, X being as above defined; X.sub.2 is equal to R.sub.1B--X--R.sub.2B radical wherein X is as above defined, R.sub.1B and R.sub.2B, equal to or different from each other, are linear or branched C.sub.1 C.sub.6 alkylenes, or X.sub.2 is a radical wherein two alkylene chains C.sub.1 C.sub.4 are linked to nonadjacent positions of a central ring having 4 or 6 atoms, said ring being an unsaturated cycloaliphatic ring, or a saturated or aromatic heterocylic ring, containing one or two heteroatoms, equal or different, selected from O, S, N; wherein the unsaturated cycloaliphatic ring does not have aromatic character according to Huckel\'s rule. |
Inventor(s): | Del Soldato; Piero (Milan, IT) |
Assignee: | Nicox S.A. (Sophia Antipolis, FR) |
Application Number: | 10/048,469 |
Patent Claims: | 1. Compounds or their salts having the following general formula (I): A--B--N(O).sub.s (I) wherein: s is an integer equal to 1 or 2; A=R--T.sub.1--, wherein R is a
drug radical wherein the drug is selected from the following: anti-inflammatory drugs: sulindac; analgesic drugs: acetaminophen, acetaminosalol, aminochlorthenoxazin, acetylsalicylic 2-amino-4-picoline acid, acetylsalicylsalicylic acid, anileridine,
benoxaprofen benzylmorphine, 5-bromosalicylic acetate acid, bucetin, buprenorphine, butorphanol, capsaicine, cinchophen, ciramadol, clometacin, clonixin, codeine, desomorphine, dezocine, dihydrocodeine, dihydromorphine, dimepheptanol, dipyrocetyl,
eptazocine, ethoxazene, ethylmorphine, eugenol, floctafenine, fosfosal, glafenine, hydrocodone, hydromorphone, hydroxypethidine, ibufenac, plactophenetide, levorphanol, meptazinol, metazocine, metopon, morphine, nalbuphine, nicomorphine, norlevorphanol,
normorphine, oxycodone, oxymorphone, pentazocine, phenazocine, phenocoll, phenoperidine, phenylbutazone, phenylsalicylate, phenylramidol, salicin, salicylamide, tiorphan, tramadol, diacerein, actarit; broncodilators and drugs active on the cholinergic
system: acefylline, albuterol, bambuterol, bamifylline, bevonium methyl sulphate, bitolterol, carbuterol, clenbuterol, chlorprenaline, dioxethedrine, difylline, ephedrine, epinephrine, eprozinol, etafredine, ethylnorepinephrine, etofylline, fenoterol,
flutoprium bromide, hexoprenaline, ipratropium bromide, isoetharine, isoprotenerol, mabuterol, metaproterenol, oxybutinyn, oxitropium bromide, pirbuterol, procaterol, protokylol, proxyphylline, reproterol, rimiterol, salmeterol, soterenol, terbutaline,
1-teobromineacetic acid, tiotropium bromide, tretoguinol, tulobuterol, zaprinast, cyclodrine, NS-21, 2-hydroxy-2,2,diphenyl-N-(1,2,3,6-tetrahydro-pyridin-4-ylmethyl)acetamide- ; expectorant/mucolytic drugs: acetil-cysteine, ambroxol, bromhexine,
carbocysteine, domiodol, erdosteine, ferulic acid, guaiacol, guaifenesin, iodinated glycerol, letosteine, mecysteine hydrochloride, mesna, sobrerol, stepronin, terpin, tiopronin; antiasthmatic/antiallergic antihistaminic drugs: acrivastine, alloclamide,
amlexanox, cetirizine, clobenzepam, chromoglycate, chromolyn, epinastine, fexofenadine, formoterol, histamine, hydroxyzine, levocabastine, lodoxamide, mabuterol, metrons, montelukast, nedocromil, repirinast, seratrodast, suplatast tosylate, terfenadine,
tiaramide, urushiol, bromhexine: antithrombotic and vasoactive drugs: acetorphan, argatroban, bamethan, benfurodil hemisuccinate, benziodarone, betahistine, brovincamine, bufeniode, citicoline, clobenfurol, clopidogrel, cyclandelate, dalteparin,
dipyridamole, droprenilamine, enoxaparin, fendiline, ifenprodil, iloprost, indobufen, isbogrel, isoxsuprine, heparin, lamifiban, midodrine, nadroparin, nicotinyl alcohol, nylidrin, ozagrel, perhexiline, phenylpropanolamine, prenylamine, papaveroline,
reviparin sodium salt, ridogrel, suloctidil, tinofedrine, tinzaparin, triflusal, xanthinol niacinate; antidiabetic drugs: acarbose, carbutamide, glibornuride glybuthiazol(e), miqlitol, repaglinide, troglitazone, 1-butyl-3-metanyl-urea, tolrestat,
nicotinamide: antitumoral drugs: ancitabine, anthramycin, azacitidine, azaserine, 6-azauridine, bicalutamide, carubicin, carzinophilin, chlorambucil, chlorozotocin, cytarabine, daunorubicin, defosfamide, demecolcine, denopterin,
6-diazo-5-oxo-L-norleucine, docetaxel, doxifluridine, doxorubicin, droloxifene, edatrexate, eflornithine, enocitabine, epirubicin, epitiostanol, etanidazole, etoposide, fenretinide, fludarabine, fluorouracil, gemcitabine, hexestrol, idarubicin,
lonidamine, mannomustine, melphalan, menogaril, 6-mercaptopurine, methotrexate, mitobronitol, mitolactol, mitomycins, mitoxantrone, mopidamol, mycophenolic acid, ninopterin, nogalamycin, paclitaxel, pentostatin, pirarubicin, piritrexim, plicamycin,
podopillic acid, porfimer sodium, porfiromycin, propagermanium, puromycin, ranimustine, retinoic acid, roquinimex, streptonigrin, streptozocin, teniposide, tenuazonic acid, thiamiprine, thioguanine, tomudex, topotecan, trimetrexate, tubercidin, ubenimex,
vinblastine, vincristine, vindesine, vinorelbine, zorubicin; antiulcer drugs: acetamidocaproic acid, arbaprostil, cetraxate, cimetidine, ecabet, enprostil, esaprazole, irsogladine, misoprostol, omeprazole, ornoprostil, pantoprazole, plaunotol,
rioprostil, rosaprostol, rotraxate, sofalcone, trimoprostil; anti-hyperlipidemic drugs: atorvastatin, cilastatin, dermostatin, fluvastatin, lovastatin, mevastatin, nystatin, pentostatin, pepstatin, pravastatin sodium, simvastatin; antibiotics:
amdinocillin, amoxicillin, ampicillin, apalcillin, apicycline, aspoxicillin, azidamfenicol, azidocillin, aziocillin, aztreonam, benzoylpas, benzyl penicillinic acid, biapenem, bicozamycin, capreomycin, carbenicillin, carindacillin, carumonam, cefaclor,
cefadroxil, cefamandole, cefatrizine, cefazedone, cefazolin, cefbuperazone, cefclidin, cefdinir, cefditoren, cefepime, cefetamet, cefixime, cefinenoxime, cefinetazole, cefminox, cefodizime, cefonicid, cefoperazone, ceforanide, cefotaxime, cefotetan,
cefotiam, cefoxitin, cefozopran, cefpimizole, cefpiramide, cefpirome, cefprozil, cefroxadine, cefsulodin, ceftazidime, cefteram, ceftezole, ceftibuten, ceftiofur, ceftizoxime, ceftriaxone, cefuroxime, cefuzonam, cephacetrile sodium, cephalexin,
cephaloglycin, cephaloridine, cephalosporin C, cephalothin, cephapirin sodium, cephradine, chloramphenicol, chlortetracycline, cinoxacin, cyprofloxacin, clavulanic acid, clometocillin, cloxacillin, cyclacillin, cycloserine, demeclocycline, dicloxacillin,
epicillin, fenbecillin, flomoxef, floxacilli-n, hetacillin, imipenem, lenampicillin, loracarbef, lymecycline, mafenide, meclocycline, meropenem, metampicillin, methacycline, methicillin sodium, meziocillin, minocycline, moxalactam, mupirocin, myxin,
negamycin, novobiocin, oxacillin, panipenem, penicillin G potassium salt, penicillin N, penicillin O, penicillin V, phenethicillin potassium salt, pipacycline, piperacillin, pirlimycin, porfiromycine, propicillin, quinacillin, ritipenem,
rolitetracycline, sancycline, sedecamycine, spectinomycin, sulbactam, sulbenicillin, temocillin, tetracycline, ticarcillin, tigemonam, tubercidin, azithromycin, clarithromycin, dirithromycin, enviomycin, erythromycin, iosamycin, midecamycin, miokamycin,
oleandomycin, rifabutin, rifamide, rifamycin, rifaximin, rokitamycin, spiramycin, troleandromycin, viomycin, virginiamycin; amikacin, apramycin, arbekacin, dibekacin, dihydrostreptomycin, fortimicins, gentamicin, micronomicin, neomycin, netilmicin,
paromomycin, ribostamycin, sisomicin, spectinomycin, streptomicin, tobramycin, trospectomycin; bacampicillin, cefcapene pivoxil, cefpodoxime proxetil, panipenem, pivampicillin, pivcefalexin, sultamicillin, talampicillin; carbomycin, clindamycin,
lincomycin, mikamycin, rosaramicin, ciprofloxacin, clinafloxacin, difloxacin, enoxacin, enrofloxacin, fieroxacin, flumequine, grepafloxacin, lomefloxacin, nadifloxacin, nalidixic acid, norfloxacin, ofloxacin, pazufloxacin, pefloxacin, pipemidic acid,
piromidic acid, rufloxacin, sparfloxacin, tosufloxacin, trovafloxacin, clomocycline, quamecycline, oxytetracycline, nifurpirinol, nifurprazine; p-aminosalicylic acid, p-aminosalicylic acid hydrazide, clofazimine, deoxydihydrostreptomycin, ethambutol,
qlyconiazide, isoniazid, opiniazide, phenyl aminosalicylate, rifampin, rifapentine, salinazid, 4-4'-sulfynyldianiline, acediasulfone, dapsone, succisulfone, p-sulfanilylbenzyl amine, thiazolsulfone, acetyl sulfamethoxypyrazine, mafenide,
4'-(methylsulfamoyl)sulfanilanilide, salazosulfadimidine, sulfabenzamide, sulfacetamide, sulfachlorpyridazine, sulfachrysoidine, sulfacytine, sulfadiazine, sulfadicramide, sulfadimethoxine, sulfadoxine, sulfaethidole, sulfaguanidine, sulfaguanole,
sulfalene, sulfamerazine, sulfameter, sulfamethazine, sulfamethizole, sulfamethomidine, sulfamethoxazole, sulfamethoxypyridazine, sulfamethylthiazole, sulfametrole, sulfamidochrysoidine, sulfamoxole, sulfanilamide, 2-psulfanilylanilinoethanol,
N.sup.4-sulfanilylsulfanilamide, sulfanilylurea, N-sulfanilyl-3,4-xylamide, sulfaperine, sulfaphenazole, sulfaproxyline, sulfapyrazine, sulfapyridine, sulfasomizole, sulfasymazine, sulfathiazole, sulfathiourea, sulfisomidine, sulfisoxazole,
4-sulfanilamido salicylic acid: negamycin, carumonan, cloxyguin, nitroxoline, arginine, metronidazole; antiviral drugs: acyclovir, amantadine, cidofovir, cytarabine, didanosine, dideoxyadenosine, edoxudine, famciclovir, floxuridine, ganciclovir,
idoxuridine, indanavir, kethoxal, lamivudine, MADU, penciclovir, podophyllotoxin, ribavirin, rimantadine, saguinavir, sorivudine, stavudine, trifluridine, valacyclovir, vidarabine, xenazoic acid, zalcitabine, zidovudine; bone resorption inhibitors:
alendronic acid, butedronic acid, etidronic acid, oxidronic acid, pamidronic acid, risedronic acid; antidementia drugs: amiridine, lazabemide, mofegiline, salbeluzol, oxiracetam, ipidacrine, nebracetam, tacrine, velnacrine; and T.sub.1=(CO).sub.t or
(X).sub.t', wherein X.dbd.O, S, NR.sub.1C, R.sub.1C is H or a linear or branched alkyl, having from 1 to 6 carbon atoms, or a free valence, t and t' are integers and equal to zero or 1, with the proviso that t=1 when t'=0; t=0 when t'=1;
B=--T.sub.B--X.sub.2--O-- wherein T.sub.B=(CO) when t=0, T.sub.B=X when t'=0, X being as above defined; X.sub.2 equal to R.sub.1B--X--R.sub.2B radical wherein X is as above defined, R.sub.1B and R.sub.2B, equal to or different from each other, are
linear or branched C.sub.1 C.sub.6 alkylenes, or X.sub.2 is a radical wherein two alkylene chains C.sub.1 C.sub.4 are linked to nonadjacent positions of a central ring having 4 or 6 atoms, said ring being an unsaturated cycloaliphatic ring, or a
saturated or aromatic heterocylic ring, containing one or two heteroatoms, equal or different, selected from O, S, N; wherein the unsaturated cycloaliphatic ring does not have aromatic character according to Huckel's rule.
2. Compounds according to claim 1, wherein the precursor compounds of B are: 1,4-butandiol: HO--(CH.sub.2).sub.4--OH, 6-hydroxyhexanoic acid: HO--(CH.sub.2).sub.5--COOH, 4-hydroxybutyric acid: HO--(CH.sub.2).sub.3--COOH, N-methyldiethanolamine: HO--(CH.sub.2).sub.2--N(CH.sub.3)--(CH.sub.2).sub.2--OH, diethylenglycol: HO--(CH.sub.2).sub.2--O--(CH.sub.2).sub.2--OH, thiodiethylenglycol: HO--(CH.sub.2).sub.2--S--(CH.sub.2).sub.2--OH; 1,4 dioxane-2,6-dimethanol, tetrahydropyrane-2,6-dimethanol, 4H pyrane-2,6-dimethanol, tetrahydrothiopyrane-2,6-dimethanol, 1,4-dithiane-2,6-dimethanol, cyclohexene-1,5-dimethanol, thiazole-2,5-dimethanol, thiophene-2,5-dimethanol, or oxazole-2,5-dimethanol. 3. Compounds according to claim 1, wherein R is a drug radical wherein the drug is selected from the following: anti-inflammatory drugs: sulindac, analgesic drugs: acetaminophen, acetylsalicylsalicylic acid, benoxaprofen, buprenorphine, butorphanol, capsaicin, diacereine, dihydrocodeine, ethylmorphine, eugenol, phenylbutazone, meptazinol, morphine, nalbuphine, pentazocine, thiorphan, tramadol, actarit; bronchodilators and drugs active on the cholinergic system: albu terol, carbuterol, clenbuterol, diphylline, etophylline, fenoterol, ipratropium bromide, metaproterenol, oxybutynin pirbuterol, salmeterol, terbutaline, tiotropium bromide, zaprinast, cyclodrine, NS-21, 2-hydroxy-2,2-diphenyl-N-(1,2,3,6-tetrahydro-pyridin-4-ylmethyl)acetamide- ; expectorant/mucolytic drugs: acetyl-cysteine, ambroxol, bromexine, carbocysteine, guaiacol, ferulic acid, mecysteine hydrochloride, sobrerol; antiasthmatic/antiallergic antihistaminic drugs: cetirizine, chromoglycate, histamine, levocabastine, lodoxamide, montelukast, terfenadine, bromhexine; antithrombotic and vasoactive drugs: acetorphan, argatroban, clopidogrel, dalteparin, dipyridamole, enoxaparin, heparin, iloprost, midodrine, ozagrel, phenylpropanol amine, trifusal; antidiabetic drugs: tolrestat, nicotinamide; antitumoral drugs: anthramycin, daunorubicin, doxorubicin, epirubicin, fluorouracil, methotrexate, vinblastine; antiulcer drugs: cimetidine, omeprazole, pantoprazole; antihyperlipidemic drugs: lovastatin, pravastatin sodium, simvastatin; antibiotic drugs: amoxicillin, ampicillin, aztreonam, biapenem, carbenecillin, cefaclor, cefadroxil, cefamandole, cefatrizine, cefoxitin, clavulanic acid, dicloxacillin, imipenem, meclocycline, methacycline, moxalactam, panipenem, sulbactam, azithromycin, erythromycin, josamycin, miokamycin, rifabutine, rifamide, rifamycin, gentamicin, paromomycin, sisomicin, bacampicillin, carbomycin, clindamycin, ciprofloxacin, clinafloxacin, difloxacin, enrofloxacin, lomefloxacin, nadifloxacin, norfloxacin, ofloxacin, pipemidic acid, apicycline, clomocycline, oxytetracycline, nifurpirinol, nifurprazine, isoniazid, rifampin, rifapentine, dapsone, thiazolsulfone, sulfamethoxazole, sulfamoxole, metronidazole, arginine; antiviral drugs: acyclovir, famciclovir, ganciclovir, penciclovir, ribavi rin, vidarabine, zidovudine; bone resorption inhibitors: alendronic acid, etidronic acid, pamidronic acid; antidementia drugs: oxiracetam, tacrine, velnacrine. 4. Pharmaceutical formulations containing as active principle the compounds or their salts according to claim 1. 5. 4-nitroxybutyric acid 4'-acetylamino phenylester. 6. (Z)-5-fluoro-2-methyl-1-[[4-(methylsulphinyl)phenyl]methylene]-1H-inde- ne-3-acetic acid (4-nitroxy)butyl ester. 7. Compounds according to claim 1, wherein s=2. 8. Compounds according to claim 1, wherein X.sub.2 is a radical wherein two alkylene chains C.sub.1 C.sub.2 are linked to nonadjacent positions of the central ring. 9. Compounds according to claim 1, wherein the central ring has 5 or 6 atoms. 10. Compounds according to claim 1, wherein the precursor compounds of B are N-methyldiethanolamine, diethylenglycol, or thiodiethylenglycol. 11. Compounds or their salts having the following general formula (I): A--B--N(O).sub.S (I) wherein: s is an integer equal to 1 or 2; A=R--T.sub.1--, wherein R is a drug radical wherein the drug is selected from the following: anti-inflammatory drugs: aceclofenac, acemetacin, acetylsalicylic acid, 5-aminoacetylsalicylic acid, alclofenac, alminoprofen, amfenac, bendazac, bermoprofen, .gamma.-bisabolol, bromfenac, bromosaligenin, bucloxic acid, butibufen, carprofen, cinmetacin, clidanac, clopirac, sodium diclofenac, diflunisal, ditazol, enfenamic acid, etodolac, etofenamate, felbinac, fenbufen, fenclozic acid, fendosal, fenoprofen, fentiazac, fepradinol, flufenamic acid, flunixin, flunoxaprofen, flurbiprofen, glucametacin, glycol salicylate, ibuprofen, ibuproxam, indomethacin, indoprofen, isofezolac, isoxepac, isoxicam, ketoprofen, ketorolac, lornoxicam, loxoprofen, meclofenamic acid, mefenamic acid, meloxicam, mesalamine, metiazinic acid, mefezolac, naproxen, niflumic acid, olsalazine, oxaceprol, oxaprozin, oxyphenbutazone, parsalmide, perisoxal, phenyl acetylsalicylate, pyrazolac, piroxicam, pirprofen, pranoprofen, protizinic acid, salacetamide, salicilamide O-acetic acid, salicylsulphuric acid, salsalate, suprofen, suxibuzone, tenoxicam, tiaprofenic acid, tiaramide, tinoridine, tolfenamic acid, tolmetin, tropesin, xenbucin, ximoprofen, zaltoprofen, zomepirac, tomoxiprol; ACE-inhibitors: alacepril, benazepril, captopril, ceronapril, cilazapril, delapril, enalapril, enalaprilat, fosinopril, imidapril, lisinopril, losartan, moveltipril, naphthopidil, perindopril, quinapril, ramipril, spirapril, temocapril, trandolapril, urapidil; beta-blockers: acebutolol, alprenolol, amosulalol, arotinolol, atenolol, betaxolol, bevantolol, bucumolol, bufetolol, bufuralol, bunitrolol, bupranolol, butofilol, carazolol, carteolol, carvedilol, celiprolol, cetamolol, dilevalol, epanolol, esmolol, indenolol, labetalol, mepindolol, metipranolol, metoprolol, moprolol, nadolol, nadoxolol, nebivolol, nifenalol, nipridalol, oxprenolol, penbutolol, pindolol, practolol, pronethalol, propranolol, sotalol, sulfinalol, talinolol, tertatolol, tilisolol, timolol, toliprolol, xibenolol; and T.sub.1=(CO).sub.t or (X).sub.t', wherein X.dbd.O, S, NR.sub.1C, R.sub.1C is H or a linear or branched alkyl, having from 1 to 6 carbon atoms, or a free valence, t and t' are integers and equal to zero or 1, with the proviso that t=1 when t'=0; t=0 when t'=1; B=--T.sub.B--X.sub.2--O-- wherein T.sub.B=(CO) when t=0, T.sub.B=X when t'=0, X being as above defined; X.sub.2 is equal to R.sub.1B--X--R.sub.2B radical wherein R.sub.1B and R.sub.2B, equal to or different from each other, are linear or branched C.sub.1 C.sub.6 alkylenes, or X.sub.2 is a radical wherein two alkylene chains C.sub.1 C.sub.4 are linked to nonadjacent positions of a central ring having 4 or 6 atoms, said ring being an unsaturated cycloaliphatic ring, or a saturated or aromatic heterocylic ring, containing one or two heteroatoms, equal or different, selected from O, S, N; wherein the unsaturated cycloaliphatic ring does not have aromatic character according to Huckel's rule; and X is S or NR.sub.1C wherein NR.sub.1C is as above defined. 12. Compounds according to claim 11, wherein the precursor compounds of B are: N-methyldiethanolamine: HO--(CH.sub.2).sub.2--N(CH.sub.3)--(CH.sub.2).sub.2--OH, thiodiethylenglycol: HO--(CH.sub.2).sub.2--S--(CH.sub.2).sub.2--OH, 1,4 dioxane-2,6-dimethanol, tetrahydropyrane-2,6-dimethanol, 4H pyrane-2,6-dimethanol, tetrahydrothiopyrane-2,6-dimethanol, 1,4-dithiane-2,6-dimethanol, cyclohexene-1,5-dimethanol, thiazole-2,5-dimethanol, thiophene-2,5-dimethanol, or oxazole-2,5-dimethanol. 13. Compounds according to claim 12, wherein the precursor compounds of B are N-methyldiethanolamine, diethylenglycol, or thiodiethylenglycol. 14. Compounds according to claim 11, wherein R is a drug radical wherein the drug is selected from the following: ACE-inhibitors: captopril, enalapril, lisinopril, losartan, ramipril; beta blockers: alprenolol, atenolol, bupranolol, labetalol, metipranolol, metoprolol, pindolol, propranolol, timolol. 15. Compounds according to claim 11, wherein s=2. 16. Compounds according to claim 11, wherein X.sub.2 is a radical wherein two alkylene chains C.sub.1 C.sub.2 are linked to nonadjacent positions of the central ring. 17. Compounds according to claim 11, wherein the central ring has 5 or 6 atoms. 18. Pharmaceutical formulations containing as active principle the compounds or their salts according to claim 11. |
Details for Patent 7,186,753
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Jubilant Hollisterstier Llc | N/A | positive skin test control-histamine | Injection | 103891 | 03/13/1924 | ⤷ Try a Trial | 2019-08-12 |
Hoffmann-la Roche Inc. | PEGASYS COPEGUS COMBINATION PACK | peginterferon alfa-2a and ribavirin | 125083 | 06/04/2004 | ⤷ Try a Trial | 2019-08-12 | |
Schering Corporation A Subsidiary Of Merck & Co., Inc. | PEGINTRON/ REBETOL COMBO PACK | peginterferon alfa-2b and ribavirin | 125196 | 06/13/2008 | ⤷ Try a Trial | 2019-08-12 | |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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