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Last Updated: April 26, 2024

Claims for Patent: 7,186,509

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Summary for Patent: 7,186,509

Title:	Detection of a genetic predisposition to cancers in cats
Abstract:	Methods are provided for the detection of susceptibility to cancer and non-cancerous pathologies in a mammal. Diagnostic kits are also provided.
Inventor(s):	Kanjilal; Sagarika (Shoreview, MN)
Assignee:	Andx, Inc. (St. Paul, MN)
Application Number:	10/341,550
Patent Claims:	1. A method of detecting a susceptibility to a cancer in a cat comprising: obtaining a biological sample chosen from either a normal tissue and a bodily fluid from the cat, wherein the biological sample from the cat includes at least one cell containing a germline DNA sequence for a p53 allele; and detecting a molecular biomarker in the biological sample obtained from the cat, wherein the molecular biomarker is a p53 allele comprising an insertion of a thymidine nucleotide at position 246, 247, or 248 of SEQ ID NO: 14 as compared to position 246, 247, or 248 of SEQ ID NO: 16, wherein the presence of the molecular biomarker is indicative of the cancer susceptibility in the cat. 2. The method of claim 1, wherein the detecting comprises contacting the sample with at least one nucleic acid segment, wherein the segment comprises SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13. 3. The method of claim 1, wherein the cancer is sarcoma or a vaccine-associated feline sarcoma. 4. The method of claim 1, wherein the insertion of the thymidine nucleotide at position 246, 247 or 248 in SEQ ID NO: 14 as compared to position 246 247 as in SEQ ID NO: 16 is in an intron 7 of at least one of the alleles of a p53 gene nucleotide sequence. 5. A method of detecting a susceptibility to a vaccine-associated feline sarcoma (VAFS) in a cat comprising: obtaining a biological sample chosen from either a normal tissue and a bodily fluid from the cat, wherein the biological sample from the cat includes at least one cell containing a germline DNA sequence for a p53 allele; and detecting a molecular biomarker in the biological sample obtained from the cat, wherein the molecular biomarker is a p53 allele comprising an insertion of a thymidine nucleotide at position 246, 247, or 248 of SEQ ID NO: 14 as compared to position 246, 247, or 248 of SEQ ID NO: 16, wherein the presence of the molecular biomarker is indicative of the VAFS susceptibility in the cat. 6. The method of claim 5, wherein the detecting comprises contacting the sample with at least one nucleic acid segment, wherein the segment comprises SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13. 7. The method of claim 5, wherein the insertion of the thymidine nucleotide at position 246, 247 or 248 in SEQ ID NO: 14 as compared to position 246 247 as in SEQ ID NO: 16 is in an intron 7 of at least one of the alleles of a p53 gene nucleotide sequence.

Details for Patent 7,186,509

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2022-01-11
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2022-01-11
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2022-01-11
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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