Claims for Patent: 7,071,216

Summary for Patent: 7,071,216

Title:	Substituted benz-azoles and methods of their use as inhibitors of Raf kinase
Abstract:	New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
Inventor(s):	Renhowe; Paul A. (Danville, CA), Ramurthy; Savithri (Walnut Creek, CA), Amiri; Payman (Walnut Creek, CA), Levine; Barry Haskell (Lafayette, CA), Poon; Daniel J. (Oakland, CA), Subramanian; Sharadha (San Ramon, CA), Sung; Leonard (Irvine, CA), Fantl; Wendy (San Francisco, CA), Hansen; Teresa (Danville, CA), McBride; Christopher (Oakland, CA), Shafer; Cynthia M. (El Sobrante, CA)
Assignee:	Chiron Corporation (Emeryville, CA)
Application Number:	10/405,945
Patent Claims:	1. A compound of the formula (I): ##STR01156## wherein, X.sub.1 and X.sub.2 are .dbd.N-- or --NR.sub.4--, provided that if X.sub.1 is --NR.sub.4--, then X.sub.2 is .dbd.N--, or if X.sub.2 is --NR.sub.4--, then X.sub.1 is .dbd.N--; Y is O or S; A.sub.1 is substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, aryl, polycyclic aryl, polycyclic arylalkyl, heteroaryl, biaryl, heteroarylaryl, heteroarylheteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, biarylalkyl, or heteroarylarylalkyl; A.sub.2 is substituted or unsubstituted heteroaryl; R.sub.1 is O or H, and R.sub.2 is NR.sub.5 R.sub.6 or hydroxyl; or R.sub.1 is taken together with R.sub.2 to form a substituted or unsubstituted heterocycloalkyl or heteroaryl group; wherein, the dashed line represents a single or double bond, provided that ##STR01157## represents a double bond when R.sub.1 is O and ##STR01158## represents a single bond when R.sub.1 is H; R.sub.3 is hydrogen, halogen, loweralkyl, or loweralkoxy; R.sub.4 is hydrogen, hydroxyl, alkylamino, dialkylamino or alkyl; R.sub.5 and R.sub.6 are independently selected from hydrogen, and substituted or unsubstituted alkyl, alkoxyalkyl, aminoalkyl, amidoalkyl, acyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyloxyalkylheterocyclo, and heteroarylalkyl; or R.sub.5 and R.sub.6 are taken together to form substituted or unsubstituted heterocyclo or heteroaryl; and the pharmaceutically acceptable salts, esters and prodrugs thereof. 2. A compound of claim 1 wherein X.sub.1 is NR.sub.4. 3. A compound of claim 2 wherein R.sub.4 is hydrogen. 4. A compound of claim 2 wherein R.sub.4 is methyl. 5. A compound of claim 1 wherein Y is O. 6. A compound of claim 1 wherein A.sub.1 is selected from the group consisting of substituted or unsubstituted phenyl, pyridyl, pyrimidinyl, phenylalkyl, pyridylalkyl, pyrimidinylalkyl, heterocyclylcarbonylphenyl, heterocyclylphenyl, heterocyclylalkylphenyl, chlorophenyl, fluorophenyl, bromophenyl, iodophenyl, dihalophenyl, nitrophenyl, 4-bromophenyl, 4-chlorophenyl, alkylbenzoate, alkoxyphenyl, dialkoxyphenyl, dialkylphenyl, trialkylphenyl, thiophene, thiophene-2-carboxylate, alkylthiophenyl, trifluoromethylphenyl, acetylphenyl, sulfamoylphenyl, biphenyl, cyclohexylphenyl, phenyloxyphenyl, dialkylaminophenyl, alkylbromophenyl, alkylchlorophenyl, alkylflourophenyl, triflouromethylchlorophenyl, triflouromethylbromophenyl, indenyl, 2,3-dihydroindenyl, tetralinyl, trifluorophenyl, (trifluoromethyl)thiophenyl, alkoxybiphenyl, morpholinyl, N-piperazinyl, N-morpholinylalkyl, piperazinylalkyl, cyclohexylalkyl, indolyl, 2,3-dihydroindolyl, 1-aceytl-2,3-dihydroindolyl, cycloheptyl, bicyclo[2.2.1]hept-2-yl, hydroxyphenyl, hydroxyalkylphenyl, pyrrolidinyl, pyrrolidin-1-yl, pyrrolidin-1-ylalkyl, 4-amino(imino)methylphenyl, isoxazolyl, indazolyl, adamantyl, bicyclohexyl, quinuclidinyl, imidazolyl, benzimidazolyl, imidazolylphenyl, phenylimidazolyl, pthalamido, napthyl, benzophenone, anilinyl, anisolyl, quinolinyl, quinolinonyl, phenylsulfonyl, phenylalkylsulfonyl, 9H-flouren-1-yl, piperidin-1-yl, piperidin-1-ylalkyl, cyclopropyl, cyclopropylalkyl, pyrimidin-5-ylphenyl, quinolidinylphenyl, furanyl, furanylphenyl, N-methylpiperidin-4-yl, pyrrolidin-4-ylpyridinyl, 4-diazepan-1-yl, hydroxypyrrolidn-1-yl, dialkylaminopyrrolidin-1-yl, 1,4'-bipiperidin-1'-yl, and (1,4'-bipiperidin-1'-ylcarbonyl)phenyl. 7. A compound of claim 1 wherein A.sub.2 is substituted or unsubstituted pyridyl. 8. A compound of claim 1 wherein R.sub.1 is O and ##STR01159## represents a double bond. 9. A compound of claim 1 wherein R.sub.2 is NR.sub.5R.sub.6, R.sub.5 is hydrogen and R.sub.6 is selected from hydrogen, and substituted or unsubstituted alkyl, alkoxyalkyl, aminoalkyl, amidoalkyl, acyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyloxyalkylheterocyclo, and heteroarylalkyl. 10. A compound of claim 1 wherein R.sub.1 is taken together with R.sub.2 to form a substituted or unsubstituted heterocycloalkyl or heteroaryl group. 11. A compound of claim 1 wherein R.sub.3 is loweralkoxy. 12. A compound of claim 11 wherein R.sub.3 is methoxy. 13. A compound of claim 1 wherein R.sub.4 is loweralkyl. 14. A compound of claim 13 wherein R.sub.4 is methyl. 15. The compound of claim 1 wherein R.sub.1 is O, R.sub.2 is NR.sub.5R.sub.6, R.sub.5 is H, and R.sub.6 is methyl. 16. A compound of the formula (II): ##STR01160## wherein and Y is O or S; A.sub.1 is substituted or unsubstituted cycloalkyl, heterocycloalkyl, aryl, polycyclic aryl, polycyclic arylalkyl, heteroaryl, biaryl, heteroarylaryl, heteroarylheteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, biarylalkyl, or heteroarylarylalkyl; A.sub.2 is substituted or unsubstituted heteroaryl; R.sub.1 is O and R.sub.2 is NR.sub.5 R.sub.6; or R.sub.1 is taken together with R.sub.2 to form a substituted or unsubstituted heterocycloalkyl or heteroaryl group; wherein, the dashed line represents a single or double bond, provided that R.sub.1 is O, ##STR01161## represents a double bond; R.sub.3 is hydrogen, halogen, loweralkyl, or loweralkoxy; R.sub.4 is hydrogen or loweralkyl; R.sub.5 and R.sub.6 are independently selected from hydrogen, and substituted or unsubstituted alkyl, alkoxyalkyl, aminoalkyl, amidoalkyl, acyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyloxyalkylheterocyclo, and heteroarylalkyl; or R5 and R6 are taken together to form substituted or unsubstituted heterocyclo or heteroaryl; and the pharmaceutically acceptable salts, esters, and prodrugs thereof. 17. A compound of claim 16 wherein R4 is hydrogen. 18. A compound of claim 16 wherein R4 is methyl. 19. A compound of claim 16 wherein Y is O. 20. A compound of claim 16 wherein A1 is selected from the group consisting of substituted or unsubstituted phenyl, pyridyl, pyrimidinyl, phenylalkyl, pyridylalkyl, pyrimidinylalkyl, heterocyclylcarbonylphenyl, heterocyclylphenyl, heterocyclylalkylphenyl, chlorophenyl, fluorophenyl, bromophenyl, iodophenyl, dihalophenyl, nitrophenyl, 4-bromophenyl, 4-chlorophenyl, alkylbenzoate, alkoxyphenyl, dialkoxyphenyl, dialkylphenyl, trialkylphenyl, thiophene, thiophene-2-carboxylate, alkylthiophenyl, trifluoromethylphenyl, acetylphenyl, sulfamoylphenyl, biphenyl, cyclohexylphenyl, phenyloxyphenyl, dialkylaminophenyl, alkylbromophenyl, alkylchlorophenyl, alkylflourophenyl, triflouromethylchlorophenyl, triflouromethylbromophenyl indenyl, 2,3-dihydroindenyl, tetralinyl, trifluorophenyl, (trifluoromethyl)thiophenyl, alkoxybiphenyl, morpholinyl, N-piperazinyl, N-morpholinylalkyl, piperazinylalkyl, cyclohexylalkyl, indolyl, 2,3-dihydroindolyl, 1-aceytl-2,3-dihydroindolyl, cycloheptyl, bicyclo[2.2.1-]hept-2-yl, hydroxyphenyl, hydroxyalkylphenyl, pyrrolidinyl, pyrrolidin-1-yl, pyrrolidin-1-ylalkyl, 4-amino(imino)methylphenyl, isoxazolyl, indazolyl, adamantyl, bicyclohexyl, quinuclidinyl, imidazolyl, benzimidazolyl, imidazolylphenyl, phenylimidazolyl, pthalamido, napthyl, benzophenone, anilinyl, anisolyl, quinolinyl, quinolinonyl, phenylsulfonyl, phenylalkylsulfonyl, 9H-flouren-1-yl, piperidin-1-yl, piperidin-1-ylalkyl, cyclopropyl, cyclopropylalkyl, pyrimidin-5-ylphenyl, quinolidinylphenyl, furanyl, furanylphenyl, N-methylpiperidin-4-yl, pyrrolidin-4-ylpyridinyl, 4-diazepan-1-yl, hydroxypyrrolidn-1-yl, dialkylaminopyrrolidin-1-yl, 1,4'-bipiperidin-1'-yl, and (1,4'-bipiperidin-1'-ylcarbonyl)phenyl. 21. A compound of claim 16 wherein A.sub.2 is substituted or unsubstituted pyridyl. 22. A compound of claim 16 wherein R.sub.2 is NR.sub.5R.sub.6, R.sub.5 is hydrogen and R.sub.6 is selected from hydrogen, and substituted or unsubstituted alkyl, alkoxyalkyl, aminoalkyl, amidoalkyl, acyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyloxyalkylheterocyclo, and heteroarylalkyl. 23. A compound of claim 16 wherein R.sub.1 is taken together with R.sub.2 to form a substituted or unsubstituted heterocycloalkyl or heteroaryl group. 24. A compound of claim 16 wherein R.sub.1 is O, R.sub.2 is NR.sub.5R.sub.6, R.sub.5 is H, and R.sub.6 is methyl. 25. A compound of claim 16 wherein R.sub.3 is loweralkoxy. 26. A compound of claim 25 wherein R.sub.3 is methoxy. 27. A compound of claim 16 wherein R.sub.4 is loweralkyl. 28. A compound of claim 27 wherein R.sub.4 is methyl. 29. A compound of the formula (III): ##STR01162## wherein X is NR.sub.4; A.sub.1 is substituted or unsubstituted cycloalkyl, heterocycloalkyl, aryl, polycyclic aryl, polycyclic arylalkyl, heteroaryl, biaryl, heteroarylaryl, heteroarylheteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, biarylalkyl, or heteroarylarylalkyl; A.sub.2 is substituted or unsubstituted heteroaryl; R.sub.1 is O and R.sub.2 is NR.sub.5 R.sub.6; or R.sub.1 is taken together with R.sub.2 to form a substituted or unsubstituted heterocycloalkyl or heteroaryl group; wherein, the dashed line represents a single or double bond, provided that when R.sub.1 is O, ##STR01163## represents a double bond; R.sub.3 is hydrogen, halogen, loweralkyl, or loweralkoxy; R.sub.4 is hydrogen or loweralkyl; R.sub.5 and R.sub.6 are independently selected from hydrogen, and substituted or unsubstituted alkyl, alkoxyalkyl, aminoalkyl, amidoalkyl, acyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyloxyalkylheterocyclo, and heteroarylalkyl; or R5 and R6 are taken together to form substituted or unsubstituted heterocyclo or heteroaryl; and the pharmaceutically acceptable salts, esters and prodrugs thereof. 30. A compound of claim 29 wherein R.sub.4 is hydrogen. 31. A compound of claim 29 wherein R.sub.4 is methyl. 32. A compound of claim 29 wherein A.sub.1 is selected from the group consisting of substituted or unsubstituted phenyl, pyridyl, pyrimidinyl, phenylalkyl, pyridylalkyl, pyrimidinylalkyl, heterocyclylcarbonylphenyl, heterocyclylphenyl, heterocyclylalkylphenyl, chlorophenyl, fluorophenyl, bromophenyl, iodophenyl, dihalophenyl, nitrophenyl, 4-bromophenyl, 4-chlorophenyl, alkylbenzoate, alkoxyphenyl, dialkoxyphenyl, dialkylphenyl, trialkylphenyl, thiophene, thiophene-2-carboxylate, alkylthiophenyl, trifluoromethylphenyl, acetylphenyl, sulfamoylphenyl, biphenyl, cyclohexylphenyl, phenyloxyphenyl, dialkylaminophenyl, alkylbromophenyl, alkylchlorophenyl, alkylflourophenyl, triflouromethylchlorophenyl, triflouromethylbromophenyl indenyl, 2,3-dihydroindenyl, tetralinyl, trifluorophenyl, (trifluoromethyl)thiophenyl, alkoxybiphenyl, morpholinyl, N-piperazinyl, N-morpholinylalkyl, piperazinylalkyl, cyclohexylalkyl, indolyl, 2,3-dihydroindolyl, 1-aceytl-2,3-dihydroindolyl, cycloheptyl, bicyclo[2.2.1]hept-2-yl, hydroxyphenyl, hydroxyalkylphenyl, pyrrolidinyl, pyrrolidin-1-yl, pyrrolidin-1-ylalkyl, 4-amino(imino)methylphenyl, isoxazolyl, indazolyl, adamantyl, bicyclohexyl, quinuclidinyl, imidazolyl, benzimidazolyl, imidazolylphenyl, phenylimidazolyl, pthalamido, napthyl, benzophenone, anilinyl, anisolyl, quinolinyl, quinolinonyl, phenylsulfonyl, phenylalkylsulfonyl, 9H-flouren-1-yl, piperidin-1-yl, piperidin-1-ylalkyl, cyclopropyl, cyclopropylalkyl, pyrimidin-5-ylphenyl, quinolidinylphenyl, furanyl, furanylphenyl, N-methylpiperidin-4-yl, pyrrolidin-4-ylpyridinyl, 4-diazepan-1-yl, hydroxypyrrolidn-1-yl, dialkylaminopyrrolidin-1-yl, 1,4'-bipiperidin-1'-yl, and (1,4'-bipiperidin-1'-ylcarbonyl)phenyl. 33. A compound of claim 29 wherein A.sub.2 is substituted or unsubstituted pyridyl. 34. A compound of claim 29 wherein R.sub.2 is NR.sub.5R.sub.6, R.sub.5 is hydrogen and R.sub.6 is selected from hydrogen, and substituted or unsubstituted alkyl, alkoxyalkyl, aminoalkyl, amidoalkyl, acyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyloxyalkylheterocyclo, and heteroarylalkyl. 35. A compound of claim 29 wherein R.sub.1 is taken together with R.sub.2 to form a substituted or unsubstituted heterocycloalkyl or heteroaryl group. 36. A compound of claim 29 wherein R.sub.3 is loweralkoxy. 37. A compound of claim 36 wherein R.sub.3 is methoxy. 38. A compound of claim 29 wherein R.sub.4 is loweralkyl. 39. A compound of claim 38 wherein R.sub.4 is methyl. 40. A compound of claim 29 wherein R.sub.1 is O, R.sub.2 is NR.sub.5R.sub.6, R.sub.5 is H, and R.sub.6 is methyl. 41. A compound of the formula (IV): ##STR01164## wherein X is NR.sub.4; Y is O or S; A.sub.1 is substituted or unsubstituted cycloalkyl, heterocycloalkyl, aryl, polycyclic aryl, polycyclic arylalkyl, heteroaryl, biaryl, heteroarylaryl, heteroarylheteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, biarylalkyl, or heteroarylarylalkyl; R.sub.1 is O and R.sub.2 is NR.sub.5 R.sub.6; or R.sub.1 is taken together with R.sub.2 to form a substituted or unsubstituted heterocycloalkyl or heteroaryl group; wherein, the dashed line represents a single or double bond, provided that when R.sub.1 is O, ##STR01165## represents a double bond; R.sub.3 is hydrogen, halogen, loweralkyl, or loweralkoxy; R.sub.4 is hydrogen or loweralkyl; R.sub.5 and R.sub.6 are independently selected from hydrogen, and substituted or unsubstituted alkyl, alkoxyalkyl, aminoalkyl, amidoalkyl, acyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyloxyalkylheterocyclo, and heteroarylalkyl; or R5 and R6 are taken together to form substituted or unsubstituted heterocyclo or heteroaryl; and the pharmaceutically acceptable salts, esters and prodrugs thereof. 42. A compound of claim 41 wherein R.sub.4 is hydrogen. 43. A compound of claim 41 wherein R.sub.4 is methyl. 44. A compound of claim 41 wherein Y is O. 45. A compound of claim 41 wherein A.sub.1 is selected from the group consisting of substituted or unsubstituted phenyl, pyridyl, pyrimidinyl, phenylalkyl, pyridylalkyl, pyrimidinylalkyl, heterocyclylcarbonylphenyl, heterocyclylphenyl, heterocyclylalkylphenyl, chlorophenyl, fluorophenyl, bromophenyl, iodophenyl, dihalophenyl, nitrophenyl, 4-bromophenyl, 4-chlorophenyl, alkylbenzoate, alkoxyphenyl, dialkoxyphenyl, dialkylphenyl, trialkylphenyl, thiophene, thiophene-2-carboxylate, alkylthiophenyl, trifluoromethylphenyl, acetylphenyl, sulfamoylphenyl, biphenyl, cyclohexylphenyl, phenyloxyphenyl, dialkylaminophenyl, alkylbromophenyl, alkylchlorophenyl, alkylflourophenyl, triflouromethylchlorophenyl, triflouromethylbromophenyl indenyl, 2,3-dihydroindenyl, tetralinyl, trifluorophenyl, (trifluoromethyl)thiophenyl, alkoxybiphenyl, morpholinyl, N-piperazinyl, N-morpholinylalkyl, piperazinylalkyl, cyclohexylalkyl, indolyl, 2,3-dihydroindolyl, 1-aceytl-2,3-dihydroindolyl, cycloheptyl, bicyclo[2.2.1]hept-2-yl, hydroxyphenyl, hydroxyalkylphenyl, pyrrolidinyl, pyrrolidin-1-yl, pyrrolidin-1-ylalkyl, 4-amino(imino)methylphenyl, isoxazolyl, indazolyl, adamantyl, bicyclohexyl, quinuclidinyl, imidazolyl, benzimidazolyl, imidazolylphenyl, phenylimidazolyl, pthalamido, napthyl, benzophenone, anilinyl, anisolyl, quinolinyl, quinolinonyl, phenylsulfonyl, phenylalkylsulfonyl, 9H-flouren-1-yl, piperidin-1-yl, piperidin-1-ylalkyl, cyclopropyl, cyclopropylalkyl, pyrimidin-5-ylphenyl, quinolidinylphenyl, furanyl, furanylphenyl, N-methylpiperidin-4-yl, pyrrolidin-4-ylpyridinyl, 4-diazepan-1-yl, hydroxypyrrolidn-1-yl, dialkylaminopyrrolidin-1-yl, 1,4'-bipiperidin-1'-yl, and (1,4'-bipiperidin-1'-ylcarbonyl)phenyl. 46. A compound of claim 41 wherein R.sub.2 is NR.sub.5R.sub.6, R.sub.5 is hydrogen and R.sub.6 is selected from hydrogen, and substituted or unsubstituted alkyl, alkoxyalkyl, aminoalkyl, amidoalkyl, acyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyloxyalkylheterocyclo, and heteroarylalkyl. 47. A compound of claim 41 wherein R.sub.1 is taken together with R.sub.2 to form a substituted or unsubstituted heterocycloalkyl or heteroaryl group. 48. A compound of claim 41 wherein R.sub.3 is loweralkoxy. 49. A compound of claim 48 wherein R.sub.3 is methoxy. 50. A compound of claim 44 wherein R.sub.4 is loweralkyl. 51. A compound of claim 50 wherein R.sub.4 is methyl. 52. A compound of claim 41 wherein R.sub.1 is O, R.sub.2 is NR.sub.5R.sub.6, R.sub.5 is H, and R.sub.6 is methyl. 53. A compound of the formula (V): ##STR01166## wherein X is NR.sub.4; A.sub.1 is substituted or unsubstituted cycloalkyl, heterocycloalkyl, aryl, polycyclic aryl, polycyclic arylalkyl, heteroaryl, biaryl, heteroarylaryl, heteroarylheteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, biarylalkyl, or heteroarylarylalkyl; R.sub.1 is O and R.sub.2 is NR.sub.5 R.sub.6; or R.sub.1 is taken together with R.sub.2 to form a substituted or unsubstituted heterocycloalkyl or heteroaryl group; wherein, the dashed line represents a single or double bond, provided that when R.sub.1is O, ##STR01167## represents a double bond; R.sub.3 is hydrogen, halogen, loweralkyl, or loweralkoxy; R.sub.4 is hydrogen or loweralkyl; R.sub.5 and R.sub.6 are independently selected from hydrogen, and substituted or unsubstituted alkyl, alkoxyalkyl, aminoalkyl, amidoalkyl, acyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyloxyalkylheterocyclo, and heteroarylalkyl; or R5 and R6 are taken together to form substituted or unsubstituted heterocyclo or heteroaryl; and the pharmaceutically acceptable salts, esters and prodrugs thereof. 54. A compound of claim 53 wherein R.sub.4 is hydrogen. 55. A compound of claim 53 wherein R.sub.4 is methyl. 56. A compound of claim 53 wherein A.sub.1 is selected from the group consisting of substituted or unsubstituted phenyl, pyridyl, pyrimidinyl, phenylalkyl, pyridylalkyl, pyrimidinylalkyl, heterocyclylcarbonylphenyl, heterocyclylphenyl, heterocyclylalkylphenyl, chlorophenyl, fluorophenyl, bromophenyl, iodophenyl, dihalophenyl, nitrophenyl, 4-bromophenyl, 4-chlorophenyl, alkylbenzoate, alkoxyphenyl, dialkoxyphenyl, dialkylphenyl, trialkylphenyl, thiophene, thiophene-2-carboxylate, alkylthiophenyl, trifluoromethylphenyl, acetylphenyl, sulfamoylphenyl, biphenyl, cyclohexylphenyl, phenyloxyphenyl, dialkylaminophenyl, alkylbromophenyl, alkylchlorophenyl, alkylflourophenyl, triflouromethylchlorophenyl, triflouromethylbromophenyl indenyl, 2,3-dihydroindenyl, tetralinyl, trifluorophenyl, (trifluoromethyl)thiophenyl, alkoxybiphenyl, morpholinyl, N-piperazinyl, N-morpholinylalkyl, piperazinylalkyl, cyclohexylalkyl, indolyl, 2,3-dihydroindolyl, 1-aceytl-2,3-dihydroindolyl, cycloheptyl, bicyclo [2.2.1]hept-2-yl, hydroxyphenyl, hydroxyalkylphenyl, pyrrolidinyl, pyrrolidin-1-yl, pyrrolidin-1-ylalkyl, 4-amino(imino)methylphenyl, isoxazolyl, indazolyl, adamantyl, bicyclohexyl, quinuclidinyl, imidazolyl, benzimidazolyl, imidazolylphenyl, phenylimidazolyl, pthalamido, napthyl, benzophenone, anilinyl, anisolyl, quinolinyl, quinolinonyl, phenylsulfonyl, phenylalkylsulfonyl, 9H-flouren-1-yl, piperidin-1-yl, piperidin-1-ylalkyl, cyclopropyl, cyclopropylalkyl, pyrimidin-5-ylphenyl, quinolidinylphenyl, furanyl, furanylphenyl, N-methylpiperidin-4-yl, pyrrolidin-4-ylpyridinyl, 4-diazepan-1-yl, hydroxypyrrolidn-1-yl, dialkylaminopyrrolidin-1-yl, 1,4'-bipiperidin-1'-yl, and (1,4'-bipiperidin-1'-ylcarbonyl)phenyl. 57. A compound of claim 53 wherein R.sub.2 is NR.sub.5R.sub.6, R.sub.5 is hydrogen and R.sub.6 is selected from hydrogen, and substituted or unsubstituted alkyl, alkoxyalkyl, aminoalkyl, amidoalkyl, acyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, alkyloxyalkylheterocyclo, and heteroarylalkyl. 58. A compound of claim 53 wherein R.sub.1 is taken together with R.sub.2 to form a substituted or unsubstituted heterocycloalkyl or heteroaryl group. 59. A compound of claim 53 wherein R.sub.3 is loweralkoxy. 60. A compound of claim 59 wherein R.sub.3 is methoxy. 61. A compound of claim 53 wherein R.sub.4 is loweralkyl. 62. A compound of claim 61 wherein R.sub.4 is methyl. 63. A compound of claim 53 wherein R.sub.1 is O, R.sub.2 is NR.sub.5R.sub.6, R.sub.5 is H, and R.sub.6 is methyl. 64. A composition comprising an amount of a compound of claim 1, 16, 29, 41, or 53 effective to inhibit Raf activity in a human or animal subject when administered thereto, together with a pharmaceutically acceptable carrier. 65. A composition of claim 64 which further comprises at least one additional agent for the treatment of cancer. 66. A composition of claim 65 in which the at least one additional agent for the treatment of cancer is selected from irinotecan, topotecan, gemeitabine, 5-fluorouracil, leucovorin carboplatin, cisplatin, taxanes, tezacitabine, cyclophosphamide, vinca alkaloids, imatinib, anthracyclines, rituximab and trastuzumab.

Details for Patent 7,071,216

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Genentech, Inc.	RITUXAN	rituximab	Injection	103705	11/26/1997		2022-03-29
Idec Pharmaceuticals Corp.	RITUXAN	rituximab	Injection	103737	02/19/2002		2022-03-29
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	09/25/1998		2022-03-29
Genentech, Inc.	HERCEPTIN	trastuzumab	For Injection	103792	02/10/2017		2022-03-29
Genentech, Inc.	RITUXAN HYCELA	rituximab and hyaluronidase human	Injection	761064	06/22/2017		2022-03-29