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Last Updated: May 8, 2024

Claims for Patent: 6,903,194

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Summary for Patent: 6,903,194

Title:	Antibody against human parathormone related peptides
Abstract:	Disclosed are an antibody against human para-thyroid-hormone-related protein, a DNA coding for the antibody, a recombinant vector containing the DNA, a transformant transformed with the recombinant vector, a method for preparation of the antibody, and uses of the antibody.
Inventor(s):	Sato; Koh (Shizuoka, JP), Wakahara; Yuji (Shizuoka, JP), Yabuta; Naohiro (Shizuoka, JP)
Assignee:	Chungai Seiyaku Kabushiki Kaisha (Tokyo, JP)
Application Number:	09/269,332
Patent Claims:	1. An isolated polypeptide comprising an L chain V region of a humanized antibody comprising an amino acid sequence chosen from SEQ ID NOs: 48-51. 2. An isolated polypeptide comprising an L chain V region of a humanized antibody comprising an amino acid sequence chosen from SEQ ID NOs: 52-55. 3. An isolated polypeptide comprising an H chain V region of a humanized antibody comprising an amino acid sequence as shown in SEQ ID NO: 56. 4. An isolated L chain of a humanized antibody which binds to a human parathyroid hormone related protein, comprising a polypeptide comprising an L chain C region of a human antibody and a polypeptide comprising an L chain V region according to claim 1 or 2. 5. An isolated H chain of a humanized antibody which binds to a human parathyroid hormone related protein, comprising a polypeptide comprising an H chain C region of a human antibody and a polypeptide comprising an H chain V region according to claim 3. 6. An isolated humanized antibody comprising an L chain of a humanized antibody according to claim 4 and an H chain of a humanized antibody according to claim 5, wherein the humanized antibody binds to a human parathyroid hormone related protein. 7. An agent for suppressing hypercalcemia comprising the humanized antibody of claim 6 as an effective ingredient. 8. An agent for suppressing hypercalcemia associated with malignant tumor, comprising the humanized antibody of claim 6 as an effective ingredient. 9. The agent for suppressing hypercalcemia according to claim 8, wherein the malignant tumor is at least one chosen from cancer of the pancreas, lung cancer, cancer of the pharynx, cancer of the larynx, cancer of the tongue, cancer of the gingiva, cancer of the esophagus, cancer of the stomach, cancer of the biliary duct, cancer of the breast, cancer of the kidney, cancer of the urinary bladder, cancer of the uterus and prostate cancer, and malignant lymphoma. 10. An agent for improving hypophosphatemia comprising, as an active ingredient, a substance capable of inhibiting the binding between parathyroid hormone related protein (PTHrP) and a receptor thereof, wherein the substance is the humanized antibody of claim 6. 11. A method of inhibiting the binding between PTHrP and a receptor thereof, comprising: combining the humanized antibody of claim 6 with the PTHrP; allowing said humanized antibody to bind to PTHrP; and inhibiting the binding of PTHrP to a PTHrP receptor.

Details for Patent 6,903,194

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015	⤷ Try a Trial	2016-09-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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