Claims for Patent: 6,783,963

Summary for Patent: 6,783,963

Title:	Process for the preparation of metal sulfide nanoparticles
Abstract:	The process of the invention reports a new biological method, instead of chemical or physical methods, for preparing colloidal nano-sized metal sulphides using fungi.
Inventor(s):	Mukherjee; Priyabrata (Pune, IN), Mandal; Deendayal (Pune, IN), Ahmad; Absar (Pune, IN), Sastry; Murali (Pune, IN), Kumar; Rajiv (Pune, IN)
Assignee:	Council of Scientific & Industrial Research (New Delhi, IN)
Application Number:	10/108,927
Patent Claims:	1. A process for the preparation of metal sulphide nano size particles, which comprises contacting wet fungus with a metal sulphate aqueous solution at temperature ranging between 15 to 40.degree. C. for a period ranging between 2 to 120 hrs to obtain a composition containing metal sulphide nano size particles, and separating the fungus from the metal sulphide nano size particles to thereby obtain the metal sulphide nano size particles. 2. A process as claimed in claim 1, wherein the metal sulphate is selected from the group consisting of cadium sulphate, lead sulphate, zinc sulphate, nickel sulphate, molybdenum sulphate and silver sulphate. 3. A process as claimed in claim 1, wherein the wet fungus is obtained by growing Fusarium oxysporum sp. in a culture medium for a period of 2 or more hours at temperature ranging between 15-40.degree. C. under aseptic conditions to produce a biomass, separating the biomass by centrifugation, washing the separated biomass several times with sterile water, and then incubating the biomass and metal sulphate mixture at 15 to 40.degree. C. and at atmospheric pressure. 4. A process for the preparation of metal sulphide nano size particles, which comprises contacting wet fungus with an aqueous solution containing a combination of cadmium ions and a source of sulphur at a temperature ranging between 15-40.degree. for a period ranging between 2 to 120 hours to obtain a composition containing metal sulphide nano size particles, and separating the fungus from the metal sulphide nano size particles to thereby obtain the metal sulphide nano size particles. 5. A process as claimed in claim 4, wherein the cadmium ions are provided by a water soluble cadmium salt selected from nitrates, halides and carbonates. 6. A process as claimed in claim 4, wherein the source of sulphur is selected from the group consisting of sulphates, sulphur and sulphides. 7. A process as claimed in claim 5, wherein the source of sulphur is selected from the group consisting of sodium sulphate, sodium sulphite, sodium sulphide and hydrogen sulphide. 8. A process as claimed in claim 1, wherein the metal sulphate solution is obtained by dissolving a metal sulphate in water. 9. A process as claimed in claim 1, wherein the concentration of the metal sulphate per gram of the wet fungus is in the range of 10 to 200 mg. 10. A process as claimed in claim 1, wherein the fungus is selected from a species of Fusarium, taken as whole cell as wet solid mass. 11. A process as claimed in claim 9, wherein the concentration of the metal sulphate is 10-100 mg metal sulphate per gram of the wet fungus. 12. A process as claimed in claim 9, wherein the concentration of the metal sulphate is 25-100 mg metal sulphate per gram of the wet fungus.

Details for Patent 6,783,963

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006		2039-09-23