Claims for Patent: 6,664,107
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Summary for Patent: 6,664,107
Title: | CD45 disrupted nucleic acid |
Abstract: | A mammal lacking expression of particular CD45 isoform in certain cells of the immune system is provided. The mammal may optionally contain a transgene encoding the CD45RO isoform. Also provided are methods of using these mammals. |
Inventor(s): | Mak; Tak Wah (Toronto, CA), Kishihara; Kenji (Fukuoka, JP) |
Assignee: | Ontario Cancer Institute, University Health Network (Toronto, CA) |
Application Number: | 08/191,225 |
Patent Claims: | 1. A DNA sequence comprising at least exons 6-8 of a mouse CD45 DNA construct into which a marker gene sequence has been substituted for at least exon 6 and intron 6.
2. The DNA sequence of claim 1 wherein the marker gene sequence is the neo gene. 3. A vector comprising the DNA construct of claim 1. 4. A mouse CD45 DNA construct comprising the fragment between the Sac I site in intron 5 and the BamHI site in intron 8, wherein a neo gene sequence has been substituted for at least exon 6 and intron 6. 5. A mouse embryonic stem cell comprising the DNA construct of claim 4. |
Details for Patent 6,664,107
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | 06/04/1986 | ⤷ Try a Trial | 2020-12-16 |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | ⤷ Try a Trial | 2020-12-16 | |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | Injection | 103132 | ⤷ Try a Trial | 2020-12-16 | |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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