You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: May 7, 2024

Claims for Patent: 6,660,715

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 6,660,715

Title:	Nonaqueous solutions and suspensions of macromolecules for pulmonary delivery
Abstract:	Methods and formulations for delivery of macromolecules, such as proteins, polysaccharides, and nucleic acids, are disclosed, where the macromolecule is dissolved or dispersed in a low toxicity organic solvent which can be aerosolized for delivery to a patient\'s lungs by inhalation. Optionally, appropriate solubility enhancers are also present in the formulations composition.
Inventor(s):	Klibanov; Alexander M. (Newton, MA)
Assignee:	Massachusetts Institute of Technology (Cambridge, MA)
Application Number:	09/443,716
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 6,660,715
Patent Claims:	1. A formulation for pulmonary delivery of a bioactive agent comprising a solution or suspension of a bioactive agent to be delivered in a biocompatible organic solvent suitable for aerosolization of the bioactive molecule, wherein the solvent is a class 3 residual solvent. 2. The formulation of claim 1 wherein the bioactive agent is a therapeutic, diagnostic or prophylactic agent. 3. The composition of claim 1 wherein the bioactive agent is a macromolecule selected from the group consisting of proteins, peptides, polysaccharides, oligosaccharides, and nucleic acid molecules. 4. The formulation of claim 2 wherein the biological agent is selected from the group consisting of vasoactive agents, neuroactive agents, hormones, anticoagulants, immunomodulating agents, cytotoxic agents, prophylactic agents, antibiotics, antivirals, antisense, antigens, and antibodies. 5. The formulation of claim 1 wherein the bioactive agent is for the treatment of a pulmonary disease or disorder. 6. The formulation of claim 1 wherein the bioactive agent is selected from the group consisting of insulin, calcitonin, human growth hormone, EPO, DNAse, gonadotropin-releasing hormone, granulocyte colony-stimulating factor, parathyroid hormone-related peptide, somatostatin, testosterone, progesterone, estradiol, nicotine, fentanyl, norethisterone, clonidine, scopolamine, salicylate, cromolyn sodium, salmeterol, formeterol, albuterol, and valium. 7. The formulation of claim 1 wherein the solvent is selected from the group consisting of ethanol, acetone, ethyl acetate, tetrahydofuran, ethyl ether, and propanol. 8. The formulation of claim 1 wherein the bioactive agent is present in solution or suspension at a concentration up to about 500 mg/ml. 9. The formulation of claim 8 wherein the bioactive agent is present as a suspension. 10. The formulation of claim 1 further comprising an agent selected from the group consisting of surfactants which enhance solubility of the bioactive agent, inorganic salts and viscosity modifying agents. 11. A method of delivery of a bioactive agent comprising administering to a patient an aerosol formulation of a solution or suspension of the bioactive agent in a biocompatible organic solvent, wherein the solvent is a class 3 residual.

Details for Patent 6,660,715

Subscribe to access the full database, or Try a Trial
Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015	⤷ Try a Trial	2018-11-19
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.