Claims for Patent: 6,645,974

Summary for Patent: 6,645,974

Title:	Androgen receptor modulators and methods for use thereof
Abstract:	Compounds of structural formula (I) as herein defined are disclosed as useful in a method for modulating the androgen receptor in a tissue selective manner in a patient in need of such modulation, as well as in a method of agonizing the androgen receptor in a patient, and in particular the method wherein the androgen receptor is antagonized in the prostate of a male patient or in the uterus of a female patient and agonized in bone and/or muscle tissue. These compounds are useful in the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including: osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, post-menopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, aplastic anemia and other hematopoietic disorders, pancreatic cancer, renal cancer, arthritis and joint repair, alone or in combination with other active agents. In addition, these compounds are useful as pharmaceutical composition ingredients alone and in combination with other active agents.
Inventor(s):	Hutchinson; John H. (La Jolla, CA), Breslin; Michael J. (Drexel Hill, PA), Rodan; Gideon A. (Bryn Mawr, PA), Sahoo; Soumya P. (Old Bridge, NJ), Duggan; Mark E. (Schwenksville, PA), Harada; Shun-Ichi (Ambler, PA), Schmidt; Azriel (Bryn Mawr, PA), Halczenko; Wasyl (Lansdale, PA), Towler; Dwight A. (Brentwood, MO)
Assignee:	Merck & Co., Inc. (Rahway, NJ)
Application Number:	10/205,634
Patent Claims:	1. A method for modulating the androgen receptor in a tissue selective manner in a patient in need of such modulation, comprising administering a therapeutically effective amount of a compound of structural formula I: ##STR9## wherein: "a" and "b" are independently selected from a single bond and a double bond; R.sup.1 is selected from: (1) C.sub.1-3 alkyl, (2) C.sub.2-3 alkenyl, (3) C.sub.3-6 cycloalkyl, (4) C.sub.1-3 alkyl wherein one or more of the hydrogen atoms has been replaced with a fluorine atom, (5) aryl, and (6) aryl-C.sub.1-3 alkyl; R.sup.2 is selected from: (1) aryl, either unsubstituted or substituted with one to three substituents selected from: (a) halogen, (b) aryl, (c) C.sub.1-8 alkyl, (d) C.sub.3-8 cycloalkyl, (e) C.sub.3-8 cycloheteroalkyl, (f) aryl C.sub.1-6 alkyl, (g) amino C.sub.0-6 alkyl, (h) C.sub.1-6 alkylamino C.sub.0-6 alkyl, (i) (C.sub.1-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (j) aryl C.sub.0-6 alkylamino C.sub.0-6 alkyl, (k) (aryl C.sub.0-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (l) C.sub.1-6 alkylthio, (m) aryl C.sub.0-6 alkylthio, (n) C.sub.1-6 alkylsulfinyl, (o) aryl C.sub.0-6 alkylsulfinyl, (p) C.sub.1-6 alkylsulfonyl, (q) aryl C.sub.0-6 alkylsulfonyl, (r) C.sub.1-6 alkoxy C.sub.0-6 alkyl, (s) aryl C.sub.0-6 alkoxy C.sub.0-6 alkyl, (t) hydroxycarbonyl C.sub.0-6 alkyl, (u) C.sub.1-6 alkoxycarbonyl C.sub.0-6 alkyl, (v) aryl C.sub.0-6 alkoxycarbonyl C.sub.0-6 alkyl, (w) hydroxycarbonyl C.sub.1-6 alkyloxy, (x) hydroxy C.sub.0-6 alkyl, (y) cyano, (z) nitro, (aa) perfluoroC.sub.1-4 alkyl, (bb) perfluoroC.sub.1-4 alkoxy, (cc) oxo, (dd) C.sub.1-6 alkylcarbonyloxy, (ee) aryl C.sub.0-6 alkylcarbonyloxy, (ff) alkyl C.sub.1-6 carbonylamino, (gg) aryl C.sub.0-6 alkylcarbonylamino, (hh) C.sub.1-6 alkylsulfonylamino, (ii) aryl C.sub.0-6 alkylsulfonylamino, (jj) C.sub.1-6 alkoxycarbonylamino, (kk) aryl C.sub.0-6 alkoxycarbonylamino, (ll) C.sub.1-6 alkylaminocarbonylamino, (mm) aryl C.sub.0-6 alkylaminocarbonylamino, (nn) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (oo) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (pp) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (qq) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, (rr) C.sub.0-6 alkylcarbonyl C.sub.0-6 alkyl, and (ss) aryl C.sub.0-6 alkylcarbonyl C.sub.0-6 alkyl; (2) C.sub.1-8 alkyl, unsubstituted or substituted with one to three substituents independently selected from: (a) halogen, (b) aryl, (c) C.sub.1-8 alkyl, (d) C.sub.3-8 cycloalkyl, (e) C.sub.3-8 cycloheteroalkyl, (f) amino, (g) C.sub.1-6 alkylamino, (h) (C.sub.1-6 alkyl).sub.2 amino, (i) aryl C.sub.0-6 alkylamino, (j) (aryl C.sub.0-6 alkyl).sub.2 amino, (k) C.sub.1-6 alkylthio, (l) aryl C.sub.0-6 alkylthio, (m) C.sub.1-6 alkylsulfinyl, (n) aryl C.sub.0-6 alkylsulfinyl, (o) C.sub.1-6 alkylsulfonyl, (p) aryl C.sub.0-6 alkylsulfonyl, (q) C.sub.1-6 alkoxy, (r) aryl C.sub.0-6 alkoxy, (s) hydroxycarbonyl, (t) C.sub.1-6 alkoxycarbonyl, (u) aryl C.sub.0-6 alkoxycarbonyl, (v) hydroxycarbonyl C.sub.1-6 alkyloxy, (w) hydroxy, (x) cyano, (y) nitro, (z) perfluoroC.sub.1-4 alkyl, (aa) perfluoroC.sub.1-4 alkoxy, (bb) oxo, (cc) C.sub.1-6 alkylcarbonyloxy, (dd) aryl C.sub.0-6 alkylcarbonyloxy, (ee) alkyl C.sub.1-6 carbonylamino, (if) aryl C.sub.0-6 alkylcarbonylamino, (gg) C.sub.1-6 alkylsulfonylamino, (hh) aryl C.sub.0-6 alkylsulfonylamino, (ii) C.sub.1-6 alkoxycarbonylamino, (jj) aryl C.sub.0-6 alkoxycarbonylamino, (kk) C.sub.1-6 alkylaminocarbonylamino, (ll) aryl C.sub.0-6 alkylaminocarbonylamino, (mm) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (nn) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (oo) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (pp) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, and (qq) spiro-C.sub.3-8 cycloalkyl; (3) perfluoroC.sub.1-8 alkyl, (4) C.sub.2-8 alkenyl, unsubstituted or substituted with one to three substituents independently selected from: (a) halogen, (b) aryl, (c) C.sub.1-8 alkyl, (d) C.sub.3-8 cycloalkyl, (e) C.sub.3-8 cycloheteroalkyl, (f) amino, (g) C.sub.1-6 alkylamino, (h) (C.sub.1-6 alkyl).sub.2 amino, (i) aryl C.sub.0-6 alkylamino, (j) (aryl C.sub.0-6 alkyl).sub.2 amino, (k) C.sub.1-6 alkylthio, (l) aryl C.sub.0-6 alkylthio, (in) C.sub.1-6 alkylsulfinyl, (n) aryl C.sub.0-6 alkylsulfinyl, (o) C.sub.1-6 alkylsulfonyl, (p) aryl C.sub.0-6 alkylsulfonyl, (q) C.sub.1-6 alkoxy, (r) aryl C.sub.0-6 alkoxy, (s) hydroxycarbonyl, (t) C.sub.1-6 alkoxycarbonyl, (u) aryl C.sub.0-6 alkoxycarbonyl, (v) hydroxycarbonyl C.sub.1-6 alkyloxy, (w) hydroxy, (x) cyano, (y) nitro, (z) perfluoroC.sub.1-4 alkyl, (aa) perfluoroC.sub.1-4 alkoxy, (bb) oxo, (cc) C.sub.1-6 alkylcarbonyloxy, (dd) aryl C.sub.0-6 alkylcarbonyloxy, (ee) alkyl C.sub.1-6 carbonylamino, (ff) aryl C.sub.0-6 alkylcarbonylamino, (gg) C.sub.1-6 alkylsulfonylamino, (hh) aryl C.sub.0-6 alkylsulfonylamino, (ii) C.sub.1-6 alkoxycarbonylamino, (jj) aryl C.sub.0-6 alkoxycarbonylamino, (kk) C.sub.1-6 alkylaminocarbonylamino, (ll) aryl C.sub.0-6 alkylaminocarbonylamino, (mm) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (nn) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (oo) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (pp) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, and (qq) spiro-C.sub.3-8 cycloalkyl; (5) C.sub.3-8 cycloalkyl, either unsubstituted or substituted with one to 3 substituents selected from: (a) halogen, (b) aryl, (c) C.sub.1-8 alkyl, (d) C.sub.3-8 cycloalkyl, (e) C.sub.3-8 cycloheteroalkyl, (f) aryl C.sub.1-6 alkyl, (g) amino C.sub.0-6 alkyl, (h) C.sub.1-6 alkylamino C.sub.0-6 alkyl, (i) (C.sub.1-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (j) aryl C.sub.0-6 alkylamino C.sub.0-6 alkyl, (k) (aryl C.sub.0-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (l) C.sub.1-6 alkylthio, (m) aryl C.sub.0-6 alkylthio, (n) C.sub.1-6 alkylsulfinyl, (o) aryl C.sub.0-6 alkylsulfinyl, (p) C.sub.1-6 alkylsulfonyl, (q) aryl C.sub.0-6 alkylsulfonyl, (r) C.sub.1-6 alkoxy C.sub.0-6 alkyl, (s) aryl C.sub.0-6 alkoxy C.sub.0-6 alkyl, (t) hydroxycarbonyl C.sub.0-6 alkyl, (u) C.sub.1-6 alkoxycarbonyl C.sub.0-6 alkyl, (v) aryl C.sub.0-6 alkoxycarbonyl C.sub.0-6 alkyl, (w) hydroxycarbonyl C.sub.1-6 alkyloxy, (x) hydroxy C.sub.0-6 alkyl, (y) cyano, (z) nitro, (aa) perfluoroC.sub.1-4 alkyl, (bb) perfluoroC.sub.1-4 alkoxy, (cc) oxo, (dd) C.sub.1-6 alkylcarbonyloxy, (ee) aryl C.sub.0-6 alkylcarbonyloxy, (ff) alkyl C.sub.1-6 carbonylamino, (gg) aryl C.sub.0-6 alkylcarbonylamino, (hh) C.sub.1-6 alkylsulfonylamino, (ii) aryl C.sub.0-6 alkylsulfonylamino, (jj) C.sub.1-6 alkoxycarbonylamino, (kk) aryl C.sub.0-6 alkoxycarbonylamino, (ll) C.sub.1-6 alkylaminocarbonylamino, (mm) aryl C.sub.0-6 alkylaminocarbonylamino, (nn) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (oo) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (pp) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (qq) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, (rr) C.sub.0-6 alkylcarbonyl C.sub.0-6 alkyl, and (ss) spiro-C.sub.3-8 cycloalkyl; (6) cycloheteroalkyl, unsubstituted or substituted with one to three substituents selected from: (a) halogen, (b) aryl, (c) C.sub.1-8 alkyl, (d) C.sub.3-8 cycloalkyl, (e) C.sub.3-8 cycloheteroalkyl, (f) aryl C.sub.1-6 alkyl, (g) amino C.sub.0-6 alkyl, (h) C.sub.1-6 alkylamino C.sub.0-6 alkyl, (i) (C.sub.1-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (j) aryl C.sub.0-6 alkylamino C.sub.0-6 alkyl, (k) (aryl C.sub.0-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (l) C.sub.1-6 alkylthio, (m) aryl C.sub.0-6 alkylthio, (n) C.sub.1-6 alkylsulfinyl, (o) aryl C.sub.0-6 alkylsulfinyl, (p) C.sub.1-6 alkylsulfonyl, (q) aryl C.sub.0-6 alkylsulfonyl, (r) C.sub.1-6 alkoxy C.sub.0-6 alkyl, (s) aryl C.sub.0-6 alkoxy C.sub.0-6 alkyl, (t) hydroxycarbonyl C.sub.0-6 alkyl, (u) C.sub.1-6 alkoxycarbonyl C.sub.0-6 alkyl, (v) aryl C.sub.0-6 alkoxycarbonyl C.sub.0-6 alkyl, (w) hydroxycarbonyl C.sub.1-6 alkyloxy, (x) hydroxy C.sub.0-6 alkyl, (y) cyano, (z) nitro, (aa) perfluoroC.sub.1-4 alkyl, (bb) perfluoroC.sub.1-4 alkoxy, (cc) oxo, (dd) C.sub.1-6 alkylcarbonyloxy, (ee) aryl C.sub.0-6 alkylcarbonyloxy, (ff) alkyl C.sub.1-6 carbonylamino, (gg) aryl C.sub.0-6 alkylcarbonylamino, (hh) C.sub.1-6 alkylsulfonylamino, (ii) aryl C.sub.0-6 alkylsulfonylamino, (jj) C.sub.1-6 alkoxycarbonylamino, (kk) aryl C.sub.0-6 alkoxycarbonylamino, (ll) C.sub.1-6 alkylaminocarbonylamino, (mm) aryl C.sub.0-6 alkylaminocarbonylamino, (nn) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (oo) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (pp) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (qq) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, and (rr) C.sub.0-6 alkylcarbonyl C.sub.0-6 alkyl, and (ss) spiro C.sub.3-8 cycloalkyl, provided that any heteroatom substituent is bonded to a carbon atom in the cycloheteroalkyl ring; R.sup.3 is selected from H and C.sub.1-8 alkyl, or R.sup.2 and R.sup.3, together with the nitrogen atom to which they are attached, form a 5- to 7-membered heterocyclic ring, optionally containing one or two additional heteroatoms selected from N, S, and O, optionally having one or more degrees of unsaturation, optionally fused to a 6-membered heteroaromatic or aromatic ring, either unsubstituted or substituted with one to three substituents selected from: (1) halogen, (2) aryl, (3) C.sub.1-8 alkyl, (4) C.sub.3-8 cycloalkyl, (5) C.sub.3-8 cycloheteroalkyl, (6) aryl C.sub.1-6 alkyl, (7) amino C.sub.0-6 alkyl, (8) C.sub.1-6 alkylamino C.sub.0-6 alkyl, (9) (C.sub.1-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (10) aryl C.sub.0-6 alkylamino C.sub.0-6 alkyl, (11) (aryl C.sub.0-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (12) C.sub.1-6 alkylthio, (13) aryl C.sub.0-6 alkylthio, (14) C.sub.1-6 alkylsulfinyl, (15) aryl C.sub.0-6 alkylsulfinyl, (16) C.sub.1-6 alkylsulfonyl, (17) aryl C.sub.0-6 alkylsulfonyl, (18) C.sub.1-6 alkoxy C.sub.0-6 alkyl, (19) aryl C.sub.0-6 alkoxy C.sub.0-6 alkyl, (20) hydroxycarbonyl C.sub.0-6 alkyl, (21) C.sub.1-6 alkoxycarbonyl C.sub.0-6 alkyl, (22) aryl C.sub.0-6 alkoxycarbonyl C.sub.0-6 alkyl, (23) hydroxycarbonyl C.sub.0-6 alkyloxy, (24) hydroxy C.sub.0-6 alkyl, (25) cyano, (26) nitro, (27) perfluoroC.sub.1-4 alkyl, (28) perfluoroC.sub.1-4 alkoxy, (29) oxo, (30) C.sub.1-6 alkylcarbonyloxy, (31) aryl C.sub.0-6 alkylcarbonyloxy, (32) C.sub.1-6 alkyl carbonylamino, (33) aryl C.sub.0-6 alkylcarbonylamino, (34) C.sub.1-6 alkylsulfonylamino, (35) aryl C.sub.0-6 alkylsulfonylamino, (36) C.sub.1-6 alkoxycarbonylamino, (37) aryl C.sub.0-6 alkoxycarbonylamino, (38) C.sub.1-6 alkylaminocarbonylamino, (39) aryl C.sub.0-6 alkylaminocarbonylamino, (40) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (41) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (42) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (43) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, and (44) spiro-C.sub.3-8 cycloalkyl provided that any heteroatom substituent is bonded to a carbon atom in the heterocyclic ring; R.sup.4 and R.sup.5 are each independently selected from (1) hydrogen, (2) halogen, (3) aryl, (4) C.sub.1-8 alkyl, (5) C.sub.3-8 cycloalkyl, (6) C.sub.3-8 cycloheteroalkyl, (7) aryl C.sub.1-6 alkyl, (8) amino C.sub.0-6 alkyl, (9) C.sub.1-6 alkylamino C.sub.0-6 alkyl, (10) (C.sub.1-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (11) aryl C.sub.0-6 alkylamino C.sub.0-6 alkyl, (12) (aryl C.sub.0-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (13) C.sub.1-6 alkylthio, (14) aryl C.sub.0-6 alkylthio, (15) C.sub.1-6 alkylsulfinyl, (16) aryl C.sub.0-6 alkylsulfinyl, (17) C.sub.1-6 alkylsulfonyl, (18) aryl C.sub.0-6 alkylsulfonyl, (19) C.sub.1-6 alkoxy C.sub.0-6 alkyl, (20) aryl C.sub.0-6 alkoxy C.sub.0-6 alkyl, (21) hydroxycarbonyl C.sub.0-6 alkyl, (22) C.sub.1-6 alkoxycarbonyl C.sub.0-6 alkyl, (23) aryl C.sub.0-6 alkoxycarbonyl C.sub.0-6 alkyl, (24) hydroxycarbonyl C.sub.1-6 alkyloxy, (25) hydroxy C.sub.0-6 alkyl, (26) cyano, (27) nitro, (28) perfluoroC.sub.1-4 alkyl, (29) perfluoroC.sub.1-4 alkoxy, (30) C.sub.0-6 alkylcarbonyl C.sub.0-6 alkyl, (31) C.sub.1-6 alkylcarbonyloxy, (32) aryl C.sub.0-6 alkylcarbonyloxy, (33) C.sub.1-6 alkyl carbonylamino, (34) aryl C.sub.0-6 alkylcarbonylamino, (35) C.sub.1-6 alkylsulfonylamino, (36) aryl C.sub.0-6 alkylsulfonylamino, (37) C.sub.1-6 alkoxycarbonylamino, (38) aryl C.sub.0-6 alkoxycarbonylamino, (39) C.sub.1-6 alkylaminocarbonylamino, (40) aryl C.sub.0-6 alkylaminocarbonylamino, (41) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (42) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (43) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, and (44) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy; or, R.sup.4 and R.sup.5 together form an oxo group or .dbd.CH.dbd.R.sup.6 or a spiro C.sub.3-7 cycloalkyl ring, unsubstituted or substituted with R.sup.6 ; R.sup.6 is selected from: (1) hydrogen, and (2) C.sub.1-4 alkyl; or a pharmaceutically acceptable salt thereof, and further wherein the tissue selective modulation of the androgen receptor is: 1) antagonizing in the prostate of a male patient or in the uterus of a female patient, and 2) agonizing in bone or muscle tissue. 2. A method of treating a condition which is caused by androgen deficiency or which can be ameliorated by androgen administration selected from: osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, post-menopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, aplastic anemia and other hematopoietic disorders, pancreatic cancer, renal cancer, arthritis and joint repair, in a patient in need of such treatment, comprising administering a therapeutically effective amount of a compound of structural formula I: ##STR10## wherein: "a" and "b" are independently selected from a single bond and a double bond; R.sup.1 is selected from: (1) C.sub.1-3 alkyl, (2) C.sub.2-3 alkenyl, (3) C.sub.3-6 cycloalkyl, (4) C.sub.1-3 alkyl wherein one or more of the hydrogen atoms has been replaced with a fluorine atom, (5) aryl, and (6) aryl-C.sub.1-3 alkyl; R.sup.2 is selected from: (1) aryl, either unsubstituted or substituted with one to three substituents selected from: (a) halogen, (b) aryl, (c) C.sub.1-8 alkyl, (d) C.sub.3-8 cycloalkyl, (e) C.sub.3-8 cycloheteroalkyl, (f) aryl C.sub.1-6 alkyl, (g) amino C.sub.0-6 alkyl, (h) C.sub.1-6 alkylamino C.sub.0-6 alkyl, (i) (C.sub.1-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (j) aryl C.sub.0-6 alkylamino C.sub.0-6 alkyl, (k) (aryl C.sub.0-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (l) C.sub.1-6 alkylthio, (m) aryl C.sub.0-6 alkylthio, (n) C.sub.1-6 alkylsulfinyl, (o) aryl C.sub.0-6 alkylsulfinyl, (p) C.sub.1-6 alkylsulfonyl, (q) aryl C.sub.0-6 alkylsulfonyl, (r) C.sub.1-6 alkoxy C.sub.0-6 alkyl, (s) aryl C.sub.0-6 alkoxy C.sub.0-6 alkyl, (t) hydroxycarbonyl C.sub.0-6 alkyl, (u) C.sub.1-6 alkoxycarbonyl C.sub.0-6 alkyl, (v) aryl C.sub.0-6 alkoxycarbonyl C.sub.0-6 alkyl, (w) hydroxycarbonyl C.sub.1-6 alkyloxy, (x) hydroxy C.sub.0-6 alkyl, (y) cyano, (z) nitro, (aa) perfluoroC.sub.1-4 alkyl, (bb) perfluoroC.sub.1-4 alkoxy, (cc) oxo, (dd) C.sub.1-6 alkylcarbonyloxy, (ee) aryl C.sub.0-6 alkylcarbonyloxy, (ff) alkyl C.sub.1-6 carbonylamino, (gg) aryl C.sub.0-6 alkylcarbonylamino, (hh) C.sub.1-6 alkylsulfonylamino, (ii) aryl C.sub.0-6 alkylsulfonylamino, (jj) C.sub.1-6 alkoxycarbonylamino, (kk) aryl C.sub.0-6 alkoxycarbonylamino, (ll) C.sub.1-6 alkylaminocarbonylamino, (mm) aryl C.sub.0-6 alkylaminocarbonylamino, (nn) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (oo) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (pp) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (qq) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, (rr) C.sub.0-6 alkylcarbonyl C.sub.0-6 alkyl, and (ss) aryl C.sub.0-6 alkylcarbonyl C.sub.0-6 alkyl; (2) C.sub.1-8 alkyl, unsubstituted or substituted with one to three substituents independently selected from: (a) halogen, (b) aryl, (c) C.sub.1-8 alkyl, (d) C.sub.3-8 cycloalkyl, (e) C.sub.3-8 cycloheteroalkyl, (f) amino, (g) C.sub.1-6 alkylamino, (h) (C.sub.1-6 alkyl).sub.2 amino, (i) aryl C.sub.0-6 alkylamino, (j) (aryl C.sub.0-6 alkyl).sub.2 amino, (k) C.sub.1-6 alkylthio, (l) aryl C.sub.0-6 alkylthio, (m) C.sub.1-6 alkylsulfinyl, (n) aryl C.sub.0-6 alkylsulfinyl, (o) C.sub.1-6 alkylsulfonyl, (p) aryl C.sub.0-6 alkylsulfonyl, (q) C.sub.1-6 alkoxy, (r) aryl C.sub.0-6 alkoxy, (s) hydroxycarbonyl, (t) C.sub.1-6 alkoxycarbonyl, (u) aryl C.sub.0-6 alkoxycarbonyl, (v) hydroxycarbonyl C.sub.1-6 alkyloxy, (w) hydroxy, (x) cyano, (y) nitro, (z) perfluoroC.sub.1-4 alkyl, (aa) perfluoroC.sub.1-4 alkoxy, (bb) oxo, (cc) C.sub.1-6 alkylcarbonyloxy, (dd) aryl C.sub.0-6 alkylcarbonyloxy, (ee) alkyl C.sub.1-6 carbonylamino, (ff) aryl C.sub.0-6 alkylcarbonylamino, (gg) C.sub.1-6 alkylsulfonylamino, (hh) aryl C.sub.0-6 alkylsulfonylamino, (ii) C.sub.1-6 alkoxycarbonylamino, (jj) aryl C.sub.0-6 alkoxycarbonylamino, (kk) C.sub.1-6 alkylaminocarbonylamino, (ll) aryl C.sub.0-6 alkylaminocarbonylamino, (mm) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (nn) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (oo) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (pp) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, and (qq) spiro-C.sub.3-8 cycloalkyl; (3) perfluoroC.sub.1-8 alkyl, (4) C.sub.2-8 alkenyl, unsubstituted or substituted with one to three substituents independently selected from: (a) halogen, (b) aryl, (c) C.sub.1-8 alkyl, (d) C.sub.3-8 cycloalkyl, (e) C.sub.3-8 cycloheteroalkyl, (f) amino, (g) C.sub.1-6 alkylamino, (h) (C.sub.1-6 alkyl).sub.2 amino, (i) aryl C.sub.0-6 alkylamino, (j) (aryl C.sub.0-6 alkyl).sub.2 amino, (k) C.sub.1-6 alkylthio, (l) aryl C.sub.0-6 alkylthio, (m) C.sub.1-6 alkylsulfinyl, (n) aryl C.sub.0-6 alkylsulfinyl, (o) C.sub.1-6 alkylsulfonyl, (p) aryl C.sub.0-6 alkylsulfonyl, (q) C.sub.1-6 alkoxy, (r) aryl C.sub.0-6 alkoxy, (s) hydroxycarbonyl, (t) C.sub.1-6 alkoxycarbonyl, (u) aryl C.sub.0-6 alkoxycarbonyl, (v) hydroxycarbonyl C.sub.1-6 alkyloxy, (w) hydroxy, (x) cyano, (y) nitro, (z) perfluoroC.sub.1-4 alkyl, (aa) perfluoroC.sub.1-4 alkoxy, (bb) oxo, (cc) C.sub.1-6 alkylcarbonyloxy, (dd) aryl C.sub.0-6 alkylcarbonyloxy, (ee) alkyl C.sub.1-6 carbonylamino, (ff) aryl C.sub.0-6 alkylcarbonylamino, (gg) C.sub.1-6 alkylsulfonylamino, (hh) aryl C.sub.0-6 alkylsulfonylamino, (ii) C.sub.1-6 alkoxycarbonylamino, (jj) aryl C.sub.0-6 alkoxycarbonylamino, (kk) C.sub.1-6 alkylaminocarbonylamino, (ll) aryl C.sub.0-6 alkylaminocarbonylamino, (mm) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (nn) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (oo) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (pp) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, and (qq) spiro-C.sub.3-8 cycloalkyl; (5) C.sub.3-8 cycloalkyl, either unsubstituted or substituted with one to 3 substituents selected from: (a) halogen, (b) aryl, (c) C.sub.1-8 alkyl, (d) C.sub.3-8 cycloalkyl, (e) C.sub.3-8 cycloheteroalkyl, (f) aryl C.sub.1-6 alkyl, (g) amino C.sub.0-6 alkyl, (h) C.sub.1-6 alkylamino C.sub.0-6 alkyl, (i) (C.sub.1-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (j) aryl C.sub.0-6 alkylamino C.sub.0-6 alkyl, (k) (aryl C.sub.0-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (l) C.sub.1-6 alkylthio, (m) aryl C.sub.0-6 alkylthio, (n) C.sub.1-6 alkylsulfinyl, (o) aryl C.sub.0-6 alkylsulfinyl, (p) C.sub.1-6 alkylsulfonyl, (q) aryl C.sub.0-6 alkylsulfonyl, (r) C.sub.1-6 alkoxy C.sub.0-6 alkyl, (s) aryl C.sub.0-6 alkoxy C.sub.0-6 alkyl, (t) hydroxycarbonyl C.sub.0-6 alkyl, (u) C.sub.1-6 alkoxycarbonyl C.sub.0-6 alkyl, (v) aryl C.sub.0-6 alkoxycarbonyl C.sub.0-6 alkyl, (w) hydroxycarbonyl C.sub.1-6 alkyloxy, (x) hydroxy C.sub.0-6 alkyl, (y) cyano, (z) nitro, (aa) perfluoroC.sub.1-4 alkyl, (bb) perfluoroC.sub.1-4 alkoxy, (cc) oxo, (dd) C.sub.1-6 alkylcarbonyloxy, (ee) aryl C.sub.0-6 alkylcarbonyloxy, (ff) alkyl C.sub.1-6 carbonylamino, (gg) aryl C.sub.0-6 alkylcarbonylamino, (hh) C.sub.1-6 alkylsulfonylamino, (ii) aryl C.sub.0-6 alkylsulfonylamino, (jj) C.sub.1-6 alkoxycarbonylamino, (kk) aryl C.sub.0-6 alkoxycarbonylamino, (ll) C.sub.1-6 alkylaminocarbonylamino, (mm) aryl C.sub.0-6 alkylaminocarbonylamino, (nn) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (oo) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (pp) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (qq) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, (rr) C.sub.0-6 alkylcarbonyl C.sub.0-6 alkyl, and (ss) spiro-C.sub.3-8 cycloalkyl; (6) cycloheteroalkyl, unsubstituted or substituted with one to three substituents selected from: (a) halogen, (b) aryl, (c) C.sub.1-8 alkyl, (d) C.sub.3-8 cycloalkyl, (e) C.sub.3-8 cycloheteroalkyl, (f) aryl C.sub.1-6 alkyl, (g) amino C.sub.0-6 alkyl, (h) C.sub.1-6 alkylamino C.sub.0-6 alkyl, (i) (C.sub.1-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (j) aryl C.sub.0-6 alkylamino C.sub.0-6 alkyl, (k) (aryl C.sub.0-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (l) C.sub.1-6 alkylthio, (m) aryl C.sub.0-6 alkylthio, (n) C.sub.1-6 alkylsulfinyl, (o) aryl C.sub.0-6 alkylsulfinyl, (p) C.sub.1-6 alkylsulfonyl, (q) aryl C.sub.0-6 alkylsulfonyl, (r) C.sub.1-6 alkoxy C.sub.0-6 alkyl, (s) aryl C.sub.0-6 alkoxy C.sub.0-6 alkyl, (t) hydroxycarbonyl C.sub.0-6 alkyl, (u) C.sub.1-6 alkoxycarbonyl C.sub.0-6 alkyl, (v) aryl C.sub.0-6 alkoxycarbonyl C.sub.0-6 alkyl, (w) hydroxycarbonyl C.sub.1-6 alkyloxy, (x) hydroxy C.sub.0-6 alkyl, (y) cyano, (z) nitro, (aa) perfluoroC.sub.1-4 alkyl, (bb) perfluoroC.sub.1-4 alkoxy, (cc) oxo, (dd) C.sub.1-6 alkylcarbonyloxy, (ee) aryl C.sub.0-6 alkylcarbonyloxy, (ff) alkyl C.sub.1-6 carbonylamino, (gg) aryl C.sub.0-6 alkylcarbonylamino, (hh) C.sub.1-6 alkylsulfonylamino, (ii) aryl C.sub.0-6 alkylsulfonylamino, (jj) C.sub.1-6 alkoxycarbonylamino, (kk) aryl C.sub.0-6 alkoxycarbonylamino, (ll) C.sub.1-6 alkylaminocarbonylamino, (mm) aryl C.sub.0-6 alkylaminocarbonylamino, (nn) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (oo) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (pp) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (qq) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, and (rr) C.sub.0-6 alkylcarbonyl C.sub.0-6 alkyl, and (ss) spiro C.sub.3-8 cycloalkyl provided that any heteroatom substituent is bonded to a carbon atom in the cycloheteroalkyl ring; R.sup.3 is selected from H and C.sub.1-8 alkyl, or R.sup.2 and R.sup.3, together with the nitrogen atom to which they are attached, form a 5- to 7-membered heterocyclic ring, optionally containing one or two additional heteroatoms selected from N, S, and O, optionally having one or more degrees of unsaturation, optionally fused to a 6-membered heteroaromatic or aromatic ring, either unsubstituted or substituted with one to three substituents selected from: (1) halogen, (2) aryl, (3) C.sub.1-8 alkyl, (4) C.sub.3-8 cycloalkyl, (5) C.sub.3-8 cycloheteroalkyl, (6) aryl C.sub.1-6 alkyl, (7) amino C.sub.0-6 alkyl, (8) C.sub.1-6 alkylamino C.sub.0-6 alkyl, (9) (C.sub.1-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (10) aryl C.sub.0-6 alkylamino C.sub.0-6 alkyl, (11) (aryl C.sub.0-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (12) C.sub.1-6 alkylthio, (13) aryl C.sub.0-6 alkylthio, (14) C.sub.1-6 alkylsulfinyl, (15) aryl C.sub.0-6 alkylsulfinyl, (16) C.sub.1-6 alkylsulfonyl, (17) aryl C.sub.0-6 alkylsulfonyl, (18) C.sub.1-6 alkoxy C.sub.0-6 alkyl, (19) aryl C.sub.0-6 alkoxy C.sub.0-6 alkyl, (20) hydroxycarbonyl C.sub.0-6 alkyl, (21) C.sub.1-6 alkoxycarbonyl C.sub.0-6 alkyl, (22) aryl C.sub.0-6 alkoxycarbonyl C.sub.0-6 alkyl, (23) hydroxycarbonyl C.sub.1-6 alkyloxy, (24) hydroxy C.sub.0-6 alkyl, (25) cyano, (26) nitro, (27) perfluoroC.sub.1-4 alkyl, (28) perfluoroC.sub.1-4 alkoxy, (29) oxo, (30) C.sub.1-6 alkylcarbonyloxy, (31) aryl C.sub.0-6 alkylcarbonyloxy, (32) C.sub.1-6 alkyl carbonylamino, (33) aryl C.sub.0-6 alkylcarbonylamino, (34) C.sub.1-6 alkylsulfonylamino, (35) aryl C.sub.0-6 alkylsulfonylamino, (36) C.sub.1-6 alkoxycarbonylamino, (37) aryl C.sub.0-6 alkoxycarbonylamino, (38) C.sub.1-6 alkylaminocarbonylamino, (39) aryl C.sub.0-6 alkylaminocarbonylamino, (40) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (41) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (42) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (43) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, and (44) spiro-C.sub.3-8 cycloalkyl provided that any heteroatom substituent is bonded to a carbon atom in the heterocyclic ring; R.sup.4 and R.sup.5 are each independently selected from (1) hydrogen, (2) halogen, (3) aryl, (4) C.sub.1-8 alkyl, (5) C.sub.3-8 cycloalkyl, (6) C.sub.3-8 cycloheteroalkyl, (7) aryl C.sub.1-6 alkyl, (8) amino C.sub.0-6 alkyl, (9) C.sub.1-6 alkylamino C.sub.0-6 alkyl, (10) (C.sub.1-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (11) aryl C.sub.0-6 alkylamino C.sub.0-6 alkyl, (12) (aryl C.sub.0-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (13) C.sub.1-6 alkylthio, (14) aryl C.sub.0-6 alkylthio, (15) C.sub.1-6 alkylsulfinyl, (16) aryl C.sub.0-6 alkylsulfinyl, (17) C.sub.1-6 alkylsulfonyl, (18) aryl C.sub.0-6 alkylsulfonyl, (19) C.sub.1-6 alkoxy C.sub.0-6 alkyl, (20) aryl C.sub.0-6 alkoxy C.sub.0-6 alkyl, (21) hydroxycarbonyl C.sub.0-6 alkyl, (22) C.sub.1-6 alkoxycarbonyl C.sub.0-6 alkyl, (23) aryl C.sub.0-6 alkoxycarbonyl C.sub.0-6 alkyl, (24) hydroxycarbonyl C.sub.1-6 alkyloxy, (25) hydroxy C.sub.0-6 alkyl, (26) cyano, (27) nitro, (28) perfluoroC.sub.1-4 alkyl, (29) perfluoroC.sub.1-4 alkoxy, (30) C.sub.0-6 alkylcarbonyl C.sub.0-6 alkyl, (31) C.sub.1-6 alkylcarbonyloxy, (32) aryl C.sub.0-6 alkylcarbonyloxy, (33) C.sub.1-6 alkyl carbonylamino, (34) aryl C.sub.0-6 alkylcarbonylamino, (35) C.sub.1-6 alkylsulfonylamino, (36) aryl C.sub.0-6 alkylsulfonylamino, (37) C.sub.1-6 alkoxycarbonylamino, (38) aryl C.sub.0-6 alkoxycarbonylamino, (39) C.sub.1-6 alkylaminocarbonylamino, (40) aryl C.sub.0-6 alkylaminocarbonylamino, (41) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (42) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (43) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, and (44) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy; or, R.sup.4 and R.sup.5 together form an oxo group or .dbd.CH--R.sup.6 or a spiro C.sub.3-7 cycloalkyl ring, unsubstituted or substituted with R.sup.6 ; R.sup.6 is selected from: (1) hydrogen, and (2) C.sub.1-4 alkyl; or a pharmaceutically acceptable salt thereof. 3. The method according to claim 2 wherein the condition is osteoporosis. 4. The method according to claim 2 wherein: R.sup.1 is selected from: (1) C.sub.1-2 alkyl, (2) C.sub.3-6 cycloalkyl and (3) trifluoromethyl; R.sup.3 is hydrogen; and R.sup.4 and R.sup.5 are each hydrogen. 5. The method according to claim 4 wherein: R.sup.1 is selected from, (1) methyl, and (2) cyclopropyl; R.sup.2 is selected from, (1) aryl, either unsubstituted or substituted with one to three substituents selected from: (a) halogen, (b) aryl, (c) C.sub.1-6 alkyl, (d) C.sub.1-6 alkoxy, (e) cyano, (f) hydroxy, (g) trifluoromethyl, (h) perfluoroC.sub.2-4 alkyl, and (i) trifluoromethoxy; (2) C.sub.1-6 alkyl, either unsubstituted or substituted with one to three substituents selected from: (a) fluoro, (b) aryl, (c) C.sub.5-6 heteroalkyl, (d) amino, (e) C.sub.1-6 alkylamino, (f) (C.sub.1-6 alkyl).sub.2 amino, (g) C.sub.1-4 alkoxy, (h) hydroxy, (i) trifluoromethoxy, and (j) oxo; (3) C.sub.3-8 cycloalkyl, either unsubstituted or substituted with one to three substituents selected from: (a) fluoro, (b) C.sub.1-4 alkyl, (c) trifluoromethyl, (d) aryl, (e) hydroxy, (f) C.sub.1-3 alkoxy, (g) oxo, and (h) spiro-C.sub.3-8 cycloalkyl. 6. The method according to claim 4, wherein: R.sup.1 is selected from, (1) methyl, (2) cyclopropyl, and (3) trifluoromethyl; R.sup.2 is selected from: (1) aryl, substituted by one to three substituents selected from: (a) fluoro, (b) chloro, (c) bromo, (d) phenyl, (e) methyl, (f) ethyl, (g) benzyl, (h) amino, (i) cyano, (j) morpholinyl, (k) nitro, (l) methoxy, (m) methylthio, (n) hydroxy, (o) trifluoromethyl, (p) trifluoromethoxy, (q) formyl, (r) acetyl, and (s) oxo; (2) C.sub.1-8 alkyl, unsubstituted or substituted with one or two substituents independently selected from: (a) fluoro, (b) chloro, (c) phenyl, (d) thienyl, (e) pyrazinyl, (f) C.sub.3-6 cycloalkyl, (g) C.sub.5-6 cycloheteroalkyl, (h) amino, (i) C.sub.1-4 alkylamino, (j) (C.sub.1-4 alkyl).sub.2 amino, (k) benzylamino, (l) phenylamino, (m) (aryl C.sub.0-1 alkyl).sub.2 amino, (n) methylthio, (o) methoxy, (p) hydroxycarbonyl, (q) C.sub.1-6 alkoxycarbonyl, (r) phenyl C.sub.0-1 alkoxycarbonyl, (s) hydroxy, (t) trifluoromethyl, (u) trifluoromethoxy, (v) oxo, and (w) methylcarbonyloxy (3) perfluoroalkyl selected from trifluromethyl and perfluoroethyl; (4) C.sub.3-8 cycloalkyl, either unsubstituted or substituted with one to two substituents selected from: (a) fluoro, (b) chloro, (c) phenyl, (d) C.sub.1-4 alkyl, (e) cyclopropyl, (f) cyclohexyl, (g) benzyl, (h) amino, (i) C.sub.1-3 alkylamino, (j) C.sub.1-3 alkoxy, (k) hydroxy, (l) trifluoromethyl, (m) trifluoromethoxy, (n) oxo, (o) methylcarbonyloxy, (p) methylcarbonylamino, (q) methoxycarbonylamino, (r) methylaminocarbonylamino, (s) spiro C.sub.3-8 cycloalkyl; (5) cycloheteroalkyl, either unsubstituted or substituted with one to two substituents selected from: (a) fluoro, (b) chloro, (c) phenyl, (d) C.sub.1-4 alkyl, (e) benzyl, (f) amino, (g) C.sub.1-3 alkylamino, (h) C.sub.1-3 alkoxy, (i) hydroxy, (j) trifluoromethyl, (k) trifluoromethoxy, and (l) oxo; cycloheteroalkyl is selected from: piperidinyl, pyrrolidinyl, morpholinyl and octahydro-2H-quinolizinyl; aryl is selected from phenyl, quinolinyl, pyridyl, pyrazolyl, benzamidazolyl, imidazolyl, furyl, naphthyl, indanyl, thienyl, pyrazinyl, benzothienyl, 3,4-dihydro-1(1H)-isoquinolinyl, 1-8-tetrahydronaphthyridinyl, imidazo[1,2-a]pyridinyl, 2-oxo-2,3,4,5-tetrahydro-1H-benzo[B]azepinyl, quinoxalinyl, imidazo[1,2-a]pyrimidinyl, 2-3-cyclopentenopyridinyl, 1-(2H)-phthalazinyl, 1,2,3,4-tetrahydroquinolinyl, oxindolyl, isoquinolinyl, imidazo[2,1-b][1,3]thiazolyl, 2,3-dihydroimidazo[2,1-b][1,3]thiazolyl, and indolyl; and pharmaceutically acceptable salts thereof. 7. The method according to claim 1 wherein the compound is selected from: (1) N-(phenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (2) N-(2-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (3) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (4) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (5) N-(2-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (6) N-(2-biphenyl)-3-oxo-4-methyl-4-aza-50.alpha.-androst-1-ene-17.beta.-carbo xamide, (7) N-(4-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (8) N-(3-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (9) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (10) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (11) N-(3-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (12) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (13) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (14) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (15) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (16) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (17) N-(2-methyl-4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (18) N-(4-methoxy-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (19) N-(4-chloro-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (20) N-(2,4-dimethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (21) N-(3-bromo-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (22) N-(2,2,2-trifluoroethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (23) N-(2-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (24) N-(butyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (25) N-(5-methyl-2-pyridinyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (26) N-(4-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (27) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (28) N-(4-bromo-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst- 1-ene-17.beta.-carboxamide, (29) N-(4-chloro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (30) N-(2,4-dichlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (31) N-(3-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (32) N-(4-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (33) N-(5-fluoro-2-pyridinyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (34) N-(5-chloro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (35) N-(benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (36) N-((S)-.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (37) N-((R)-.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (38) N-(2-phenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (39) N-(1-(3-phenylpropyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (40) N-(3-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (41) N-(2-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (42) N-(2-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (43) N-(3-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (44) N-(3-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (45) N-(4-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (46) N-(3-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (47) N-(2-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (48) N-(cyclohexylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (49) N-(3-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (50) N-(2-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (51) N-(3-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (52) N-(4-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (53) N-(3-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (54) N-(3-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (55) N-(4-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (56) N-(2-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (57) N-(4-methoxylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (58) N-(4-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (59) N-((R)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (60) N-((S)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (61) N-(3-(1-pyrrolidin-2-one)-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst- 1-ene 17.beta.-carboxamide, (62) N-(2-furanylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (63) N-(1-naphthylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (64) N-(2-(4-imidazoylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (65) N-(2-(3-indolylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (66) N-(5-indolyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (67) N-((1,2-methylenedioxy)-4-benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1- ene-17.beta.-carboxamide, (68) N-(1,2-diphenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (69) N-(2-(1-hydroxy-1-phenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-en e-17.beta.-carboxamide, (70) N-(2-(2-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (71) N-(3-(1-imidazolyl)-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (72) N-(2-(2-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (73) N-(2-methoxyethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (74) N-(4-fluoro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (75) N-(2,4-difluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (76) N-(4-fluoro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (77) N-(4-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (78) N-(2-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (79) N-(3-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (80) N-(3,4-difluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (81) N-(4-dimethylaminobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (82) N-(2-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (83) N-(2-benzamidazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (84) N-(1-(4-phenylbutyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (85) N-(3,5-dimethoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (86) N-(2-(2-pyridinylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (87) N-(2-methyl-5-pyrazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (88) N-(2-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (89) N-(2-(2-thiophenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (90) N-(1-(1-naphthyl)-1(R)-ethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (91) N-(2-(3-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (92) N-(2-(2-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (93) N-(2-(4-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (94) N-(4-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (95) N-(2-(3-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (96) N-(2-(3,4-methylenedioxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (97) N-(2-thiophenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (98) N-(2-(4-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (99) N-(2-aminobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (100) N-(2-(4-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (101) N-((1S, 2R) 2-hydroxy-1-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (102) N-(2-dimethylaminoethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (103) N-(phenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (104) N-(2-chlorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (105) N-(2-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (106) N-(2-trifluoromethoxyphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (107) N-(2-methoxyphenyl)-3-oxo-4-ethyl-4-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (108) N-(benzyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (109) N-(2-fluorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (110) N-(1,1,1-trifluoroethyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (111) N-(2-propyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxami de, (112) N-(2-biphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (113) N-(2-acetylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (114) N-(3-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (115) N-(2-pyridinyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (116) N-(3-pyridinyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (117) N-(2-methylsulfonylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (118) N-(2-methylsulfoxyphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (119) N-(phenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (120) N-(2-chlorophenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (121) N-(2-trifluoromethylphenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (122) N-(3-methylphenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (123) N-(2-methylphenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (124) N-(2-cyanophenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.alpha.-car boxamide, (125) N-(2-benzoylphenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (126) N-(1,1,1-trifluoroethyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (127) N-(phenyl)-3-oxo-4-benzyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (128) N-(2-chlorophenyl)-3-oxo-4-benzyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (129) N-(2-trifluoromethylphenyl)-3-oxo-4-benzyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (130) N-(phenyl)-3-oxo-4-phenyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (131) N-(2-trifluoromethylphenyl)-3-oxo-4-phenyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (132) N-(2-chlorophenyl)-3-oxo-4-phenyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (133) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (134) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (135) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.b eta.-carboxamide, (136) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (137) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (138) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (139) N-(phenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carboxamide, (140) N-(2-methoxyphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (141) N-(2-propyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carboxamide, (142) N-(2-biphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carboxamid e, (143) N-(benzyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carboxamide, (144) N-(2-fluorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carbox amide, (145) N-(1,1,1-trifluoroethyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.- carboxamide, (146) N-(4-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.bet a.-carboxamide, (147) N-(1,1,1-trifluoroethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.be ta.-carboxamide, (148) N-(phenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-carboxamid e, (149) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (150) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (151) N-(4-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (152) N-(2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (153) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (154) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (155) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (156) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (157) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (158) N-(2-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (159) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (160) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (161) N-(phenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.beta.-carbo xamide, (162) N-(2-trifluoromethylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-e ne-17.beta.-carboxamide, (163) N-(2-fluorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (164) N-(3-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (165) N-(3-trifluoromethylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-e ne-17.beta.-carboxamide, (166) N-(4-trifluoromethylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-e ne-17.beta.-carboxamide, (167) N-(2-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (168) N-(4-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (169) N-(3-fluorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (170) N-(4-fluorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (171) N-(2-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (172) N-(3-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (173) N-(4-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, and (174) N-(1,1,1-trifluoroethyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene- 17.beta.-carboxamide, and pharmaceutically acceptable salts thereof. 8. The method according to claim 7 wherein the compound is selected from: (1) N-(phenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (2) N-(2-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (3) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (4) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (5) N-(2-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (6) N-(2-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (7) N-(4-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (8) N-(3-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (9) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (10) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (11) N-(3-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (12) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (13) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (14) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (15) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (16) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (17) N-(2-methyl-4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (18) N-(4-methoxy-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (19) N-(4-chloro-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (20) N-(2,4-dimethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (21) N-(3-bromo-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (22) N-(2,2,2-trifluoroethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (23) N-(2-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (24) N-(butyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (25) N-(5-methyl-2-pyridinyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (26) N-(4-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (27) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (28) N-(4-bromo-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst- 1-ene-17.beta.-carboxamide, (29) N-(4-chloro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (30) N-(2,4-dichlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (31) N-(3-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (32) N-(4-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (33) N-(5-chloro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (34) N-(benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (35) N-((S)-.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (36) N-((R)-.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (37) N-(2-phenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (38) N-(1-(3-phenylpropyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (39) N-(3-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (40) N-(2-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (41) N-(2-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (42) N-(3-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (43) N-(3-chlorobenzyl)-3-oxo-4-methyl-4-aza-50.alpha.-androst-1-ene-17.beta.-c arboxamide, (44) N-(4-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (45) N-(3-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (46) N-(2-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (47) N-(cyclohexylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (48) N-(3-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (49) N-(2-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (50) N-(3-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (51) N-(4-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (52) N-(3-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (53) N-(3-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (54) N-(4-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (55) N-(2-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (56) N-(4-methoxylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (57) N-(4-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (58) N-((R)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (59) N-((S)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (60) N-(2-furanylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (61) N-(1-naphthylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (62) N-(2-(3-indolylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (63) N-(5-indolyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (64) N-((1,2-methylenedioxy)-4-benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1- ene-17.beta.-carboxamide, (65) N-(1,2-diphenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (66) N-(2-(1-hydroxy-1-phenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-en e-17.beta.-carboxamide, (67) N-(2-(2-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (68) N-(2-(2-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.alpha.-carboxamide, (69) N-(2-methoxyethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (70) N-(4-fluoro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (71) N-(2,4-difluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (72) N-(4-fluoro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (73) N-(2-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (74) N-(3-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (75) N-(3,4-difluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (76) N-(4-dimethylaminobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (77) N-(2-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (78) N-(2-benzamidazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (79) N-(1-(4-phenylbutyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (80) N-(3,5-dimethoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (81) N-(2-(2-pyridinylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (82) N-(2-methyl-5-pyrazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (83) N-(2-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (84) N-(2-(2-thiophenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (85) N-(2-(3-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (86) N-(2-(2-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (87) N-(2-(4-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (88) N-(2-(4-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (89) N-(2-(3-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (90) N-(2-(3,4-methylenedioxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (91) N-(2-thiophenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (92) N-(2-(4-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (93) N-(2-(2-aminobenzyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (94) N-(2-(4-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .alpha.-carboxamide, (95) N-((1S, 2R) 2-hydroxy-1-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (96) N-(2-chlorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (97) N-(2-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (98) N-(benzyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (99) N-(2-fluorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (100) N-(3-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (101) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (102) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (103) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.b eta.-carboxamide, (104) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (105) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (106) N-(phenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-carboxamid e, (107) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (108) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (109) N-(2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (110) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (111) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (112) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (113) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (114) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.alpha.- carboxamide, (115) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (116) N-(phenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.beta.-carbo xamide, (117) N-(3-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (118) N-(3-trifluoromethylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-e ne-17.beta.-carboxamide, (119) N-(2-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (120) N-(3-fluorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (121) N-(2-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (122) N-(3-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.alp ha.-carboxamide. 9. The method according to claim 8, wherein the compound is selected from: (1) N-(phenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (2) N-(2-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (3) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .alpha.-carboxamide, (4) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (5) N-(2-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (6) N-(2-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (7) N-(4-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (8) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (9) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (10) N-(3-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (11) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (12) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-Carboxamide, (13) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (14) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (15) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (16) N-(2-methyl-4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (17) N-(4-methoxy-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (18) N-(4-chloro-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (19) N-(2,4-dimethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (20) N-(3-bromo-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (21) N-(2,2,2-trifluoroethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (22) N-(2-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (23) N-(butyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (24) N-(5-methyl-2-pyridinyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (25) N-(4-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (26) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (27) N-(4-bromo-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst- 1-ene-17.beta.-carboxamide, (28) N-(4-chloro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (29) N-(2,4-dichlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (30) N-(3-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (31) N-(4-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (32) N-(5-chloro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (33) N-(benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (34) N-((S)-.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (35) N-((R)-.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (36) N-(2-phenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (37) N-(1-(3-phenylpropyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (38) N-(2-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (39) N-(2-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (40) N-(3-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (41) N-(4-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (42) N-(3-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (43) N-(2-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (44) N-(cyclohexylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (45) N-(3-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (46) N-(2-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (47) N-(3-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (48) N-(4-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (49) N-(3-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (50) N-(3-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (51) N-(4-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (52) N-(2-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (53) N-(4-methoxylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (54) N-(4-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (55) N-((R)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (56) N-((S)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (57) N-(2-furanylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (58) N-(1-naphthylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (59) N-(2-(3-indolylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (60) N-(5-indolyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (61) N-((1,2-methylenedioxy)-4-benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1- ene-17.beta.-carboxamide, (62) N-(1,2-diphenylethyl)-3-oxo-4-methyl-4-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (63) N-(2-(2-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (64) N-(2-(2-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (65) N-(4-fluoro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (66) N-(2,4-difluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (67) N-(4-fluoro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (68) N-(2-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (69) N-(3-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (70) N-(3,4-difluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (71) N-(4-dimethylaminobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (72) N-(2-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (73) N-(2-benzamidazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (74) N-(3,5-dimethoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (75) N-(2-(2-pyridinylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (76) N-(2-methyl-5-pyrazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (77) N-(2-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (78) N-(2-(2-thiophenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (79) N-(2-(3-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (80) N-(2-(2-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (81) N-(2-(4-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (82) N-(2-(4-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (83) N-(2-(3-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (84) N-(2-(3,4-methylenedioxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (85) N-(2-thiophenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (86) N-(2-(4-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (87) N-(2-(2-aminobenzyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (88) N-(2-(4-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (89) N-((1S, 2R) 2-hydroxy-1-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (90) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (91) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (92) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (93) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (94) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (95) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (96) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (97) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (98) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (99) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide. 10. The method according to claim 1 wherein the compound is selected from: (1) N-(phenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (2) N-(2-chlorophenyl)-3-oxo-4-methyl-4-aza-5c.alpha.-androst-1-ene-17.beta.-c arboxamide, (3) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (4) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5u-androst-1-ene-17.beta.-carboxam ide, (5) N-(2-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.ca rboxamide, (6) N-(2-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (7) N-(4-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (8) N-(3-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (9) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (10) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (11) N-(3-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (12) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (13) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (14) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (15) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (16) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (17) N-(2-methyl-4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (18) N-(4-methoxy-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (19) N-(4-chloro-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (20) N-(2,4-dimethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (21) N-(3-bromo-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (22) N-(2,2,2-trifluoroethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (23) N-(2-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (24) N-(butyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (25) N-(5-methyl-2-pyridinyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (26) N-(4-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (27) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (28) N-(4-bromo-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst- 1-ene-17.beta.-carboxamide, (29) N-(4-chloro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (30) N-(2,4-dichlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (31) N-(3-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (32) N-(4-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (33) N-(5-fluoro-2-pyridinyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (34) N-(5-chloro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (35) N-(benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (36) N-((S)-.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (37) N-((R)-.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (38) N-(2-phenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (39) N-(1-(3-phenylpropyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (40) N-(3-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (41) N-(2-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (42) N-(2-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (43) N-(3-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (44) N-(3-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (45) N-(4-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (46) N-(3-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (47) N-(2-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (48) N-(cyclohexylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (49) N-(3-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (50) N-(2-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (51) N-(3-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (52) N-(4-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (53) N-(3-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (54) N-(3-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (55) N-(4-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (56) N-(2-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (57) N-(4-methoxylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (58) N-(4-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (59) N-((R)-2-phenyl-1-propyl-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (60) N-((S)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (61) N-(3-(1-pyrrolidin-2-one)-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst- 1-ene-17.beta.-carboxamide, (62) N-(2-furanylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (63) N-(1-naphthylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (64) N-(2-(4-imidazoylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (65) N-(2-(3-indolylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (66) N-(5-indolyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (67) N-((1,2-methylenedioxy)-4-benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1- ene-17.beta.-carboxamide, (68) N-(1,2-diphenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (69) N-(2-(1-hydroxy-1-phenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-en e-17.beta.-carboxamide, (70) N-(2-(2-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (71) N-(3-(1-imidazolyl)-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (72) N-(2-(2-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (73) N-(2-methoxyethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (74) N-(4-fluoro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (75) N-(2,4-difluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (76) N-(4-fluoro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (77) N-(4-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (78) N-(2-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (79) N-(3-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (80) N-(3,4-difluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (81) N-(4-dimethylaminobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (82) N-(2-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (83) N-(2-benzamidazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (84) N-(1-(4-phenylbutyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (85) N-(3,5-dimethoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (86) N-(2-(2-pyridinylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (87) N-(2-methyl-5-pyrazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (88) N-(2-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (89) N-(2-(2-thiophenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (90) N-(1-(1-naphthyl)-1 (R)-ethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (91) N-(2-(3-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (92) N-(2-(2-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (93) N-(2-(4-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (94) N-(4-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (95) N-(2-(3-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (96) N-(2-(3,4-methylenedioxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (97) N-(2-thiophenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (98) N-(2-(4-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (99) N-(2-aminobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (100) N-(2-(4-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (101) N-((1S, 2R) 2-hydroxy-1-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (102) N-(2-dimethylaminoethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (103) N-(phenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (104) N-(2-chlorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (105) N-(2-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (106) N-(2-trifluoromethoxyphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (107) N-(2-methoxyphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (108) N-(benzyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (109) N-(2-fluorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (110) N-(1,1,1-trifluoroethyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (111) N-(2-propyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxami de, (112) N-(2-biphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (113) N-(2-acetylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (114) N-(3-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (115) N-(2-pyridinyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (116) N-(3-pyridinyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (117) N-(2-methylsulfonylphenyl)-3-oxo-4-ethyl-4-aza-5a-androst-1-ene-17.beta.-c arboxamide, (118) N-(2-methylsulfoxyphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (119) N-(phenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (120) N-(2-chlorophenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (121) N-(2-trifluoromethylphenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (122) N-(3-methylphenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (123) N-(2-methylphenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (124) N-(2-cyanophenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carb oxamide, (125) N-(2-benzoylphenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (126) N-(1,1,1-trifluoroethyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (127) N-(phenyl)-3-oxo-4-benzyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (128) N-(2-chlorophenyl)-3-oxo-4-benzyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (129) N-(2-trifluoromethylphenyl)-3-oxo-4-benzyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (130) N-(phenyl)-3-oxo-4-phenyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (131) N-(2-trifluoromethylphenyl)-3-oxo-4-phenyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (132) N-(2-chlorophenyl)-3-oxo-4-phenyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (133) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (134) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (135) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.b eta.-carboxamide, (136) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (137) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (138) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (139) N-(phenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carboxamide, (140) N-(2-methoxyphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (141) N-(2-propyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carboxamide, (142) N-(2-biphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carboxamid e, (143) N-(benzyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carboxamide, (144) N-(2-fluorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carbox amide, (145) N-(1,1,1-trifluoroethyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.- carboxamide, (146) N-(4-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.bet a.-carboxamide, (147) N-(1,1,1 -trifluoroethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-carb oxamide, (148) N-(phenyl )-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-carboxamide, (149) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (150) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (151) N-(4-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (152) N-(2-methylphenyl-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-car boxamide, (153) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (154) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (155) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (156) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (157) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (158) N-(2-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (159) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (160) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (161) N-(phenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.beta.-carbo xamide, (162) N-(2-trifluoromethylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-e ne-17.beta.-carboxamide, (163) N-(2-fluorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene 17.beta.-carboxamide, (164) N-(3-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (165) N-(3-trifluoromethylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-e ne-17.beta.-carboxamide, (166) N-(4-trifluoromethylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-e ne-17.beta.-carboxamide, (167) N-(2-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (168) N-(4-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (169) N-(3-fluorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (170) N-(4-fluorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (171) N-(2-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (172) N-(3-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (173) N-(4-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, and (174) N-(1,1,1-trifluoroethyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene- 17.beta.-carboxamide, and pharmaceutically acceptable salts thereof. and pharmaceutically acceptable salts thereof. 11. The method according to claim 10 wherein the compound is detected (1) N-(phenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (2) N-(2-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (3) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (4) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (5) N-(2-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (6) N-(2-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (7) N-(4-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (8) N-(3-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (9) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (10) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (11) N-(3-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (12) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (13) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (14) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (15) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (16) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (17) N-(2-methyl-4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (18) N-(4-methoxy-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (19) N-(4-chloro-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (20) N-(2,4-dimethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (21) N-(3-bromo-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (22) N-(2,2,2-trifluoroethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (23) N-(2-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (24) N-(butyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (25) N-(5-methyl-2-pyridinyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (26) N-(4-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (27) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (28) N-(4-bromo-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst- 1-ene-17.beta.-carboxamide, (29) N-(4-chloro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (30) N-(2,4-dichlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (31) N-(3-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (32) N-(4-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (33) N-(5-chloro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (34) N-(benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (35) N-((S)-.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (36) N-((R)-.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (37) N-(2-phenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (38) N-(1-(3-phenylpropyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (39) N-(3-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (40) N-(2-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (41) N-(2-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (42) N-(3-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (43) N-(3-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (44) N-(4-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (45) N-(3-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (46) N-(2-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (47) N-(cyclohexylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (48) N-(3-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (49) N-(2-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (50) N-(3-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (51) N-(4-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (52) N-(3-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (53) N-(3-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (54) N-(4-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (55) N-(2-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (56) N-(4-methoxylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (57) N-(4-chlorophenyl)-3-oxo-4-methyl-4-aza-.alpha.-androst-1-ene-17.beta.-car boxamide, (58) N-((R)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (59) N-((S)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (60) N-(2-furanylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (61) N-(1-naphthylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (62) N-(2-(3-indolylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (63) N-(5-indolyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (64) N-((1,2-methylenedioxy)-4-benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1- ene-17.beta.-carboxamide, (65) N-(1,2-diphenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (66) N-(2-(1-hydroxy-1-phenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-en e-17.beta.-carboxamide, (67) N-(2-(2-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (68) N-(2-(2-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (69) N-(2-methoxyethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (70) N-(4-fluoro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (71) N-(2,4-difluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (72) N-(4-fluoro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (73) N-(2-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (74) N-(3-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (75) N-(3,4-difluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (76) N-(4-dimethylaminobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (77) N-(2-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (78) N-(2-benzamidazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (79) N-(1-(4-phenylbutyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (80) N-(3,5-dimethoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (81) N-(2-(2-pyridinylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (82) N-(2-methyl-5-pyrazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (83) N-(2-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (84) N-(2-(2-thiophenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (85) N-(2-(3-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (86) N-(2-(2-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (87) N-(2-(4-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (88) N-(4-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (89) N-(2-(3-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (90) N-(2-(3,4-methylenedioxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (91) N-(2-thiophenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (92) N-(2-(4-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (93) N-(2-(2-aminobenzyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (94) N-(2-(4-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (95) N-((1S, 2R) 2-hydroxy-1-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (96) N-(2-chlorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (97) N-(2-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (98) N-(benzyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (99) N-(2-fluorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (100) N-(3-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (101) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (102) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (103) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.b eta.-carboxamide, (104) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (105) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (106) N-(phenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-carboxamid e, (107) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (108) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (109) N-(2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (110) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (111) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (112) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (113) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (114) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (115) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (116) N-(phenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.beta.-carbo xamide, (117) N-(3-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (118) N-(3-trifluoromethylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-e ne-17.beta.-carboxamide, (119) N-(2-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (120) N-(3-fluorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (121) N-(2-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (122) N-(3-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide. 12. The method according to claim 11, wherein the compound is selected from: (1) N-(phenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (2) N-(2-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (3) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (4) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (5) N-(2-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (6) N-(2-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (7) N-(4-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (8) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (9) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (10) N-(3-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (11) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (12) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (13) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (14) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (15) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (16) N-(2-methyl-4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (17) N-(4-methoxy-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (18) N-(4-chloro-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (19) N-(2,4-dimethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (20) N-(3-bromo-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (21) N-(2,2,2-trifluoroethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (22) N-(2-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (23) N-(butyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (24) N-(5-methyl-2-pyridinyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (25) N-(4-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (26) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (27) N-(4-bromo-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst- 1-ene-17.beta.-carboxamide, (28) N-(4-chloro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.carboxamide, (29) N-(2,4-dichlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (30) N-(3-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (31) N-(4-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (32) N-(5-chloro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (33) N-(benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (34) N-((S)-.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (35) N-((R)-.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (36) N-(2-phenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (37) N-(1-(3-phenylpropyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (38) N-(2-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (39) N-(2-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (40) N-(3-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (41) N-(4-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (42) N-(3-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (43) N-(2-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (44) N-(cyclohexylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (45) N-(3-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (46) N-(2-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (47) N-(3-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (48) N-(4-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (49) N-(3-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (50) N-(3-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (51) N-(4-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (52) N-(2-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (53) N-(4-methoxylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (54) N-(4-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (55) N-((R)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (56) N-((S)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (57) N-(2-furanylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (58) N-(1-naphthylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (59) N-(2-(3-indolylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (60) N-(5-indolyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (61) N-((1,2-methylenedioxy)-4-benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1- ene-17.beta.-carboxamide, (62) N-(1,2-diphenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (63) N-(2-(2-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (64) N-(2-(2-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (65) N-(4-fluoro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (66) N-(2,4-difluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (67) N-(4-fluoro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (68) N-(2-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (69) N-(3-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst--1 ene-17.beta.-carboxamide, (70) N-(3,4-difluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (71) N-(4-dimethylaminobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (72) N-(2-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (73) N-(2-benzamidazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (74) N-(3,5-dimethoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (75) N-(2-(2-pyridinylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (76) N-(2-methyl-5-pyrazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (77) N-(2-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (78) N-(2-(2-thiophenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (79) N-(2-(3-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (80) N-(2-(2-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (81) N-(2-(4-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (82) N-(2-(4-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (83) N-(2-(3-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (84) N-(2-(3,4-methylenedioxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (85) N-(2-thiophenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (86) N-(2-(4-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (87) N-(2-(2-aminobenzyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (88) N-(2-(4-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (89) N-((1S, 2R) 2-hydroxy-1-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (90) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (91) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (92) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (93) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17-carboxamid e, (94) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (95) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (96) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (97) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (98) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (99) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide. 13. The method according to claim 2 wherein the compound is selected from: (1) N-(phenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (2) N-(2-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (3) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (4) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (5) N-(2-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (6) N-(2-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (7) N-(4-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (8) N-(3-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (9) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (10) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (11) N-(3-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (12) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (13) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (14) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (15) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (16) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (17) N-(2-methyl-4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (18) N-(4-methoxy-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (19) N-(4-chloro-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (20) N-(2,4-dimethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (21) N-(3-bromo-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (22) N-(2,2,2-trifluoroethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (23) N-(2-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (24) N-(butyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (25) N-(5-methyl-2-pyridinyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (26) N-(4-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (27) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (28) N-(4-bromo-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst- 1-ene-17.beta.-carboxamide, (29) N-(4-chloro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (30) N-(2,4-dichlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (31) N-(3-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (32) N-(4-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (33) N-(5-fluoro-2-pyridinyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (34) N-(5-chloro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (35) N-(benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (36) N-((S)-.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (37) N-((R)-(x-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (38) N-(2-phenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (39) N-(1-(3-phenylpropyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (40) N-(3-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (41) N-(2-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (42) N-(2-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (43) N-(3-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (44) N-(3-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (45) N-(4-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (46) N-(3-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (47) N-(2-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (48) N-(cyclohexylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (49) N-(3-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (50) N-(2-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (51) N-(3-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (52) N-(4-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (53) N-(3-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (54) N-(3-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (55) N-(4-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (56) N-(2-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (57) N-(4-methoxylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (58) N-(4-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (59) N-((R)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (60) N-((S)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (61) N-(3-(1-pyrrolidin-2-one)-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst- 1-ene-17.beta.-carboxamide, (62) N-(2-furanylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (63) N-(1-naphthylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (64) N-(2-(4-imidazoylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (65) N-(2-(3-indolylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (66) N-(5-indolyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (67) N-((1,2-methylenedioxy)-4-benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1- ene-17.beta.-carboxamide, (68) N-(1,2-diphenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (69) N-(2-(1-hydroxy-1-phenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-en e-17.beta.-carboxamide, (70) N-(2-(2-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (71) N-(3-(1-imidazolyl)-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (72) N-(2-(2-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (73) N-(2-methoxyethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (74) N-(4-fluoro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.carboxamide, (75) N-(2,4-difluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (76) N-(4-fluoro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (77) N-(4-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (78) N-(2-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (79) N-(3-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5-androst-1-ene-17.beta.-carboxam ide, (80) N-(3,4-difluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (81) N-(4-dimethylaminobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (82) N-(2-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.carboxam ide, (83) N-(2-benzamidazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (84) N-(1-(4-phenylbutyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (85) N-(3,5-dimethoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (86) N-(2-(2-pyridinylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (87) N-(2-methyl-5-pyrazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (88) N-(2-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (89) N-(2-(2-thiophenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (90) N-(1-(1-naphthyl)-1(R)-ethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (91) N-(2-(3-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (92) N-(2-(2-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (93) N-(2-(4-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (94) N-(4-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (95) N-(2-(3-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (96) N-(2-(3,4-methylenedioxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-andros t 1-ene-17.beta.-carboxamide, (97) N-(2-thiophenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (98) N-(2-(4-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (99) N-(2-aminobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (100) N-(2-(4-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (101) N-((I S, 2R) 2-hydroxy-1-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (102) N-(2-dimethylaminoethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (103) N-(phenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (104) N-(2-chlorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (105) N-(2-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (106) N-(2-trifluoromethoxyphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (107) N-(2-methoxyphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (108) N-(benzyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (109) N-(2-fluorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (110) N-(1,1,1-trifluoroethyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (111) N-(2-propyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxami de, (112) N-(2-biphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17-carboxamide, (113) N-(2-acetylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (114) N-(3-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (115) N-(2-pyridinyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (116) N-(3-pyridinyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (117) N-(2-methylsulfonylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (118) N-(2-methylsulfoxyphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (119) N-(phenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (120) N-(2-chlorophenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (121) N-(2-trifluoromethylphenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (122) N-(3-methylphenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (123) N-(2-methylphenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (124) N-(2-cyanophenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (125) N-(2-benzoylphenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (126) N-(1,1,1-trifluoroethyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (127) N-(phenyl)-3-oxo-4-benzyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (128) N-(2-chlorophenyl)-3-oxo-4-benzyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (129) N-(2-trifluoromethylphenyl)-3-oxo-4-benzyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (130) N-(phenyl)-3-oxo-4-phenyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (131) N-(2-trifluoromethylphenyl)-3-oxo-4-phenyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (132) N-(2-chlorophenyl)-3-oxo-4-phenyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (133) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (134) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (135) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.b eta.-carboxamide, (136) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (137) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (138) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (139) N-(phenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carboxamide, (140) N-(2-methoxyphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (141) N-(2-propyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carboxamide, (142) N-(2-biphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carboxamid e, (143) N-(benzyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carboxamide, (144) N-(2-fluorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carbox amide, (145) N-(1,1,1-trifluoroethyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.- carboxamide, (146) N-(4-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.bet a.-carboxamide, (147) N-(1,1,1-trifluoroethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.be ta.-carboxamide, (148) N-(phenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-carboxamid e, (149) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (150) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (151) N-(4-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (152) N-(2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (153) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (154) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (155) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (156) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (157) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (158) N-(2-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (159) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (160) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (161) N-(phenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.beta.-carbo xamide, (162) N-(2-trifluoromethylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-e ne-17.beta.-carboxamide, (163) N-(2-fluorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (164) N-(3-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (165) N-(3-trifluoromethylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-e ne-17.beta.-carboxamide, (166) N-(4-trifluoromethylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-e ne-17.beta.-carboxamide, (167) N-(2-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (168) N-(4-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (169) N-(3-fluorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (17) N-(4-fluorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (17.beta.) N-(2-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (172) N-(3-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (173) N-(4-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, and (174) N-(1,1,1-trifluoroethyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene- 17.beta.-carboxamide, and pharmaceutically acceptable salts thereof. 14. The method according to claim 13 wherein the compound is selected from: (1) N-(phenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (2) N-(2-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (3) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (4) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (5) N-(2-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (6) N-(2-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (7) N-(4-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (8) N-(3-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (9) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (10) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (11) N-(3-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (12) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (13) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (14) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (15) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (16) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (17) N-(2-methyl-4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (18) N-(4-methoxy-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (19) N-(4-chloro-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (20) N-(2,4-dimethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (21) N-(3-bromo-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (22) N-(2,2,2-trifluoroethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (23) N-(2-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (24) N-(butyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (25) N-(5-methyl-2-pyridinyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (26) N-(4-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (27) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (28) N-(4-bromo-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst- 1-ene-17.beta.-carboxamide, (29) N-(4-chloro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (30) N-(2,4-dichlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (31) N-(3-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (32) (N-(4-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (33) N-(5-chloro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (34) (N-(benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxami de, (35) N-((S)-a-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (36) N-((R)-.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (37) (N-(2-phenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (38) (N-(1-(3-phenylpropyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (39) (N-(3-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (40) N-(2-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (41) (N-(2-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (42) N-(3-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (43) (N-(3-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (44) (N-(4-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (45) (N-(3-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (46) (N-(2-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (47) (N-(cyclohexylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (48) N-(3-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (49) (N-(2-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (50) (N-(3-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (51) (N-(4-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (52) N-(3-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (53) N-(3-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (54) N-(4-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (55) N-(2-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (56) N-(4-methoxylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (57) N-(4-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (58) N-((R)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (59) N-((S)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (60) N-(2-furanylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (61) N-(1-naphthylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (62) N-(2-(3-indolylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (63) N-(5-indolyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (64) N-((1,2-methylenedioxy)-4-benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1- ene-17.beta.-carboxamide, (65) N-(1,2-diphenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (66) N-(2-(1-hydroxy-1-phenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-en e-17.beta.-carboxamide, (67) N-(2-(2-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (68) N-(2-(2-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (69) N-(2-methoxyethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (70) N-(4-fluoro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (71) N-(2,4-difluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (72) N-(4-fluoro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (73) N-(2-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (74) N-(3-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (75) N-(3,4-difluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (76) N-(4-dimethylaminobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (77) N-(2-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (78) N-(2-benzamidazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (79) N-(1-(4-phenylbutyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (80) N-(3,5-dimethoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (81) N-(2-(2-pyridinylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (82) N-(2-methyl-5-pyrazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (83) N-(2-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (84) N-(2-(2-thiophenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (85) N-(2-(3-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (86) N-(2-(2-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (87) N-(2-(4-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (88) N-(4-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (89) N-(2-(3-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (90) N-(2-(3,4-methylenedioxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (91) N-(2-thiophenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (92) N-(2-(4-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (93) N-(2-(2-aminobenzyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (94) N-(2-(4-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (95) N-((1S, 2R) 2-hydroxy-1-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17-carbox amide, (96) N-(2-chlorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (97) N-(2-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (98) N-(benzyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (99) N-(2-fluorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (100) N-(3-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (101) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (102) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (103) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.b eta.-carboxamide, (104) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (105) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (106) N-(phenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-carboxamid e, (107) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (108) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (109) N-(2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (110) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (111) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (112) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (113) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (114) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (115) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (116) N-(phenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.beta.-carbo xamide, (117) N-(3-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (118) N-(3-trifluoromethylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-e ne-17.beta.-carboxamide, (119) N-(2-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (120) N-(3-fluorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (121) N-(2-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (122) N-(3-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide. 15. The method according to claim 14, wherein the compound is selected from: (1) N-(phenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (2) N-(2-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (3) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (4) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (5) N-(2-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (6) N-(2-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (7) N-(4-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (8) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (9) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (10) (N-(3-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (11) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (12) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (13) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (14) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (15) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (16) N-(2-methyl-4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (17) N-(4-methoxy-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (18) N-(4-chloro-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (19) N-(2,4-dimethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (20) N-(3-bromo-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (21) N-(2,2,2-trifluoroethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (22) N-(2-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (23) N-(butyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (24) N-(5-methyl-2-pyridinyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (25) N-(4-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (26) N-(3-fluorophenyl)-3-oxo-4-methyl-14-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (27) N-(4-bromo-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst- 1-ene-17.beta.-carboxamide, (28) N-(4-chloro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (29) N-(2,4-dichlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (30) N-(3-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (31) N-(4-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (32) N-(5-chloro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (33) N-(benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (34) N-((S)-(x-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (35) N-((R)-(.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (36) N-(2-phenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (37) N-(1-(3-phenylpropyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (38) N-(2-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (39) N-(2-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (40) N-(3-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (41) N-(4-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (42) N-(3-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (43) N-(2-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (44) N-(cyclohexylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (45) N-(3-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (46) N-(2-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (47) N-(3-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (48) N-(4-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (49) N-(3-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (50) N-(3-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (51) N-(4-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (52) N-(2-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (53) N-(4-methoxylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (54) N-(4-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (55) N-((R)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (56) N-((S)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (57) N-(2-furanylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (58) N-(1-naphthylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (59) N-(2-(3-indolylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (60) N-(5-indolyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (61) N-((1,2-methylenedioxy)-4-benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1- ene-17.beta.-carboxamide, (62) N-(1,2-diphenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (63) N-(2-(2-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (64) N-(2-(2-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (65) N-(4-fluoro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (66) N-(2,4-difluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (67) N-(4-fluoro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (68) N-(2-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (69) N-(3-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (70) N-(3,4-difluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (71) N-(4-dimethylaminobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (72) N-(2-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (73) N-(2-benzamidazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (74) N-(3,5-dimethoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (75) N-(2-(2-pyridinylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (76) N-(2-methyl-5-pyrazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (77) N-(2-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (78) N-(2-(2-thiophenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (79) N-(2-(3-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (80) N-(2-(2-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (81) N-(2-(4-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (82) N-(4-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (83) N-(2-(3-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (84) N-(2-(3,4-methylenedioxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (85) N-(2-thiophenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (86) N-(2-(4-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (87) N-(2-(2-aminobenzyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (88) N-(2-(4-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (89) N-((1S, 2R) 2-hydroxy-1-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (90) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (91) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (92) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (93) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (94) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (95) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (96) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (97) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (98) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, and (99) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide. 16. The method according to claim 1, wherein the androgen-dependent condition is osteoporosis. 17. The method according to claim 16, additionally comprising the administration of a bone-strengthening agent selected from: (a) estrogen or an estrogen derivative, alone or in combination with a progestin or progestin derivative, (b) a bisphosphonate, (c) an antiestrogen or a selective estrogen receptor modulator, (d) an osteoclast integrin inhibitor, (e) a cathepsin K inhibitor, (f) an HMG-CoA reductase inhibitor, (g) an osteoclast vacuolar ATPase inhibitor, (h) an antagonist of VFGF binding to osteoclast receptors, (i) a peroxisome proliferator-activated receptor .gamma., (j) calcitonin, (k) a calcium receptor antagonist, (l) parathyroid hormone, (m) a growth hormone secretagogue, (n) human growth hormone, (o) insulin-like growth factor, (p) a P-38 protein kinase inhibitor, (q) bone morphogenic protein, (r) an inhibitor of BMP antagonism, (s) a prostaglandin derivative, (t) vitamin D or vitamin D derivative, (u) vitamin K or vitamin K derivative, (v) ipriflavone, (w) fluoride salts, and (x) dietary calcium supplement. 18. The method according to claim 17, wherein: (a) the estrogen or estrogen derivative, alone or in combination with a progestin or progestin derivative is selected from: conjugated estrogen, equine estrogen, 17.beta.-estradiol, estrone, 17.beta.-ethynyl estradiol, alone or in combination with an agent selected from norethindrone and medroxyprogesterone acetate; (b) the bisphosphonate is selected from: (1) 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid, (2) N-methyl-4-amino-hydroxybutylidene-1,1-bisphosphonic acid, (3) 4-(N,N-dimethylamino-1-hydroxybutylidene-1,1-bisphosphonic acid, (4) 3-amino-1-hydroxypropylidene-1,1-bisphosphonic acid, (5) 3-(N,N-dimethylamino)-1-hydroxypropylidene-1,1-bisphosphonic acid, (6) 1-hydroxy-3-(N-methyl-N-pentylamino)propylidene-1,1-bisphosphonic acid, (7) 1-hydroxy-2-(3-pyridyl)ethylidene-1,1-bisphosphonic acid, (8) 4-(hydroxymethylene-1,1-bisphosphonic acid)piperidine, (9) (1-hydroxyethylidene)-bisphosphonate, (10) (dichloromethylene)-bisphosphonate, (11) [1-hydroxy-2-imidazopyridin-(1,2-a)-3-ylethylidene] bisphosphonate, (12) (6-amino-1-hydroxyhexylidene)bisphosphonate, and (13) [1-hydroxy-2-(1H-imidazole-1-yl)ethylidene]bisphosphonate; (c) the antiestrogen or selective estrogen receptor modulator is selected from: raloxifene, clomiphene, zuclomiphene, enclomiphene, nafoxidene, CI-680, CI-628, CN-55,945-27, Mer-25, U-11, 555A, U-100A tamoxifen, lasofoxifene, toremifene, azorxifene, EM-800, EM-652, TSE 424, droloxifene, idoxifene, and levormeloxifene; (d) the osteoclast integrin inhibitor is selected from an alphavbeta3 inhibitor or mixed alphavbeta.sub.3 and alphavbeta.sub.5 inhibitor; (e) the HMG-CoA reductase inhibitor is selected from lovastatin, simvastatin, dihydroxy-open acid simvastatin, pravastatin, fluvastatin, atorvastatin, cerivastatin, rosuvastatin, pitavastatin, and nisvastatin; (f) calcitonin is salmon calcitonin admininstered as a nasal spray; (g) bone morphogenic protein is selected from BMP 2, BMP 3, BMP 5, BMP 6, BMP 7, TGF beta, and GDF5; (h) insulin-like growth factor is selected from IGF I and IGF II alone or in combination with IGF binding protein 3; (i) the prostaglandin derivative is selected from agonists of prostaglandin receptor EP1, EP2, EP4, FP, and IP; (j) the fibroblast growth factor is selected from aFGF and bFGF; (k) parathyroid hormone or parathyroid hormone analog is selected from parathyroid hormone subcutaneous injection, human PTH, 1-84, 1-34 and other partial sequences, native or with substitutions; (l) vitamin D or vitamin D derivative is selected from: natural vitamin D, 25-OH-vitamin D3, 1.alpha.,25(OH).sub.2 vitamin D3, 1.alpha.-OH-vitamin D3, 1.alpha.-OH-vitamin D2, dihydrotachysterol, 26,27-F6-1.alpha.,25(OH)2 vitamin D3, 19-nor-1.alpha.,25(OH).sub.2 vitamin D3, 22-oxacalcitriol, calcipotriol, 1.alpha.,25(OH).sub.2 -16-ene-23-yne-vitamin D3 (Ro 23-7553), EB1089, 20-epi-1.alpha.,25(OH).sub.2 vitamin D3, KH1060, ED71, 1.alpha.,24(S)-(OH).sub.2 vitamin D3, and 1.alpha.,24(R)-(OH)2 vitamin D3; (m) the dietary calcium supplement is selected from calcium carbonate, calcium citrate, and natural calcium salts; (n) the fluoride salts are selected from: sodium fluoride and monosodium fluorophosphate (MFP); and pharmaceutically acceptable salts thereof. 19. The method according to claim 16, additionally comprising the administration of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid monosodium salt, trihydrate. 20. The method according to claim 16 wherein the compound of structural formula I is selected from: (1) N-(phenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (2) N-(2-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (3) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (4) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (5) N-(2-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (6) N-(2-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (7) N-(4-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (8) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (9) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (10) N-(3-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (I1) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (12) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (13) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (14) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (15) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (16) N-(2-methyl-4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (17) N-(4-methoxy-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17-carboxamide, (18) N-(4-chloro-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (19) N-(2,4-dimethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (20) N-(3-bromo-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (21) N-(2,2,2-trifluoroethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (22) N-(2-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (23) N-(butyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (24) N-(5-methyl-2-pyridinyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (25) N-(4-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-I1-ene-1 7.beta.-carboxamide, (26) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (27) N-(4-bromo-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst- 1-ene-17.beta.-carboxamide, (28) N-(4-chloro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (29) N-(2,4-dichlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (30) N-(3-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (31) N-(4-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (32) N-(5-chloro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (33) N-(benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (34) N-((S)-.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (35) N-((R)-.alpha.-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (36) N-(2-phenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (37) N-(1-(3-phenylpropyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (38) N-(2-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (39) N-(2-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (40) N-(3-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (41) N-(4-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (42) N-(3-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (43) N-(2-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.smallcircle.-androst-1-ene-17.b eta.-carboxamide, (44) N-(cyclohexylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (45) N-(3-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (46) N-(2-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (47) N-(3-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (48) N-(4-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (49) N-(3-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (50) N-(3-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (51) N-(4-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (52) N-(2-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (53) N-(4-methoxylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (54) N-(4-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (55) N-((R)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (56) N-((S)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (57) N-(2-furanylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (58) N-(1-naphthylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (59) N-(2-(3-indolylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (60) N-(5-indolyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (61) N-((1,2-methylenedioxy)-4-benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1- ene-17.beta.-carboxamide, (62) N-(1,2-diphenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (63) N-(2-(2-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (64) N-(2-(2-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (65) N-(4-fluoro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (66) N-(2,4-difluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (67) N-(4-fluoro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (68) N-(2-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (69) N-(3-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (70) N-(3,4-difluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (71) N-(4-dimethylaminobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (72) N-(2-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (73) N-(2-benzamidazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (74) N-(3,5-dimethoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (75) N-(2-(2-pyridinylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (76) N-(2-methyl-5-pyrazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (77) N-(2-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (78) N-(2-(2-thiophenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (79) N-(2-(3-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (80) N-(2-(2-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (81) N-(2-(4-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (82) N-(2-(4-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (83) N-(2-(3-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (84) N-(2-(3,4-methylenedioxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (85) N-(2-thiophenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (86) N-(2-(4-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (87) N-(2-(2-aminobenzyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (88) N-(2-(4-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (89) N-((1S, 2R) 2-hydroxy-1-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (90) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (91) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (92) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (93) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (94) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.beta.-androst-5-ene-17. beta.-carboxamide, (95) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (96) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (97) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (98) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (99) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, and pharmaceutically acceptable salts thereof. 21. A composition comprising a compound of structural formula I ##STR11## wherein: "a" and "b" are independently selected from a single bond and a double bond; R.sup.1 is selected from: (1) C.sub.1-3 alkyl, (2) C.sub.2-3 alkenyl, (3) C.sub.3-6 cycloalkyl, (4) C.sub.1-3 alkyl wherein one or more of the hydrogen atoms has been replaced with a fluorine atom, (5) aryl, and (6) aryl-C.sub.1-3 alkyl; R.sup.2 is selected from: (1) aryl, either unsubstituted or substituted with one to three substituents selected from: (a) halogen, (b) aryl, (c) C.sub.1-8 alkyl, (d) C.sub.3-8 cycloalkyl, (e) C.sub.3-8 cycloheteroalkyl, (f) aryl C.sub.1-6 alkyl, (g) amino C.sub.0-6 alkyl, (h) C.sub.1-6 alkylamino C.sub.0-6 alkyl, (i) (C.sub.1-6 alkyl)2amino C.sub.0-6 alkyl, (j) aryl C.sub.0-6 alkylamino C.sub.0-6 alkyl, (k) (aryl C.sub.0-6 alkyl)2amino C.sub.0-6 alkyl, (l) C.sub.1-6 alkylthio, (m) aryl C.sub.0-6 alkylthio, (n) C.sub.1-6 alkylsulfinyl, (o) aryl C.sub.0-6 alkylsulfinyl, (p) C.sub.1-6 alkylsulfonyl, (q) aryl C.sub.0-6 alkylsulfonyl, (r) C.sub.1-6 alkoxy C.sub.0-6 alkyl, (s) aryl C.sub.0-6 alkoxy C.sub.0-6 alkyl, (t) hydroxycarbonyl C.sub.0-6 alkyl, (u) C.sub.1-6 alkoxycarbonyl C.sub.0-6 alkyl, (v) aryl C.sub.0-6 alkoxycarbonyl C.sub.0-6 alkyl, (w) hydroxycarbonyl C.sub.1-6 alkyloxy, (x) hydroxy C.sub.0-6 alkyl, (y) cyano, (z) nitro, (aa) perfluoroC.sub.1-4 alkyl, (bb) perfluoroC.sub.1-4 alkoxy, (cc) oxo, (dd) C.sub.1-6 alkylcarbonyloxy, (ee) aryl C.sub.0-6 alkylcarbonyloxy, (ff) alkyl C.sub.1-6 carbonylamino, (gg) aryl C.sub.0-6 alkylcarbonylamino, (hh) C.sub.1-6 alkylsulfonylamino, (ii) aryl C.sub.0-6 alkylsulfonylamino, (jj) C.sub.1-6 alkoxycarbonylamino, (kk) aryl C.sub.0-6 alkoxycarbonylamino, (ll) C.sub.1-6 alkylaminocarbonylamino, (mm) aryl C.sub.0-6 alkylaminocarbonylamino, (nn) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (oo) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (pp) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (qq) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, (rr) C.sub.0-6 alkylcarbonyl C.sub.0-6 alkyl, and (ss) aryl C.sub.0-6 alkylcarbonyl C.sub.0-6 alkyl; (2) C.sub.1-8 alkyl, unsubstituted or substituted with one to three substituents independently selected from: (a) halogen, (b) aryl, (c) C.sub.1-8 alkyl, (d) C.sub.3-8 cycloalkyl, (e) C.sub.3-8 cycloheteroalkyl, (f) amino, (g) C.sub.1-6 alkylamino, (h) (C.sub.1-6 alkyl).sub.2 amino, (i) aryl C.sub.0-6 alkylamino, (j) (aryl C.sub.0-6 alkyl).sub.2 amino, (k) C.sub.1-6 alkylthio, (l) aryl C.sub.0-6 alkylthio, (m) C.sub.1-6 alkylsulfinyl, (n) aryl C.sub.0-6 alkylsulfinyl, (o) C.sub.1-6 alkylsulfonyl, (p) aryl C.sub.0-6 alkylsulfonyl, (q) C.sub.1-6 alkoxy, (r) aryl C.sub.0-6 alkoxy, (s) hydroxycarbonyl, (t) C.sub.1-6 alkoxycarbonyl, (u) aryl C.sub.0-6 alkoxycarbonyl, (v) hydroxycarbonyl C.sub.1-6 alkyloxy, (w) hydroxy, (x) cyano, (y) nitro, (z) perfluoroC.sub.1-4 alkyl, (aa) perfluoroC.sub.1-4 alkoxy, (bb) oxo, (cc) C.sub.1-6 alkylcarbonyloxy, (dd) aryl C.sub.0-6 alkylcarbonyloxy, (ee) alkyl C.sub.1-6 carbonylamino, (ff) aryl C.sub.0-6 alkylcarbonylamino, (gg) C.sub.1-6 alkylsulfonylamino, (hh) aryl C.sub.0-6 alkylsulfonylamino, (ii) C.sub.1-6 alkoxycarbonylamino, (j) aryl C.sub.0-6 alkoxycarbonylamino, (kk) C.sub.1-6 alkylaminocarbonylamino, (ll) aryl C.sub.0-6 alkylaminocarbonylamino, (mm) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (nn) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (oo) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (pp) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, and (qq) spiro-C.sub.3-8 -cycloalkyl; (3) perfluoroC.sub.1-8 alkyl, (4) C.sub.2-8 alkenyl, unsubstituted or substituted with one to three substituents independently selected from: (a) halogen, (b) aryl, (c) C.sub.1-8 alkyl, (d) C.sub.3-8 cycloalkyl, (e) C.sub.3-8 cycloheteroalkyl, (f) amino, (g) C.sub.1-6 alkylamino, (h) (C.sub.1-6 alkyl).sub.2 amino, (i) aryl C.sub.0-6 alkylamino, (j) (aryl C.sub.0-6 alkyl).sub.2 amino, (k) C.sub.1-6 alkylthio, (l) aryl C.sub.0-6 alkylthio, (m) C.sub.1-6 alkylsulfinyl, (n) aryl C.sub.0-6 alkylsulfinyl, (o) C.sub.1-6 alkylsulfonyl, (p) aryl C.sub.0-6 alkylsulfonyl, (q) C.sub.1-6 alkoxy, (r) aryl C.sub.0-6 alkoxy, (s) hydroxycarbonyl, (t) C.sub.1-6 alkoxycarbonyl, (u) aryl C.sub.0-6 alkoxycarbonyl, (v) hydroxycarbonyl C.sub.1-6 alkyloxy, (w) hydroxy, (x) cyano, (y) nitro, (z) perfluoroC.sub.1-4 alkyl, (aa) perfluoroC.sub.1-4 alkoxy, (bb) oxo, (cc) C.sub.1-6 alkylcarbonyloxy, (dd), aryl C.sub.0-6 alkylcarbonyloxy, (ee) alkyl C.sub.1-6 carbonylamino, (ff) aryl C.sub.0-6 alkylcarbonylamino, (gg) C.sub.1-6 alkylsulfonylamino, (hh) aryl C.sub.0-6 alkylsulfonylamino, (ii) C.sub.1-6 alkoxycarbonylamino, (j) aryl C.sub.0-6 alkoxycarbonylamino, (kk) C.sub.1-6 alkylaminocarbonylamino, (ll) aryl C.sub.0-6 alkylaminocarbonylamino, (mm) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (nn) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (oo) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (pp) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, and (qq) spiro-C.sub.3-8 cycloalkyl; (5) C.sub.3-8 cycloalkyl, either unsubstituted or substituted with one to 3 substituents selected from: (a) halogen, (b) aryl, (c) C.sub.1-8 alkyl, (d) C.sub.3-8 cycloalkyl, (e) C.sub.3-8 cycloheteroalkyl, (f) aryl C.sub.1-6 alkyl, (g) amino C.sub.0-6 alkyl, (h) C.sub.1-6 alkylamino C.sub.0-6 alkyl, (i) (C.sub.1-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (j) aryl C.sub.0-6 alkylamino C.sub.0-6 alkyl, (k) (aryl C.sub.0-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (l) C.sub.1-6 alkylthio, (m) aryl C.sub.0-6 alkylthio, (n) C.sub.1-6 alkylsulfinyl, (o) aryl C.sub.0-6 alkylsulfinyl, (p) C.sub.1-6 alkylsulfonyl, (q) aryl C.sub.0-6 alkylsulfonyl, (r) C.sub.1-6 alkoxy C.sub.0-6 alkyl, (s) aryl C.sub.0-6 alkoxy C.sub.0-6 alkyl, (t) hydroxycarbonyl C.sub.0-6 alkyl, (u) C.sub.1-6 alkoxycarbonyl C.sub.0-6 alkyl, (v) aryl C.sub.0-6 alkoxycarbonyl C.sub.0-6 alkyl, (w) hydroxycarbonyl C.sub.1-6 alkyloxy, (x) hydroxy C.sub.0-6 alkyl, (y) cyano, (z) nitro, (aa) perfluoroC.sub.1-4 alkyl, (bb) perfluoroC.sub.1-4 alkoxy, (cc) oxo, (dd) C.sub.1-6 alkylcarbonyloxy, (ee) aryl C.sub.0-6 alkylcarbonyloxy, (ff) alkyl C.sub.1-6 carbonylamino, (gg) aryl C.sub.0-6 alkylcarbonylamino, (hh) C.sub.1-6 alkylsulfonylamino, (ii) aryl C.sub.0-6 alkylsulfonylamino, (jj) C.sub.1-6 alkoxycarbonylamino, (kk) aryl C.sub.0-6 alkoxycarbonylamino, (ll) C.sub.1-6 alkylaminocarbonylamino, (mm) aryl C.sub.0-6 alkylaminocarbonylamino, (nn) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (oo) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (pp) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (qq) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, (rr) C.sub.0-6 alkylcarbonyl C.sub.0-6 alkyl, and (ss) spiro-C.sub.3-8 cycloalkyl; (6) cycloheteroalkyl, unsubstituted or substituted with one to three substituents selected from: (a) halogen, (b) aryl, (c) C.sub.1-8 alkyl, (d) C.sub.3-8 cycloalkyl, (e) C.sub.3-8 cycloheteroalkyl, (f) aryl C.sub.1-6 alkyl, (g) amino C.sub.0-6 alkyl, (h) C.sub.1-6 alkylamino C.sub.0-6 alkyl, (i) (C.sub.1-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (j) aryl C.sub.0-6 alkylamino C.sub.0-6 alkyl, (k) (aryl C.sub.0-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (l) C.sub.1-6 alkylthio, (m) aryl C.sub.0-6 alkylthio, (n) C.sub.1-6 alkylsulfinyl, (o) aryl C.sub.0-6 alkylsulfinyl, (p) C.sub.1-6 alkylsulfonyl, (q) aryl C.sub.0-6 alkylsulfonyl, (r) C.sub.1-6 alkoxy C.sub.0-6 alkyl, (s) aryl C.sub.0-6 alkoxy C.sub.0-6 alkyl, (t) hydroxycarbonyl C.sub.0-6 alkyl, (u) C.sub.1-6 alkoxycarbonyl C.sub.0-6 alkyl, (v) aryl C.sub.0-6 alkoxycarbonyl C.sub.0-6 alkyl, (w) hydroxycarbonyl C.sub.1-6 alkyloxy, (x) hydroxy C.sub.0-6 alkyl, (y) cyano, (z) nitro, (aa) perfluoroC.sub.1-4 alkyl, (bb) perfluoroC.sub.1-4 alkoxy, (cc) oxo, (dd) C.sub.1-6 alkylcarbonyloxy, (ee) aryl C.sub.0-6 alkylcarbonyloxy, (ff) alkyl C.sub.1-6 carbonylamino, (gg) aryl C.sub.0-6 alkylcarbonylamino, (hh) C.sub.1-6 alkylsulfonylamino, (ii) aryl C.sub.0-6 alkylsulfonylamino, (j) C.sub.1-6 alkoxycarbonylamino, (kk) aryl C.sub.0-6 alkoxycarbonylamino, (ll) C.sub.1-6 alkylaminocarbonylamino, (mm) aryl C.sub.0-6 alkylaminocarbonylamino, (nn) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (oo) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (pp) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (qq) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, and (rr) C.sub.0-6 alkylcarbonyl C.sub.0-6 alkyl, and (ss) spiro C.sub.3-8 cycloalkyl provided that any heteroatom substituent is bonded to a carbon atom in the cycloheteroalkyl ring; R.sup.3 is selected from H and C.sub.1-8 alkyl, or R.sup.2 and R.sup.3, together with the nitrogen atom to which they are attached, form a 5- to 7-membered heterocyclic ring, optionally containing one or two additional heteroatoms selected from N, S, and O, optionally having one or more degrees of unsaturation, optionally fused to a 6-membered heteroaromatic or aromatic ring, either unsubstituted or substituted with one to three substituents selected from: (1) halogen, (2) aryl, (3) C.sub.1-8 alkyl, (4) C.sub.3-8 cycloalkyl, (5) C.sub.3-8 cycloheteroalkyl, (6) aryl C.sub.1-6 alkyl, (7) amino C.sub.0-6 alkyl, (8) C.sub.1-6 alkylamino C.sub.0-6 alkyl, (9) (C.sub.1-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (10) aryl C.sub.0-6 alkylamino C.sub.0-6 alkyl, (11) (aryl C.sub.0-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (12) C.sub.1-6 alkylthio, (13) aryl C.sub.0-6 alkylthio, (14) C.sub.1-6 alkylsulfinyl, (15) aryl C.sub.0-6 alkylsulfinyl, (16) C.sub.1-6 alkylsulfonyl, (17) aryl C.sub.0-6 alkylsulfonyl, (18) C.sub.1-6 alkoxy C.sub.0-6 alkyl, (19) aryl C.sub.0-6 alkoxy C.sub.0-6 alkyl, (20) hydroxycarbonyl C.sub.0-6 alkyl, (21) C.sub.1-6 alkoxycarbonyl C.sub.0-6 alkyl, (22) aryl C.sub.0-6 alkoxycarbonyl C.sub.0-6 alkyl, (23) hydroxycarbonyl C.sub.1-6 alkyloxy, (24) hydroxy C.sub.0-6 alkyl, (25) cyano, (26) nitro, (27) perfluoroC.sub.1-4 alkyl, (28) perfluoroC.sub.1-4 alkoxy, (29) oxo, (30) C.sub.1-6 alkylcarbonyloxy, (31) aryl C.sub.0-6 alkylcarbonyloxy, (32) C.sub.1-6 alkyl carbonylamino, (33) aryl C.sub.0-6 alkylcarbonylamino, (34) C.sub.1-6 alkylsulfonylamino, (35) aryl C.sub.0-6 alkylsulfonylamino, (36) C.sub.1-6 alkoxycarbonylamino, (37) aryl C.sub.0-6 alkoxycarbonylamino, (38) C.sub.1-6 alkylaminocarbonylamino, (39) aryl C.sub.0-6 alkylaminocarbonylamino, (40) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (41) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (42) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, (43) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy, and (44) spiro-C.sub.3-8 cycloalkyl provided that any heteroatom substituent is bonded to a carbon atom in the heterocyclic ring; R.sup.4 and R.sup.5 are each independently selected from (1) hydrogen, (2) halogen, (3) aryl, (4) C.sub.1-8 alkyl, (5) C.sub.3-8 cycloalkyl, (6) C.sub.3-8 cycloheteroalkyl, (7) aryl C.sub.1-6 alkyl, (8) amino C.sub.0-6 alkyl, (9) C.sub.1-6 alkylamino C.sub.0-6 alkyl, (10) (C.sub.1-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (11) aryl C.sub.0-6 alkylamino C.sub.0-6 alkyl, (12) (aryl C.sub.0-6 alkyl).sub.2 amino C.sub.0-6 alkyl, (13) C.sub.1-6 alkylthio, (14) aryl C.sub.0-6 alkylthio, (15) C.sub.1-6 alkylsulfinyl, (16) aryl C.sub.0-6 alkylsulfinyl, (17) C.sub.1-6 alkylsulfonyl, (18) aryl C.sub.0-6 alkylsulfonyl, (19) C.sub.1-6 alkoxy C.sub.0-6 alkyl, (20) aryl C.sub.0-6 alkoxy C.sub.0-6 alkyl, (21) hydroxycarbonyl C.sub.0-6 alkyl, (22) C.sub.1-6 alkoxycarbonyl C.sub.0-6 alkyl, (23) aryl C.sub.0-6 alkoxycarbonyl C.sub.0-6 alkyl, (24) hydroxycarbonyl C.sub.1-6 alkyloxy, (25) hydroxy C.sub.0-6 alkyl, (26) cyano, (27) nitro, (28) perfluoroC.sub.1-4 alkyl, (29) perfluoroC.sub.1-4 alkoxy, (30) C.sub.0-6 alkylcarbonyl C.sub.0-6 alkyl, (31) C.sub.1-6 alkylcarbonyloxy, (32) aryl C.sub.0-6 alkylcarbonyloxy, (33) C.sub.1-6 alkyl carbonylamino, (34) aryl C.sub.0-6 alkylcarbonylamino, (35) C.sub.1-6 alkylsulfonylamino, (36) aryl C.sub.0-6 alkylsulfonylamino, (37) C.sub.1-6 alkoxycarbonylamino, (38) aryl C.sub.0-6 alkoxycarbonylamino, (39) C.sub.1-6 alkylaminocarbonylamino, (40) aryl C.sub.0-6 alkylaminocarbonylamino, (41) (C.sub.1-6 alkyl).sub.2 aminocarbonylamino, (42) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonylamino, (43) (C.sub.1-6 alkyl).sub.2 aminocarbonyloxy, and (44) (aryl C.sub.0-6 alkyl).sub.2 aminocarbonyloxy; or, R.sup.4 and R.sup.5 together form an oxo group or .dbd.CH--R.sup.6 or a spiro C.sub.3-7 cycloalkyl ring, unsubstituted or substituted with R.sup.6 ; R.sup.6 is selected from: (1) hydrogen, and (2) C.sub.1-4 alkyl; or a pharmaceutically acceptable salt thereof, and a bone-strengthening agent selected from: (a) estrogen or an estrogen derivative, alone or in combination with a progestin or progestin derivative, (b) a bisphosphonate, (c) an antiestrogen or a selective estrogen receptor modulator, (d) an osteoclast integrin inhibitor, (e) a cathepsin K inhibitor, (f) an HMG-CoA reductase inhibitor, (g) an osteoclast vacuolar ATPase inhibitor, (h) an antagonist of VEGF binding to osteoclast receptors, (i) a peroxisome proliferator-activated receptor .gamma., (j) calcitonin, (k) a calcium receptor antagonist, (l) parathyroid hormone, (m) a growth hormone secretagogue, (n) human growth hormone, (o) insulin-like growth factor, (p) a P-38 protein kinase inhibitor, (q) bone morphogenic protein, (r) an inhibitor of BMP antagonism, (s) a prostaglandin derivative, (t) vitamin D or vitamin D derivative, (u) vitamin K or vitamin K derivative, (v) ipriflavone, (w) fluoride salts, and (x) dietary calcium supplement. 22. A compound selected from: (1) N-(3-biphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (2) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (3) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (4) N-(3-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (5) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (6) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (7) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (8) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (9) N-(2-methyl-4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (10) N-(4-methoxy-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (11) N-(4-chloro-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (12) N-(2,4-dimethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (13) N-(3-bromo-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (14) N-(2,2,2-trifluoroethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (15) N-(2-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (16) N-(5-methyl-2-pyridinyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (17) N-(4-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (18) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (19) N-(4-bromo-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst- 1-ene-17.beta.-carboxamide, (20) N-(4-chloro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (21) N-(2,4-dichlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (22) N-(3-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (23) N-(4-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (24) N-(5-fluoro-2-pyridinyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (25) N-(5-chloro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (26) N-(2-phenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (27) N-(1-(3-phenylpropyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (28) N-(3-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (29) N-(2-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (30) N-(2-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (31) N-(3-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (32) N-(3-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (33) N-(4-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (34) N-(3-methoxybenzyl)-3-oxo-4-methyl4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (35) N-(2-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (36) N-(cyclohexylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (37) N-(3-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (38) N-(2-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (39) N-(3-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (40) N-(4-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (41) N-(3-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (42) N-(3-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (43) N-(4-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (44) N-(2-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (45) N-(4-methoxylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (46) N-((R)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (47) N-((S)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (48) N-(3-(1-pyrrolidin-2-one)-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst- 1-ene-17.beta.-carboxamide, (49) N-(2-furanylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (50) N-(1-naphthylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (51) N-(2-(4-imidazoylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (52) N-(2-(3-indolylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (53) N-(5-indolyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (54) N-((1,2-methylenedioxy)-4-benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1- ene-17.beta.-carboxamide, (55) N-(1,2-diphenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (56) N-(2-(1-hydroxy-1-phenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-en e-17.beta.-carboxamide, (57) N-(2-(2-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (58) N-(3-(1-imidazolyl)-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (59) N-(2-(2-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (60) N-(2-methoxyethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (61) N-(4-fluoro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (62) N-(2,4-difluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (63) N-(4-fluoro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (64) N-(4-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (65) N-(2-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (66) N-(3-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (67) N-(3,4-difluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (68) N-(4-dimethylaminobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (69) N-(2-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (70) N-(2-benzamidazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (71) N-(1-(4-phenylbutyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (72) N-(3,5-dimethoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (73) N-(2-(2-pyridinylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (74) N-(2-methyl-5-pyrazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (75) N-(2-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (76) N-(2-(2-thiophenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (77) N-(1-(1-naphthyl)-1(R)-ethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (78) N-(2-(3-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (79) N-(2-(2-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (80) N-(2-(4-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (81) N-(2-(4-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (82) N-(2-(3-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (83) N-(2-(3,4-methylenedioxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (84) N-(2-thiophenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (85) N-(2-(4-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (86) N-(2-aminobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (87) N-(2-(4-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (88) N-((1S, 2R) 2-hydroxy-1-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (89) N-(2-dimethylaminoethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (90) N-(phenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (91) N-(2-chlorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (92) N-(2-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (93) N-(2-trifluoromethoxyphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (94) N-(2-methoxyphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (95) N-(benzyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (96) N-(2-fluorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (97) N-(1,1,1-trifluoroethyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (98) N-(2-propyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxami de, (99) N-(2-biphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (100) N-(2-acetylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (101) N-(3-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (102) N-(2-pyridinyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (103) N-(3-pyridinyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carbox amide, (104) N-(2-methylsulfonylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (105) N-(2-methylsulfoxyphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (106) N-(phenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide , (107) N-(2-chlorophenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (108) N-(2-trifluoromethylphenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17. beta.-carboxamide, (109) N-(3-methylphenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (110) N-(2-methylphenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-car boxamide, (111) N-(2-cyanophenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carb oxamide, (112) N-(2-benzoylphenyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (113) N-(1,1,1-trifluoroethyl)-3-oxo-4-allyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (114) N-(phenyl)-3-oxo-4-benzyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (115) N-(2-chlorophenyl)-3-oxo-4-benzyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (116) N-(2-trifluoromethylphenyl)-3-oxo-4-benzyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (117) N-(phenyl)-3-oxo-4-phenyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamid e, (118) N-(2-trifluoromethylphenyl)-3-oxo-4-phenyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (119) N-(2-chlorophenyl)-3-oxo-4-phenyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (120) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (121) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (122) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.b eta.-carboxamide, (123) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (124) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (125) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (126) N-(phenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carboxamide, (127) N-(2-methoxyphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (128) N-(2-propyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carboxamide, (129) N-(2-biphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carboxamid e, (130) N-(benzyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carboxamide, (131) N-(2-fluorophenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.-carbox amide, (132) N-(1,1,1-trifluoroethyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.beta.- carboxamide, (133) N-(4-trifluoromethylphenyl)-3-oxo-4-ethyl-4-aza-5.alpha.-androstane-17.bet a.-carboxamide, (134) N-(1,1,1-trifluoroethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.be ta.-carboxamide, (135) N-(phenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-171-carboxamide, (136) N-(2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (137) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (138) N-(4-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (139) N-(2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (140) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (141) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (142) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (143) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (144) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (145) N-(2-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (146) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (147) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (148) N-(phenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.beta.-carbo xamide, (149) N-(2-trifluoromethylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-e ne-17.beta.-carboxamide, (150) N-(2-fluorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (151) N-(3-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (152) N-(3-trifluoromethylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-e ne-17.beta.-carboxamide, (153) N-(4-trifluoromethylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-e ne-17.beta.-carboxamide, (154) N-(2-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (155) N-(4-chlorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (156) N-(3-fluorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (157) N-(4-fluorophenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (158) N-(2-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (159) N-(3-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, (160) N-(4-methylphenyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene-17.bet a.-carboxamide, and (161) N-(1,1,1-trifluoroethyl)-3-oxo-4-cyclopropyl-4-aza-5.alpha.-androst-5-ene- 17.beta.-carboxamide, and pharmaceutically acceptable salts thereof. 23. The compound according to claim 21, selected from: (1) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (2) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (3) N-(3-chlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (4) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (5) N-(4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (6) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (7) N-(4-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (8) N-(2-methyl-4-trifluoromethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (9) N-(4-methoxy-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (10) (N-(4-chloro-3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (11) (N-(2,4-dimethoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (12) (N-(3-bromo-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (13) (N-(2,2,2-trifluoroethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (14) (N-(2-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (15) (N-(5-methyl-2-pyridinyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (16) (N-(4-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (17) (N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (18) (N-(4-bromo-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (19) (N-(4-chloro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-andros t-1-ene-17.beta.-carboxamide, (20) (N-(2,4-dichlorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (21) (N-(3-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (22) (N-(4-cyanophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (23) (N-(5-chloro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (24) (N-(2-phenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (25) (N-(1-(3-phenylpropyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (26) (N-(2-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (27) (N-(2-biphenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (28) (N-(3-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (29) (N-(4-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (30) (N-(3-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (31) (N-(2-methoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (32) (N-(cyclohexylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (33) (N-(3-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (34) (N-(2-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (35) (N-(3-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (36) (N-(4-methylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (37) (N-(3-trifluoromethylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (38) N-(3-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (39) N-(4-fluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (40) N-(2-chlorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-ca rboxamide, (41) N-(4-methoxylbenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (42) N-((R)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (43) N-((S)-2-phenyl-1-propyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (44) N-(2-furanylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (45) N-(1-naphthylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (46) N-(2-(3-indolylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (47) N-(5-indolyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (48) N-((1,2-methylenedioxy)-4-benzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1- ene-17.beta.-carboxamide, (49) N-(1,2-diphenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (50) N-(2-(2-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (51) N-(2-(2-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (52) N-(4-fluoro-2-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst -1-ene-17.beta.-carboxamide, (53) N-(2,4-difluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (54) N-(4-fluoro-2-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (55) N-(2-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (56) N-(3-phenoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-c arboxamide, (57) N-(3,4-difluorobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (58) N-(4-dimethylaminobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (59) N-(2-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxa mide, (60) N-(2-benzamidazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.b eta.-carboxamide, (61) N-(3,5-dimethoxybenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (62) N-(2-(2-pyridinylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.bet a.-carboxamide, (63) N-(2-methyl-5-pyrazolemethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene- 17.beta.-carboxamide, (64) N-(2-pyridinylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (65) N-(2-(2-thiophenylethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.be ta.-carboxamide, (66) N-(2-(3-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (67) N-(2-(2-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (68) N-(2-(4-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (69) N-(2-(4-nitrobenzyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (70) N-(2-(3-fluorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (71) N-(2-(3,4-methylenedioxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-andros t 1-ene-17.beta.-carboxamide, (72) N-(2-thiophenylmethyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta .-carboxamide, (73) N-(2-(4-methoxyphenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-1 7.beta.-carboxamide, (74) N-(2-(2-aminobenzyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta. -carboxamide, (75) N-(2-(4-chlorophenylethyl))-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17 .beta.-carboxamide, (76) N-((1S, 2R) 2-hydroxy-1-indanyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-1-ene-17.beta.- carboxamide, (77) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (78) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (79) N-(4-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carbo xamide, (80) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androstane-17.beta.-carb oxamide, (81) N-(3-trifluoromethylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17 .beta.-carboxamide, (82) N-(3-methylphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (83) N-(2-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (84) N-(3-fluorophenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-ca rboxamide, (85) N-(3-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, (86) N-(4-methoxyphenyl)-3-oxo-4-methyl-4-aza-5.alpha.-androst-5-ene-17.beta.-c arboxamide, and pharmaceutically acceptable salts thereof. 24. A composition comprising a compound according to claim 21 and a pharmaceutically acceptable carrier. 25. A composition comprising a compound according to claim 22 and a pharmaceutically acceptable carrier.

Details for Patent 6,645,974

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015		2021-07-31