You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: April 25, 2024

Claims for Patent: 6,610,830

✉ Email this page to a colleague

« Back to Dashboard

Summary for Patent: 6,610,830

Title:	Microbial production of mature human leukocyte interferons
Abstract:	Disclosed herein are methods and means of microbially producing, via recombinant DNA technology, mature human leukocyte interferons, useful in the treatment of viral and neoplastic diseases.
Inventor(s):	Goeddel; David V. (Burlingame, CA), Pestka; Sidney (North Caldwell, NJ)
Assignee:	Hoffman-La Roche Inc. (Nutley, NJ) Genentech, Inc. (South San Francisco, CA)
Application Number:	06/256,204
Patent Claims:	1. A polypeptide of about 165-166 amino acids comprising the amino acid sequence of a mature human leukocyte interferon microbially produced and unaccompanied by any corresponding presequence or portion thereof. 2. The polypeptide according to claim 1, wherein the amino acid sequence is SEQ ID NO:45 or SEQ ID NO:71. 3. The polypeptide according to claim 1, wherein the amino acid sequence is SEQ ID NO:46 or SEQ ID NO:72. 4. The polypeptide according to claim 1, wherein the amino acid sequence is SEQ ID NO:47 or SEQ ID NO:73. 5. The polypeptide according to claim 1, wherein the amino acid sequence is SEQ ID NO:48 or SEQ ID NO:74. 6. The polypeptide according to claim 1, wherein the amino acid sequence is SEQ ID NO:49 or SEQ ID NO:75. 7. The polypeptide according to claim 1, wherein the amino acid sequence is SEQ ID NO:50 or SEQ ID NO:76. 8. The polypeptide according to claim 1, wherein the amino acid sequence is SEQ ID NO:51 or SEQ ID NO:77. 9. The polypeptide according to claim 1, wherein the amino acid sequence is SEQ ID NO:53 or SEQ ID NO:78. 10. The polypeptide according to claim 1, wherein the amino acid sequence is SEQ ID NO:55 or SEQ ID NO:79. 11. The polypeptide according to claim 1, wherein the amino acid sequence is SEQ ID NO:54 or SEQ ID NO:80. 12. The polypeptide according to claim 1, wherein the amino acid sequence is SEQ ID NO:55 or SEQ ID NO:81. 13. The polypeptide according to claim 1, wherein the amino acid sequence is SEQ ID NO:56 or SEQ ID NO:82. 14. The polypeptide according to claim 1, wherein the amino acid sequence is SEQ ID NO:57 or SEQ ID NO:83. 15. The polypeptide according to claim 1, wherein the amino acid sequence is SEQ ID NO:58 or SEQ ID NO:84. 16. The polypeptide according to claim 1, wherein the amino acid sequence is SEQ ID NO:59 or SEQ ID NO:85. 17. A composition comprising a polypeptide of about 165-166 amino acids comprising the amino acid sequence of a mature human leukocyte interferon unaccompanied by any corresponding presequence or portion thereof, wherein the composition is free of other human proteins. 18. The composition according to claim 17, wherein the amino acid sequence is SEQ ID NO:45 or SEQ ID NO:71. 19. The composition according to claim 17, wherein the amino acid sequence is SEQ ID NO:46 or SEQ ID NO:72. 20. The composition according to claim 17, wherein the amino acid sequence is SEQ ID NO:47 or SEQ ID NO:73. 21. The composition according to claim 17, wherein the amino acid sequence is SEQ ID NO:48 or SEQ ID NO:74. 22. The composition according to claim 17, wherein the amino acid sequence is SEQ ID NO:49 or SEQ ID NO:75. 23. The composition according to claim 17, wherein the amino acid sequence is SEQ ID NO:50 or SEQ ID NO:76. 24. The composition according to claim 17, wherein the amino acid sequence is SEQ ID NO:51 or SEQ ID NO:77. 25. The composition according to claim 17, wherein the amino acid sequence is SEQ ID NO:52 or SEQ ID NO:78. 26. The composition according to claim 17, wherein the amino acid sequence is SEQ ID NO:53 or SEQ ID NO:79. 27. The composition according to claim 17, wherein the amino acid sequence is SEQ ID NO:54 or SEQ ID NO:80. 28. The composition according to claim 17, wherein the amino acid sequence is SEQ ID NO:55 or SEQ ID NO:81. 29. The composition according to claim 17, wherein the amino acid sequence is SEQ ID NO:56 or SEQ ID NO:82. 30. The composition according to claim 17, wherein the amino acid sequence is SEQ ID NO:57 or SEQ ID NO:83. 31. The composition according to claim 17, wherein the amino acid sequence is SEQ ID NO:58 or SEQ ID NO:84. 32. The composition according to claim 17, wherein the amino acid sequence is SEQ ID NO:59 or SEQ ID NO:85. 33. The polypeptide according to claim 1, wherein the amino acid sequence includes the amino acids specified and positioned as indicated in the sequence "All" of FIG. 4. 34. The polypeptide according to any one of claims 1-16, and 33, wherein the amino-terminal amino acid is methionine. 35. A composition comprising a polypeptide according to any one of claims 1-16 and 33 and soluble microbial proteins. 36. A composition comprising a polypeptide according to any one of claims 1-16 and 33 and soluble bacterial proteins. 37. A composition comprising a polypeptide according to any one of claims 1-16 and 33, wherein the composition is free of other animal proteins. 38. A composition comprising a polypeptide according to any one of claims 1-16 and 33, wherein the composition is free of other mammalian proteins. 39. A composition comprising a polypeptide according to any one of claims 1-16 and 33, wherein the composition is free of other human proteins. 40. The polypeptide according to any one of claims 1-16 and 33, wherein the polypeptide is bacterially produced. 41. The composition according to claim 17, wherein the amino acid sequence includes the amino acids specified and positioned as indicated in the sequence "All" of FIG. 4. 42. The composition according to any one of claims 17-32 and 41, wherein the amino-terminal amino acid of the polypeptide is methionine. 43. The composition according to any one of claims 17-32 and 41, further comprising soluble microbial proteins. 44. The composition according to any one of claims 17-32 and 41, further comprising soluble bacterial proteins. 45. The composition according to any one of claims 17-32 and 41, wherein the composition is free of other animal proteins. 46. The composition according to any one of claims 17-32 and 41, wherein the composition is free of other mammalian proteins.

Details for Patent 6,610,830

Subscribe to access the full database, or Try a Trial
Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2020-08-26
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2020-08-26
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2020-08-26
Merck Sharp & Dohme Corp.	PEGINTRON	peginterferon alfa-2b	Injection	103949	01/19/2001	⤷ Try a Trial	2020-08-26
Merck Sharp & Dohme Corp.	SYLATRON	peginterferon alfa-2b	For Injection	103949	03/29/2011	⤷ Try a Trial	2020-08-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 6,610,830

Subscribe to access the full database, or Try a Trial
Country	Patent Number	Estimated Expiration
Argentina	242833	⤷ Try a Trial
Austria	380272	⤷ Try a Trial
Austria	394207	⤷ Try a Trial
Austria	394208	⤷ Try a Trial
Austria	A170285	⤷ Try a Trial
Austria	A170385	⤷ Try a Trial
Austria	A290981	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.