Claims for Patent: 6,495,738

Summary for Patent: 6,495,738

Title:	Modification of fatty acid composition in plants by expression of a fungal acyl-CoA desaturase
Abstract:	Genes-encoding a delta-9 CoA desaturase from Aspergillus nidulans have been isolated. The proteins encoded by genes, when expressed in a plant, can alter the saturate levels of the oil.
Inventor(s):	Folkerts; Otto (Guilford, CT), Merlo; Donald J. (Carmel, IN)
Assignee:	Dow AgroSciences LLC (Indianapolis, IN)
Application Number:	09/280,428
Patent Claims:	1. An isolated nucleic acid having a nucleotide sequence of SEQ ID NO:5 or SEQ ID NO:12. 2. An isolated nucleic acid encoding the protein of SEQ ID NO:6. 3. A DNA construct comprising, in the 5' to 3' direction: a promoter regulatory element, a nucleic acid fragment encoding a palmitoyl-CoA .DELTA.-9 desaturase from Aspergillus, and a transcriptional terminator sequence, wherein either said promoter regulatory element or said transcription termination sequence is not naturally associated with said nucleic acid fragment. 4. The construct of claim 3 wherein said promoter regulatory element is selected from the group consisting of ubiquitin promoter, maize globulin promoter, maize streak virus leader sequence, 35s promoter, 35T promoter, the first intron of maize alcohol dehydrogenase and beta-phaseolin promoter. 5. The construct of claim 3 wherein said nucleic acid fragment is selected from the group consisting of SEQ ID NO:5 and SEQ ID NO:12. 6. A plant cell stably incorporating into its genome the nucleic acid construct of claim 3. 7. A plant cell stably incorporating 4 into its genome the nucleic acid construct of claim 5. 8. A plant cell of claim 6 wherein said promoter regulatory element is selected from the group consisting of ubiquitin promoter, maize globulin promoter, maize streak virus enhancer region, 35s promoter, doubly enhanced 35s promoter, the first intron of maize alcohol dehydrogenase and beta-phaseolin. 9. A plant cell of claim 6 wherein said plant cell is selected from the group consisting of soybean, a Brassicaceae species, canola, rape, sunflower, flax, safflower, coconut, palm, olive, peanut, cotton, castor bean, coriander, a Crambe species, a Cuphea species, a Euphorbia species, a Oenothera species, jojoba, a Lesquerella species, marigold, a Limnanthes species, a Vernonia species, Sinapis alba, cocoa, tobacco, and maize. 10. A plant cell of claim 6 wherein said cell is a seed embryo cell. 11. A transgenic plant produced from a plant cell of claim 6. 12. Seed and progeny thereof which stably incorporate the nucleic acid construct of claim 4, said seed and progeny produced from a transgenic plant of claim 11. 13. A method of producing a plant oil having altered levels of fatty acids comprising: growing a plant cell having integrated into its genome a construct comprising, in the 5' to 3' direction, a promoter regulatory element functional in a plant cell; a nucleic acid fragment that encodes a delta-9 CoA desaturase isolated from Aspergillus, the delta-9 CoA desaturase selected from the group consisting of SEQ ID NO:6, SEQ ID NO:6 with conservative amino acid substitutions, and derivatives of any thereof; and a transcriptional terminator sequence.

Details for Patent 6,495,738

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986		2018-03-30
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132			2018-03-30
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132			2018-03-30
Aimmune Therapeutics, Inc.	PALFORZIA	peanut (arachis hypogaea) allergen powder	Powder	125696	01/31/2020		2018-03-30