Claims for Patent: 6,432,704

Summary for Patent: 6,432,704

Title:	Method and reagent for inhibiting herpes simplex virus replication
Abstract:	An enzymatic RNA molecule which specifically cleaves a herpes simplex virus mRNA molecule.
Inventor(s):	Draper; Kenneth G. (Boulder, CO)
Assignee:	Ribozyme Pharmaceuticals, Inc. (Boulder, CO)
Application Number:	09/340,861
Patent Claims:	1. An enzymatic RNA molecule which cleaves RNA encoded by a herpes simplex virus (HSV) in the ICP4 gene. 2. The enzymatic RNA molecule of claim 1 which cleaves a sequence selected from the group consisting of SEQ ID NO: 1-43. 3. The enzymatic RNA molecule of claim 2 which cleaves a sequence comprising SEQ ID NO: 1 or SEQ ID NO: 8. 4. The enzymatic RNA molecule of claim 1, wherein said enzymatic RNA molecule is selected from the group consisting of enzymatic RNA molecules that cleave the ICP4 gene at residue 66, 200, 309, 864, 888, 870, 894 or 3559. 5. The enzymatic RNA molecule of claim 1, wherein said RNA molecule is in a hammerhead motif. 6. The enzymatic RNA molecule of claim 1, wherein said RNA molecule is in a hairpin, hepatitis Delta virus, group I intron, or RNAse P RNA motif. 7. An isolated mammalian cell comprising an enzymatic molecule of claim 1. 8. An isolated mammalian cell comprising an enzymatic molecule of claim 4. 9. The cell of claim 7 or claim 8, wherein said cell is a human cell. 10. A vector comprising nucleic acid encoding the enzymatic RNA molecule of claim 1. 11. A vector comprising nucleic acid encoding the enzymatic RNA molecule of claim 4.

Details for Patent 6,432,704

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986		2012-05-14
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132			2012-05-14
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132			2012-05-14