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Last Updated: October 16, 2019

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Claims for Patent: 6,428,805

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Summary for Patent: 6,428,805
Title: Powdery nasal compositions
Abstract:A powdery nasal composition comprising a drug and colloidal cellulose is provided. The composition is a nasal composition providing a superior absorption activity for the drug.
Inventor(s): Dohi; Masahiko (Hino, JP), Uejima; Yasuhide (Hino, JP), Fujii; Takao (Hino, JP)
Assignee: Teijin Limited (Osaka, JP)
Application Number:09/530,203
Patent Claims:1. A powdery nasal composition comprising a drug and colloidal cellulose, wherein said colloidal cellulose is obtained by spray-drying crystalline cellulose and one or more viscosity-increasing polymers selected from the group consisting of carboxymethylcellulose, a sodium salt of carboxymethylcellulose, a calcium salt of carboxymethylcellulose, xantha gum, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, and acrylic acid starch.

2. The powdery nasal composition according to claim 1 wherein said drug is a nonpeptidyl and nonproteinaceous drug or a peptidyl and proteinaceous drug.

3. The powdery nasal composition according to claim 2, wherein said nonpeptidyl and nonproteinaceous drug is one or more of the drugs selected from the group consisting of anti-inflammatory steroids or non-steroidal anti-inflammatory drugs, analgesic anti-inflammatory drugs, antitussive expectorant drugs, anti-histamine drugs, anti-allergic drugs, anti-emetic drugs, hypnotic drugs, vitamins, sex steroid hormones, anti-cancer drugs, anti-arrhythmic drugs, anti-hypertensive drugs, anti-anxiety drugs, psychomimetics, anti-ulcer drugs, cardiac stimulants, analgesics, bronchodilators, anti-obesity drugs, platelet aggregation suppressive drugs, anti-diabetic drugs, muscle relaxants, anti-migraine drugs, and anti-rheumatic drugs.

4. The powdery nasal composition according to claim 2, wherein said peptidyl and proteinaceous drug is one or more of the drugs selected from the group consisting of luteinizing hormone-releasing hormones, growth hormone-releasing factors, somatostatin derivatives, vasopressins, oxytocins, hirudin derivatives, enkephalins, adrenocorticotrophic hormone derivatives, bradykinin derivatives, calcitonins, insulins, glucagon derivatives, growth hormones, growth hormone-releasing hormones, luteinizing hormones, insulin growth hormones, calcitonin gene-related peptides, atrial natriuretic peptide derivatives, interferons, erythropoietins, granulocyte colony-stimulating factor, macrophage forming stimulating factor, parathyroid hormones, parathyroid hormone-releasing hormone, prolactin, thyroid stimulating hormone-releasing hormone, and angiotensins.

5. A powdery nasal composition comprising a drug and colloidal cellulose obtained by spray-drying crystalline cellulose and one or more viscosity-increasing polymers selected from the group consisting of carboxymethylcellulose, a sodium salt of carboxymethylcellulose, a calcium salt of carboxymethylcellulose, xanthan gum, hydroxypropyl Cellulose, hydroxypropyl nethyl cellulose, and acrylic acid starch, wherein said colloidal cellulose is one or more colloidal celluloses selected front the group consisting of Avicel RC-581, Avicel RC-591, and Avicel CL-611.

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Foriegn Application Priority Data
Foreign Country Foreign Patent Number Foreign Patent Date
Japan10-240242Aug 26, 1998
PCT Information
PCT FiledAugust 24, 1999PCT Application Number:PCT/JP99/04560
PCT Publication Date:March 09, 2000PCT Publication Number:WO00/12136

Details for Patent 6,428,805

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 001 2015-01-23   Request a Trial Teijin Limited (Osaka, JP) 2018-08-26 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 002 2015-01-23   Request a Trial Teijin Limited (Osaka, JP) 2018-08-26 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 003 2015-01-23   Request a Trial Teijin Limited (Osaka, JP) 2018-08-26 RX Orphan search
Nps Pharms Inc NATPARA parathyroid hormone INJECTABLE;INJECTION 125511 004 2015-01-23   Request a Trial Teijin Limited (Osaka, JP) 2018-08-26 RX Orphan search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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