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Last Updated: April 26, 2024

Claims for Patent: 6,271,025

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Summary for Patent: 6,271,025

Title:	Modified factor VIII cDNA
Abstract:	A modified Factor VIII cDNA is described comprising deletion of the B-domain and insertion of at least one truncated Factor IX intron 1 in the Factor VIII cDNA. The modified Factor VIII cDNA may be used for the production of a high yield of Factor VIII in vitro. The modified Factor VIII cDNA may be incorporated into a vector for gene therapy.
Inventor(s):	Negrier; Claude (Irigny, FR), Plantier; Jean Luc (Grigny, FR)
Assignee:	Aventis Behring GmbH (Marburg, DE)
Application Number:	09/526,935
Patent Claims:	1. A modified Factor VIII cDNA comprising a deletion of the B-domain and insertion of the truncated Factor IX intron 1 (SEQ ID NO: 9) in one or more splice sites of the Factor VIII cDNA, wherein said cDNA encodes a polypeptide having Factor VIII activity. 2. A modified Factor VIII cDNA comprising a replacement of the B-domain with nucleotides encoding four arginines and insertion of the truncated Factor IX intron 1 (SEQ ID NO: 9) in one or more splice sites of the Factor VIII cDNA, wherein said cDNA encodes a polypeptide having Factor VIII activity. 3. The modified Factor VIII cDNA as claimed in claim 1, wherein at least one insertion site of the truncated Factor IX intron 1 is chosen from Factor VIII intron 1 splice site, Factor VIII intron 12 splice site, and Factor VIII intron 13 splice site. 4. The modified Factor VIII cDNA as claimed in claim 2, wherein at least one insertion site of the truncated Factor IX intron 1 is chosen from Factor VIII intron 1 splice site, Factor VIII intron 12 splice site, and Factor VIII intron 13 splice site. 5. A vector comprising the modified Factor VIII cDNA of claim 1. 6. A vector comprising the modified Factor VIII cDNA of claim 2.

Details for Patent 6,271,025

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2019-03-17
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2019-03-17
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2019-03-17
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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