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Last Updated: December 16, 2025

Claims for Patent: 6,060,447

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Summary for Patent: 6,060,447

Title:	Protein complexes having Factor VIII:C activity and production thereof
Abstract:	Recombinant protein complexes having human Factor VIII:C activity are expressed in a eukaryotic host cell by transforming the host cell with first and second expression cassettes encoding a first polypeptide substantially homologous to human Factor VIII:C A domain and a second polypeptide substantially homologous to human Factor VIII:C C domain, respectively. In the present invention, the first polypeptide may be extended having at its C-terminal a human Factor VIII:C B domain N-terminal peptide, a polypeptide spacer of 3-40 amino acids, and a human Factor VIII:C B domain C-terminal peptide. Expression of the second polypeptide is improved by employing an alpha 1-antitrypsin signal sequence.
Inventor(s):	Barbara Chapman, Rae Lyn Burke, Mirella Ezban Rasmussen, Jan Moller Mikkelson
Assignee:	GSK Vaccines SRL , Novartis Vaccines and Diagnostics Inc
Application Number:	US08/441,935

Details for Patent 6,060,447

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bayer Healthcare Llc	HELIXATE FS, KOGENATE, KOGENATE FS	antihemophilic factor (recombinant)	For Injection	103332	August 20, 2002	⤷ Get Started Free	2017-05-09
Bayer Healthcare Llc	HELIXATE FS, KOGENATE, KOGENATE FS	antihemophilic factor (recombinant)	For Injection	103332	June 07, 2007	⤷ Get Started Free	2017-05-09
Bayer Healthcare Llc	HELIXATE FS, KOGENATE, KOGENATE FS	antihemophilic factor (recombinant)	For Injection	103332	July 31, 2009	⤷ Get Started Free	2017-05-09
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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