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Last Updated: January 26, 2022

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Claims for Patent: 6,015,567

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Summary for Patent: 6,015,567
Title: HER2 extracellular domain
Abstract:A method of treating a human patient via active immunotherapy comprising administrating an effective amount of extracellular portion of human HER2 receptor to the patient wherein the method provokes a cell-mediated immune response to HER2 receptor in the patient treated therewith.
Inventor(s): Hudziak; Robert Michael (San Bruno, CA), Shepard; H. Michael (San Francisco, CA), Ullrich; Axel (Martinsried, DE)
Assignee: Genentech, Inc. (South San Franisco, CA)
Application Number:08/422,108
Patent Claims:1. A method of treating a human patient via active specific immunotherapy comprising administering an effective amount of an extracellular portion of the human HER2 receptor to the patient, wherein the method provokes a cell-mediated immune response to the HER2 receptor in the patient treated therewith.

2. The method of claim 1 wherein the patient has, or is at risk of acquiring, cancer.

3. The method of claim 2 wherein cells from a tissue of the patient have increased numbers of the HER2 receptor residing on the surfaces thereof, relative to normal cells of the same tissue type.

4. The method of claim 3 wherein the tissue is mammary gland tissue.

5. The method of claim 4 wherein the patient is a woman.

6. The method of claim 3 wherein the tissue is salivary gland tissue.

7. The method of claim 3 wherein the tissue is gastric tissue.

8. The method of claim 3 wherein the tissue is colon tissue.

9. The method of claim 1 which further comprises administering an adjuvant to the patient.

10. The method of claim 9 wherein the adjuvant is selected from the group consisting of alum, Bacillus calmette-Guerin (BCG), a BCG cell wall derivative, Corynebacterium parvum, interferon gamma, interleukin 1, interleukin 2 and interleukin 6.

11. The method of claim 1 which elicits both a humoral and cell-mediated response in the patient.

12. The method of claim 1 wherein the extracellular portion is fused to a heterologous molecule.

13. The method of claim 12 wherein the heterologous molecule comprises the Fc-portion of an immunoglobulin molecule.

14. A method of provoking a humoral and cell-mediated immune response to the HER2 receptor in a human patient comprising administering an effective amount of an extracellular portion of the human HER2 receptor to the patient.

15. The method of claim 14 wherein the patient has, or is at risk of acquiring, cancer.

16. The method of claim 14 wherein cells from a tissue of the patient have increased numbers of the HER2 receptor residing on the surfaces thereof, relative to normal cells of the same tissue type.

17. The method of claim 16 wherein the tissue is mammary gland tissue.

18. The method of claim 16 wherein the tissue is salivary gland tissue.

19. The method of claim 16 wherein the tissue is gastric tissue.

20. The method of claim 16 wherein the tissue is colon tissue.

21. The method of claim 14 which further comprises administering an adjuvant to the patient.

22. The method of claim 14 wherein the extracellular portion is fused to a heterologous molecule.

23. The method of claim 14 which induces a T-cell response to the HER2 receptor.

24. The method of claim 1 which induces a T-cell response to the HER2 receptor.

25. A method of treating a human patient via active specific immunotherapy comprising administering an effective amount of an isolated extracellular portion of the human HER2 receptor to the patient, wherein the method provokes a cell-mediated immune response to the HER2 receptor in the patient treated therewith.

26. A method of provoking a humoral and cell-mediated immune response to the HER2 receptor in a human patient comprising administering an effective amount of an isolated extracellular portion of the human HER2 receptor to the patient.

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