Claims for Patent: 6,004,568

Summary for Patent: 6,004,568

Title:	Cosmetic or pharmaceutical, particularly dermatological, composition containing a Bertholletia extract
Abstract:	The object of the invention is the use of a Bertholletia extract, particularly a Bertholletia excelsa extract, for the preparation of a cosmetic or pharmaceutical composition, particularly a dermatological composition. The Bertholletia extract promotes collagen synthesis or has activity against free radicals, for example to combat the effects of skin ageing, to prevent the formation of wrinkles or reduce their depth, or to promote firmer skin. It also has an activity for promoting the incorporation of vitamin C in the skin cells.
Inventor(s):	Bonte; Frederic (Orleans, FR), Dumas; Marc (Orleans, FR), Lavaud; Catherine (Tinqueux, FR), Massiot; Georges (Reims, FR)
Assignee:	LVMH Recherche (Nanterre, FR)
Application Number:	08/917,622
Patent Claims:	1. A cosmetic or pharmaceutical composition comprising as active ingredient a Bertholletia extract in a cosmetically or pharmaceutically effective amount, in a cosmetically or pharmaceutically acceptable excipient intended for topical use. 2. A composition according to claim 1, wherein said extract is extracted from Bertholletia excelsa. 3. A composition according to claim 1, wherein said Bertholletia extract is extracted from a part of Bertholletia selected from the group consisting of bark, nut, trunk bark and nut pericarp. 4. A composition according to claim 1, wherein said extract is obtained by extraction with a polar solvent. 5. A composition according to claim 4, wherein said polar solvent is selected from the group consisting of water, alcohols, chlorinated solvents, organic esters, and mixtures thereof. 6. A composition according to claim 4, wherein said polar solvent is selected from the group consisting of water, methanol, ethanol and mixtures thereof. 7. A composition according to claim 1, wherein said extract is enriched in saponins. 8. A composition according to claim 1, wherein said extract is present in an amount between 0.0001% and 1% by weight, based on the total weight of said composition. 9. A composition according to claim 1, further comprising an active substance selected from the group consisting of ascorbic acid, madecassic acid, asiatic acid, madecassoside, asiaticoside, alpha-1-proteinase inhibitors, collagenase inhibitors, elastase inhibitors, lysine, proline, 2-oxoglutarate, ginsenoside Ro, vitamin D, vitamin D derivatives, ecdysteroids and vitamin E. 10. A composition according to claim 1, further comprising vitamin C or a derivative thereof. 11. A method of treatment of the human body comprising the topical application to an external area of the human body of a cosmetic or pharmaceutical composition comprising a cosmetically or pharmaceutically effective amount of a Bertholletia extract. 12. A method according to claim 11, wherein said extract is extracted from Bertholletia excelsa. 13. A method according to claim 11, wherein said extract is present in said composition at a concentration comprised between 0.0001% and 1% by weight, based on the total weight of the final composition. 14. A method according to claim 11, wherein said method of treatment is selected from the group consisting of methods for stimulating the synthesis of collagen I, collagen IV, or collagen VII, methods for obtaining an anti-free radical activity, methods for improving skin healing as well as biochemical properties and surface appearance of the skin, methods for obtaining firmer skin, methods for combating the effects of skin ageing, methods for treating the diverse pathological conditions accompanied by a collagen deficiency, and methods for promoting the incorporation of vitamin C into the skin cells. 15. A method according to claim 11, wherein said treatment is selected from the group consisting of treatments against skin ageing, treatments against wrinkles, and treatments intended for reducing wrinkle depth. 16. A method according to claim 11, wherein said treatment is a treatment for treating pathological conditions associated with the deficiency of the epidermal-dermal junction. 17. A method according to claim 16, wherein said treatment is a treatment of epidermalysis bullosa. 18. A method according to claim 11, wherein said treatment is for treating pathological conditions associated with a deficiency of incorporation of vitamin C into the skin cells. 19. Medium for the culture of skin cells containing a Bertholletia extract in an amount sufficient for stimulating collagen synthesis by said cells or for promoting incorporation of vitamin C into said cells.

Details for Patent 6,004,568

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2016-08-22