Claims for Patent: 5,990,098

Summary for Patent: 5,990,098

Title:	Therapeutic use of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid and its salts
Abstract:	Use of 1-amino-3-N,N-dimethylamino)-propyliden-1,1-bisphosphonic acid of the structural formula: ##STR1## or of its monosodium or other pharmaceutically acceptable salt, as a biological carrier for bone active substances or for the preparation of a medicament for the diagnosis, prophylaxis and/or treatment of bone and/or mineral metabolism disorders.
Inventor(s):	Van Beek; Ermond R. (Leiden, NL), Lowik; Clemens W. G. M. (Leiden, NL), Papapoulos; Socrates (Leiden, NL), Labriola; Rafael (Pilar, AR), Vecchioli; Adriana (Pilar, AR)
Assignee:	Gador, S.A. (AR) University of Leiden (NL)
Application Number:	08/983,247
Patent Claims:	1. A bone-active composition comprising a bone-active substance and a biological carrier for said bone active substance, wherein said biological carrier is a 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid having the structural formula: ##STR7## or its monosodium or other pharmaceutically acceptable salt. 2. A composition according to claim 1, wherein said other bone-active substance is selected from the group consisting of cytokines, growths factors, prostaglandins, hormones, glycine or other amino acids or modified amino acids and cytostatic drugs. 3. A pharmaceutical composition for the diagnosis, prophylaxis and/or treatment of bone and/or mineral metabolism disorders, said composition comprising a bone active substance and a biological carrier for said bone-active substance, wherein said biological carrier is a 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid having the structural formula: ##STR8## or its monosodium or other pharmaceutically acceptable salt. 4. A composition according to claim 3 wherein said composition is for the diagnosis, prophylaxis and/or treatment of urolithiasis, ectopic calcifications, all forms of osteoporosis, all forms of arthritis and all forms of periodontal diseases. 5. The composition according to claim 1, comprising at least one calcium salt. 6. The composition according to claim 1, comprising vitamin D or derivatives thereof. 7. The composition according to claim 1, comprising at least one fluoride salt. 8. The composition according to claim 1, comprising at least one parathyroid hormone. 9. The composition according to claim 1, comprising at least one androgen. 10. The composition according to claim 1, comprising at least one estrogen. 11. A method for diagnosing prophylaxis, or treating bone and/or mineral metabolism disorders, said method comprising administering to a patient suffering from bone and/or mineral metabolism disorders an effective amount of a bone active substance and a biological carrier for said bone active substance, wherein said biological carrier is a 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid having the structural formula: ##STR9## or its monosodium or other pharmaceutically acceptable salt. 12. A method as in claim 11, wherein said diagnosis, prophylaxis and/or treatment is selected from the group consisting of urolithiasis, ectopic calcifications, all forms of osteoporosis, all forms of arthritis and all forms of periodontal diseases. 13. A method as in claim 11, further comprising the simultaneous or sequential administration of at least one calcium salt. 14. A method as in claim 11, further comprising the simultaneous or sequential administration of vitamin D or derivatives thereof. 15. A method as in claim 11, further comprising the simultaneous or sequential administration of at least one fluoride salt. 16. A method as in claim 11, further comprising the simultaneous or sequential administration of at least one parathyroid hormone. 17. A method as in claim 11, further comprising the simultaneous or sequential administration of at least one androgen. 18. A method as in claim 11, further comprising the simultaneous or sequential administration of at least one estrogen.

Details for Patent 5,990,098

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015		2015-07-10