Claims for Patent: 5,919,755

Summary for Patent: 5,919,755

Title:	Medical use of heme products
Abstract:	The invention is to a method for stimulating the production of fetal hemoglobin in a mammal having a hemoglobinopathy, comprising administering heme or a derivative thereof.
Inventor(s):	Kangasaho; Mauno (Turku, FI), Relander; Klaus (Turku, FI)
Assignee:	Leiras OY (FI)
Application Number:	08/875,440
Patent Claims:	1. A method for stimulating the production of fetal hemoglobin in a mammal having a hemoglobinopathy which comprises administering to a mammal in need thereof an effective amount of a heme or derivative thereof and a pharmaceutically acceptable carrier, wherein said derivative is selected from the group consisting hematin, hemin, an amino acid addition salt of heme, heme albumin, a biochemical precursor of heme, an amino acid addition salt of said precursor and a reversible complex of said precursor with albumin. 2. The method of claim 1 wherein said hemoglobinopathy is sickle cell anemia or .beta.-thalassemia. 3. The method of claim 1 wherein the heme derivative is heme reversibly bound to albumin or an amino acid addition salt of heme. 4. The method of claim 2 wherein the heme derivative is heme arginate. 5. The method of claim 1 which further comprises administering an inhibitor of heme catabolism, a cytostatic agent, a retinoid or other differentiation-inducing agent, a cytokine, a biological growth favor, an agent which induces production of fetal hemoglobin or a mixture thereof. 6. The method of claim 5 wherein the agent administered is an inhibitor of heme catabolism selected from the group consisting of tin and zinc mesoporphyrin.

Details for Patent 5,919,755

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	PANHEMATIN	hemin for injection	For Injection	101246	07/20/1983		2015-01-30