Claims for Patent: 5,866,552

Summary for Patent: 5,866,552

Title:	Method for expressing a gene in the absence of an immune response
Abstract:	A method of gene transfer involving administering a recombinant adeno-associated virus (AAV) bearing the desired gene into the muscle of the animal is described.
Inventor(s):	Wilson; James M. (Gladwyne, PA), Fisher; Krishna J. (Philadelphia, PA)
Assignee:	The Trustees of the University of Pennsylvania (Philadelphia, PA)
Application Number:	08/708,188
Patent Claims:	1. A method for transducing a skeletal muscle cell with a transgene encoding a protein of interest in the absence of a cytotoxic immune response directed against said cell, comprising the step of introducing into said cell a recombinant adeno-associated virus (rAAV) which is substantially free of contamination with a helper virus, wherein said rAAV comprises said transgene operably linked to sequences which control its expression and wherein said transgene is expressed at detectable levels in said cell in the absence of a cytotoxic immune response directed against said cell. 2. The method according to claim 1 wherein said protein of interest is a secreted protein. 3. The method according to claim 2 wherein said secreted protein is selected from the group consisting of Factor IX, ApoE, .beta.-interferon, insulin, erythropoietin, growth hormone, and parathyroid hormone. 4. The method according to claim 1 wherein said rAAV consists essentially of, from 5' to 3', a 5' AAV ITR sequence, a heterologous promoter, said transgene, a polyadenylation sequence, and 3' AAV ITR sequence.

Details for Patent 5,866,552

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015		2039-03-29