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Last Updated: April 25, 2024

Claims for Patent: 5,851,522

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Summary for Patent: 5,851,522

Title:	Enhancing keratinocyte migration
Abstract:	This invention relates to the use of a particular form of collagenase substantially free of other proteinases to increase the motility of karatinocytes.
Inventor(s):	Herman; Ira M. (Newton, MA)
Assignee:	Trustees of Tufts College (Medford, MA)
Application Number:	08/484,382
Patent Claims:	1. A method of enhancing the migration and proliferation of keratinocytes in human wound healing which comprises contacting same with an effective amount of purified Clostridiopeptidase A collagenase substantially free from other proteinases. 2. A method according to claim 1 wherein said collagenase is applied in the form of an aqueous solution containing from about 0.5 ABC units collagenase/ml to about 150 ABC units/ml. 3. A method according to claim 2 wherein the collagenase concentration is within the range of about 2 to about 50 ABC units/ml. 4. A method of treating an open wound in human skin which comprises contacting exposed sub-cellular matrix with purified Clostridiopeptidase A collagenase substantially free from other proteinases in a concentration effective to enhance the rate of migration of keratinocytes towards the wound edges. 5. A method according to claim 4 wherein said collagenase is applied in the form of an aqueous solution containing from about 0.5 ABC units collagenase/ml to about 150 ABC units/ml. 6. A method according to claim 5, wherein the collagenase concentration is within the range of about 2 to about 50 ABC units/ml. 7. A method of enhancing the migration and proliferation of keratinocytes in mammalian wound healing which comprises contacting same with an effective amount of purified Clostridiopeptidase A collagenase substantially free from other proteinases. 8. A method of treating an open wound in mammalian skin which comprises contacting exposed sub-cellular matrix with purified Clostridiopeptidase A collagenase substantially free from other proteinases in a concentration effective to enhance the rate of migration of keratinocytes at the wound edges.

Details for Patent 5,851,522

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2039-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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