Claims for Patent: 5,849,700

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Summary for Patent: 5,849,700

Title:	Pharmaceutical formulation
Abstract:	A pharmaceutical preparation comprising a growth hormone and histidine or a derivative of histidine as additive or buffering substance shows a very high stability against deamidation, oxidation and cleavage of peptide bonds. The stability of the product allows for the storing and shipment thereof in a lyophilized state or in the form of a dissolved or re-dissolved preparation at ambient temperature. Crystallization of growth hormone in the presence of histidine or a derivative thereof gives rise to a higher yield of crystals having a higher purity than known methods.
Inventor(s):	Hans Holmegaard S.o slashed.rensen, Lars Skriver, Annie Rassing Hoelgaard
Assignee:	Novo Nordisk Health Care AG
Application Number:	US08/458,385
Patent Claims:

Details for Patent 5,849,700

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Novo Nordisk Inc.	NORDITROPIN	somatropin	Injection	021148	June 20, 2000	⤷ Get Started Free	2015-06-02
Novo Nordisk Inc.	NORDITROPIN	somatropin	Injection	021148	October 01, 2004	⤷ Get Started Free	2015-06-02
Novo Nordisk Inc.	NORDITROPIN	somatropin	Injection	021148	March 10, 2009	⤷ Get Started Free	2015-06-02
Novo Nordisk Inc.	NORDITROPIN	somatropin	Injection	021148	March 01, 2010	⤷ Get Started Free	2015-06-02
Novo Nordisk Inc.	NORDITROPIN	somatropin	Injection	021148	January 23, 2015	⤷ Get Started Free	2015-06-02
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 5,849,700

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Country	Patent Number	Estimated Expiration
South Africa	929825	⤷ Get Started Free
World Intellectual Property Organization (WIPO)	9312812	⤷ Get Started Free
United States of America	6022858	⤷ Get Started Free
United States of America	5849704	⤷ Get Started Free
Ukraine	41502	⤷ Get Started Free
Slovakia	75494	⤷ Get Started Free
>Country	>Patent Number	>Estimated Expiration

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