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Last Updated: April 19, 2024

Claims for Patent: 5,814,605


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Summary for Patent: 5,814,605
Title: Therapeutic uses of keratinocyte growth factor
Abstract:Based on extensive in vivo studies in animals, it has now been discovered that KGF stimulates proliferation, growth and differentiation in various cells of epithelial tissue, besides keratinocytes. This better understanding of the biological effects of KGF in vivo enables the use of this polypeptide as a therapeutic agent, suitably formulated in a pharmaceutical composition, for the specific treatment of disease states and medical conditions afflicting tissues and organs such as the dermal adnexae, the liver, the lung, and the gastrointestinal tract.
Inventor(s): Pierce; Glenn Francis (Rancho Santa Fe, CA), Housley; Regina Mae (Thousand Oaks, CA), Morris; Charles Frederick (Newbury Park, CA)
Assignee: Amgen Inc. (Thousand Oaks, CA)
Application Number:08/484,065
Patent Claims:1. A pharmaceutical composition comprising a therapeutically effective amount of a keratinocyte growth factor product and a non-aqueous carrier.

2. The pharmaceutical composition of claim 1, wherein the non-aqueous carrier is selected from the group consisting of collagen, hyaluronic acid and carboxymethylcellulose.

3. The pharmaceutical composition of claim 1, wherein the keratinocyte growth factor product is recombinantly produced keratinocyte growth factor.

4. The pharmaceutical composition of claim 3, wherein the recombinantly produced keratinocyte growth factor is produced in bacterial cells.

5. The pharmaceutical composition of claim 4, wherein the bacterial cells are E. coli.

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