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Last Updated: April 26, 2024

Claims for Patent: 5,747,005

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Summary for Patent: 5,747,005

Title:	Oil-based, anti-plaque dentifrice composition
Abstract:	The present invention provides an oil-based, anti-plaque dentifrice comprising vitamin E and an enzyme in an admixture which is effective to dissolve plaque and to resist plaque formation. The preferred dentifrice composition is substantially anhydrous, and includes a chelating agent and a promoter to assist the enzyme in fighting plaque.
Inventor(s):	Barels; Ronald R. (Escondido, CA), Cohler; Charles M. (San Diego, CA)
Assignee:
Application Number:	08/510,420
Patent Claims:	1. An oil-based, anti-plaque composition for use in an oral cavity, consisting essentially of: at least one enzyme selected from the group consisting of proteases, lipases and saccharinases; and vitamin E, the vitamin E and the enzyme forming a localizing admixture for an oral substrate contacted therewith, the admixture having the vitamin E and the enzyme in a weight ratio of from about 5:2 to about 13:0.01. 2. The composition of claim 1 wherein said composition is substantially anhydrous. 3. The composition of claim 2 wherein the enzyme is derived from the group consisting of pancreatin, trypsin, papain, collagenase, keratinase, carboxylase, aminopeptidase, lactate dehydrogenase and glucosyltransferase. 4. The composition of claim 2 wherein said vitamin E is selected from the group consisting of .alpha.-tocopheryl acetate and .alpha.-tocopheryl succinate. 5. The composition of claim 2, further comprising a chelating agent. 6. The composition of claim 5 wherein the chelating agent includes citric acid or ethylenediaminetetraacetic acid. 7. The composition of claim 2, further comprising a promoter of the enzyme. 8. The composition of claim 7 wherein the promoter includes zinc or selenium. 9. A substantially anhydrous oil-based, anti-plaque composition for use in an oral cavity, consisting essentially of: at least one enzyme selected from the group consisting of proteases, lipases and saccharinases; vitamin E, the vitamin E and the enzyme forming a localizing admixture for an oral substrate contacted therewith; a chelating agent; and a promoter of the enzyme. 10. The composition of claim 9 wherein the enzyme is derived from the group consisting of pancreatin, trypsin, papain, collagenase, keratinase, carboxylase, aminopeptidase, lactate dehydrogenase and glucosyltransferase. 11. The composition of claim 9 wherein said vitamin E is selected from the group consisting of .alpha.-tocopheryl acetate and .alpha.-tocopheryl succinate. 12. The composition of claim 9 wherein the chelating agent includes citric acid or ethylenediaminetetraacetic acid. 13. The composition of claim 9 wherein the promoter includes zinc or selenium. 14. The composition of any one of claims 2 and 9 in a powder form.

Details for Patent 5,747,005

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2039-02-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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