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Last Updated: April 26, 2024

Claims for Patent: 5,660,826

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Summary for Patent: 5,660,826

Title:	Therapeutic sepsis treatment using antagonists to PTHrP
Abstract:	Methods and compositions are provided for the treatment or prophylaxis of systematic inflammatory response syndrome by administering an antagonist to parathyroid hormone-related protein, such as antibodies to PTHrP.
Inventor(s):	Grunfield; Carl (San Francisco, CA), Funk; Janet (San Francisco, CA), Feingold; Kenneth R. (San Rafael, CA)
Assignee:	The Regents of the University of California (Oakland, CA)
Application Number:	08/477,348
Patent Claims:	1. A method comprising: administering to a patient suffering from risk of systemic inflammatory response syndrome (SIRS) a pharmaceutically effective amount of antibodies to parathyroid hormone related protein (PTHrP), the amount administered being effective in reducing or delaying at least some of the toxic effects of endotoxin or cytokine. 2. The method as in claim 1 wherein the pharmaceutically effective amount is about 1 .mu.g/kg to 10 mg/kg of patient body weight. 3. The method as in claim 1 wherein the administration is by continuous infusion or bolus infusion. 4. The method as in claim 1 wherein the administration is to a patient having a microbial infection but not yet showing symptoms of septic shock. 5. The method as in claim 1 wherein the antibodies to PTHrP are administered with an anti-microbial agent. 6. The method as in claim 1 wherein the antibodies to PTHrP are monoclonal antibodies. 7. The method as in claim 1 wherein the SIRS is septic shock. 8. The method as in claim 7 wherein the administering is in conjunction with an additional cytokine antagonist. 9. The method as in claim 7 wherein the additional cytokine antagonist is an anti-TNF agent, an IL-1 antagonist, or an inhibitor of platelet activating factor.

Details for Patent 5,660,826

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015	⤷ Try a Trial	2039-02-26
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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