Claims for Patent: 5,629,209

Summary for Patent: 5,629,209

Title:	Method and apparatus for detecting viscosity changes in fluids
Abstract:	An apparatus for detecting changes in the viscosity of a fluid comprises a cartridge having a fluid receiving/dispensing reservoir, one or more fluid-receiving chambers, and a conduit that permits fluid communication between the fluid receiving/dispensing reservoir and the fluid-receiving chamber. Fluid is introduced into the cartridge through an injection port and fills the reservoir, moving from the reservoir through the conduit into the chamber. An air vent/fluid plug device in fluid communication with the chamber permits air to exit while the fluid enters the system but prevents the fluid from leaving after the chamber is filled. A freely movable ferromagnetic material is placed within the fluid-receiving chamber and is caused to move by an electromagnet. Changes in the viscosity of the fluid are detected by determining the position of the ferromagnetic material in the fluid-receiving chamber.
Inventor(s):	Braun, Sr.; Walter J. (Aurora, CO), Boiarski; Anthony A. (Upper Arlington, OH), Braun, Jr.; Walter J. (Aurora, CO), Braun; Steven P. (Peoria, AZ)
Assignee:
Application Number:	08/545,523
Patent Claims:	1. An apparatus for detecting changes in viscosity of a fluid, said apparatus comprising: a cartridge having a fluid receiving/dispensing reservoir, one or more fluid-receiving chambers, and a plurality of conduits, each of which permits fluid communication between the fluid receiving/dispensing reservoir and each fluid-receiving chamber; an injection port in the cartridge for introducing fluid into the fluid receiving/dispensing reservoir; a plurality of air vent/fluid plug devices, each of which is in fluid communication with each fluid-receiving chamber; a ferromagnetic material that is free to move in each fluid-receiving chamber; means for moving the ferromagnetic material in the fluid-receiving chamber; and means for detecting a position of the ferromagnetic material in the fluid-receiving chamber. 2. The apparatus of claim 1 wherein a viscosity-altering substance is placed within the cartridge such that fluid introduced into the cartridge will come into contact with the viscosity-altering substance. 3. The apparatus of claim 1 further comprising at least two fluid-receiving chambers for comparing changes in viscosity of the fluid. 4. The apparatus of claim 1 wherein the air vent/fluid plug device vents air displaced from the fluid receiving/dispensing reservoir, the conduit, and the fluid-receiving chamber but prevents fluid from leaving the cartridge via the air vent/fluid plug device. 5. The apparatus of claim 1 wherein the fluid receiving/dispensing reservoir is adapted to dispense fluid simultaneously to more than one fluid-receiving chamber. 6. The apparatus of claim 1 wherein the ferromagnetic material is disk shaped. 7. The apparatus of claim 1 wherein the ferromagnetic material is washer shaped. 8. The apparatus of claim 1 wherein the means for moving the ferromagnetic material is an electromagnet. 9. The apparatus of claim 1 wherein the means for detecting the position of the ferromagnetic material is a radio frequency detector. 10. The apparatus of claim 1 wherein the fluid is human blood. 11. An apparatus for detecting changes in viscosity of human blood, said apparatus comprising: a cartridge having a blood receiving/dispensing reservoir, two to six blood-receiving chambers, and a plurality of conduits, each of which permits fluid communication between the blood receiving/dispensing reservoir and each of the blood-receiving chambers; an injection port in the cartridge for introducing blood into the blood receiving/dispensing reservoir; a plurality of air vent/fluid plug devices, each of which is in fluid communication with each blood-receiving chamber in a manner that permits air to vent from the blood receiving/dispensing reservoir, the conduit, and the blood-receiving chamber as blood is introduced into the blood receiving/dispensing reservoir but prevents blood from leaving the cartridge via the air vent/fluid plug device; a ferromagnetic material that is free to move within each of the blood-receiving chambers; means for moving the ferromagnetic material within the blood-receiving chambers; and means for detecting a position of the ferromagnetic material within the blood-receiving chambers. 12. The apparatus of claim 11 further comprising a viscosity-altering substance placed within the cartridge such that blood introduced into the cartridge will come into contact with the viscosity-altering substance. 13. The apparatus of claim 11 wherein the blood receiving/dispensing reservoir is adapted to dispense blood simultaneously to more than one blood-receiving chamber. 14. The apparatus of claim 11 wherein the ferromagnetic material is disk shaped. 15. The apparatus of claim 11 wherein the ferromagnetic material is washer shaped. 16. The apparatus of claim 11 wherein the means for moving the ferromagnetic material is an electromagnet. 17. The apparatus of claim 11 wherein the means for detecting the position of the ferromagnetic material is a radio frequency detector. 18. An apparatus for detecting changes in viscosity of human blood, said apparatus comprising: a cartridge having a blood receiving/dispensing reservoir, two to six blood-receiving chambers, and a plurality of conduits, each of which permits fluid communication between the blood receiving/dispensing reservoir and the blood-receiving chambers, said blood receiving/dispensing reservoir adapted to dispense blood simultaneously to more than one blood-receiving chamber; an injection port in the cartridge for introducing blood into the blood receiving/dispensing reservoir; a plurality of air vent/fluid plug devices, each of which is in fluid communication with each blood-receiving chamber in a manner that permits air to vent from the blood receiving/dispensing reservoir, the conduit, and each of the blood-receiving chambers as blood is introduced into the blood receiving/dispensing reservoir but prevents blood from leaving the cartridge via the air vent/fluid plug device; a blood viscosity-altering substance placed within the cartridge such that blood introduced into the cartridge will come into contact with said blood viscosity-altering substance; a ferromagnetic disk that is free to move within each blood-receiving chamber; an electromagnet for moving the ferromagnetic disk within each blood-receiving chamber; and means for detecting a position of the ferromagnetic disk within each blood-receiving chamber. 19. The apparatus of claim 18 wherein the blood is anticoagulated with an anticoagulant selected from the group consisting of heparin, warfarin, dicumarol, acenocoumarol, phenprocoumon, diphenadione, phenindione, sodium citrate, citric acid, citrate dextrose, citrate phosphate dextrose, aspirin, and edetate disodium. 20. The apparatus of claim 18 wherein the blood viscosity-altering substance is selected from the group consisting of protamine, platelet-activating factor, factor VIII, factor IX complex, factor XVII, fibrinogen, aminocaproic acid, thrombin, thromboplastin, vitamin K, calcium chloride, kaolin, and diatomaceous earth. 21. The apparatus of claim 20 wherein the amount of blood viscosity-altering substance in each of blood-receiving chambers varies. 22. The apparatus of claim 18 wherein the means for detecting the position of the ferromagnetic disk is a radio frequency detector. 23. The apparatus of claim 18 wherein the ferromagnetic disk is washer shaped. 24. A method for detecting changes in viscosity of a fluid, said method comprising the steps of: (a) heating to an optimal temperature a cartridge having a fluid receiving/dispensing reservoir, one or more fluid-receiving chambers, and a plurality of conduits, each of which permits fluid communication between said fluid receiving/dispensing reservoir and each of said fluid-receiving chambers; (b) introducing the fluid into the fluid receiving/dispensing reservoir via an injection port in the cartridge; (c) venting the air displaced from the fluid receiving/dispensing reservoir, conduit, and fluid-receiving chamber via an air vent/fluid plug device that is in fluid communication with each fluid-receiving chamber; (d) inducing motion in a freely movable ferromagnetic material residing in each fluid-receiving chamber, said ferromagnetic material to detect changes in viscosity of the fluid; (e) allowing the ferromagnetic material to come to rest for a period; and (f) detecting a position of the ferromagnetic material in the fluid-receiving chamber. 25. The method of claim 24 further comprising repeating steps (d) and (e). 26. The method of claim 24 further comprising preventing the fluid from leaving the cartridge via the air vent/fluid plug device. 27. The method of claim 24 further comprising contacting the fluid with a viscosity-altering substance within the cartridge. 28. The method of claim 24 wherein the motion of the ferromagnetic material is induced through the action of an electromagnet. 29. The method of claim 24 wherein the position of the ferromagnetic material is detected through the action of a radio frequency detector. 30. The method of claim 24 wherein the optimal temperature is 98.6 degrees Fahrenheit plus or minus 2 degrees Fahrenheit. 31. The method of claim 24 wherein the fluid is human blood.

Details for Patent 5,629,209

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Biologicals Llc	PROFILNINE, PROFILNINE HP, PROFILNINE HT, PROFILNINE SD	factor ix complex	For Injection	102476	07/20/1981		2040-01-28