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Last Updated: April 25, 2024

Claims for Patent: 5,605,690

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Summary for Patent: 5,605,690

Title:	Methods of lowering active TNF-.alpha. levels in mammals using tumor necrosis factor receptor
Abstract:	A method for treating TNF-dependent inflammatory diseases in a mammal by administering a TNF antagonist, such as soluble TNFR.
Inventor(s):	Jacobs; Cindy A. (Seattle, WA), Smith; Craig A. (Seattle, WA)
Assignee:	Immunex Corporation (Seattle, WA)
Application Number:	08/385,229
Patent Claims:	1. A method for lowering the levels of active TNF-.alpha. in a mammal in need thereof which comprises administering to said mammal a TNF-lowering amount of a TNF antagonist selected from the group consisting of: (a) a TNF receptor comprising the sequence of amino acids 3-163 of SEQ ID NO:1; and (b) a chimeric antibody comprising a TNF receptor according to (a) fused to the constant domain of an immunoglobulin molecule. 2. A method for lowering the levels of active TNF-.alpha. in a mammal in need thereof which comprises administering to said mammal a TNF-lowering amount of a TNF receptor comprising the sequence of amino acids 3-163 of SEQ ID NO:1. 3. A method for lowering the levels of active TNF-.alpha. in a mammal in need thereof which comprises administering to said mammal a TNF-lowering amount of a chimeric antibody comprising a TNF receptor comprising the sequence of amino acids 3-163 of SEQ ID NO:1 fused to the constant domain of an immunoglobulin molecule. 4. A method for lowering the levels of active TNF-.alpha. in a mammal having arthritis, which comprises administering to such mammal a therapeutically effective amount of a TNF-antagonist selected from the group consisting of: (a) a TNF receptor comprising the sequence of amino acids 3-163 of SEQ ID NO:1; and (b) a chimeric antibody comprising a TNF receptor according to (a) fused to the constant domain of an immunogloblin molecule. 5. A method for lowering the levels of active TNF-.alpha. in a mammal having arthritis, which comprises administering to said mammal a TNF-lowering amount of a TNF receptor comprising the sequence of amino acids 3-163 of SEQ ID NO:1. 6. A method for lowering the levels of active TNF-.alpha. in a mammal having arthritis, which comprises administering to said mammal a TNF-lowering amount of a chimeric antibody comprising a TNF receptor comprising the sequence of amino acids 3-163 of SEQ ID NO:1 fused to the constant domain of an immunoglobulin molecule.

Details for Patent 5,605,690

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Immunex Corporation	ENBREL	etanercept	For Injection	103795	11/02/1998	⤷ Try a Trial	2014-02-25
Immunex Corporation	ENBREL	etanercept	For Injection	103795	05/27/1999	⤷ Try a Trial	2014-02-25
Immunex Corporation	ENBREL	etanercept	Injection	103795	09/27/2004	⤷ Try a Trial	2014-02-25
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 5,605,690

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Country	Patent Number	Estimated Expiration
Austria	131871	⤷ Try a Trial
Austria	242322	⤷ Try a Trial
Australia	3970293	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration

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