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Last Updated: December 30, 2025

Claims for Patent: 5,565,204


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Summary for Patent: 5,565,204
Title:Pneumococcal polysaccharide-recombinant pneumolysin conjugate vaccines for immunization against pneumococcal infections
Abstract:Immunogenic polysaccharide-protein conjugates are generated which have an oxidized polysaccharide derived from the capsular polysaccharide of Streptococcal pneumniae and the pneumolysin protein of S. pneumoniae which is expressed recombinantly. The pneumolysin is not toxoided prior to conjugation with said oxidized polysaccharide. The immunogenic conjugates are used as vaccines to elicit antibody responses to the capsular polysaccharide of S. pneumoniae and to recombinant pneumolysin, and to immunize against S. pneumoniae-caused disease.
Inventor(s):Joseph S.-C. Kuo, Heesoo K. Ree
Assignee: Wyeth Holdings LLC
Application Number:US08/295,305

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