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Summary for Patent: 5,545,405
|Title:||Method for treating a mammal suffering from cancer with a cho-glycosylated antibody|
|Abstract:||The invention relates to a CHO cell-line capable of producing antibody, the cell-line having been co-transfected with a vector capable of expressing the light chain of the antibody and a vector capable of expressing the heavy chain of the antibody wherein the vectors contain independently selectable markers; also included is a CHO cell-line capable of producing a human antibody or an altered antibody, the cell-line having been transfected with a vector capable of expressing the light chain of the antibody and the heavy chain of the antibody; process for the production of antibody using a CHO cell-line and antibody having CHO glycosylation.|
|Inventor(s):||Page; Martin J. (Beckenham, GB)|
|Assignee:||Burroughs Wellcome Co. (Research Triangle Park, NC)|
|Patent Claims:||1. In a method for treating a human suffering from cancer by administering a therapeutically effective amount of a whole glycosylated recombinant human, chimeric, CDR grafted or
bispecific antibody effective in treating said cancer, wherein the improvement comprises an antibody glycosylated by a Chinese hamster ovary cell.
2. A method in accordance with claim 1, wherein the cancer is non-Hodgkins lymphoma.
3. A method in accordance with claim 1, wherein the cancer is multiple myeloma.
4. A method in accordance with claim 3, wherein the antibody specifically recognizes a T cell marker.
5. A method in accordance with claim 4, wherein the antibody is an anti-CDw52 antibody.
6. A method in accordance with claim 1, wherein the antibody specifically recognizes a cancer cell marker antigen.
7. A method in accordance with claim 6, wherein the antibody is an anti-CD33 antibody or an anti-CD38 antibody.
8. A method in accordance with claim 1, wherein the antibody is administered in a daily dose of about 1 mg to about 10 mg.
9. A method in accordance with claim 1, wherein the antibody is administered for a period of about 1 to about 30 days.
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|Foriegn Application Priority Data|
|Foreign Country||Foreign Patent Number||Foreign Patent Date|
|United Kingdom||9022543||Oct 17, 1990|
|Applicant||Tradename||Biologic Ingredient||Dosage Form||BLA||Number||Approval Date||Patent No.||Assignee||Estimated Patent Expiration||Status||Orphan||Source|
|Genzyme||CAMPATH||alemtuzumab||VIAL; INTRAVENOUS||103948||001||2001-05-07||Try a Free Trial||Burroughs Wellcome Co. (Research Triangle Park, NC)||2013-08-13||RX||Orphan||company|
|Genzyme||CAMPATH||alemtuzumab||VIAL; INTRAVENOUS||103948||002||2001-05-07||Try a Free Trial||Burroughs Wellcome Co. (Research Triangle Park, NC)||2013-08-13||RX||Orphan||company|
|Genzyme||LEMTRADA||alemtuzumab||INJECTABLE;INJECTION||103948||003||2001-05-07||Try a Free Trial||Burroughs Wellcome Co. (Research Triangle Park, NC)||2013-08-13||RX||Orphan||company|
|>Applicant||>Tradename||>Biologic Ingredient||>Dosage Form||>BLA||>Number||>Approval Date||>Patent No.||>Assignee||>Estimated Patent Expiration||>Status||>Orphan||>Source|
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