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Last Updated: May 10, 2024

Claims for Patent: 5,503,841


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Summary for Patent: 5,503,841
Title: Human IL-2 as a vaccine adjuvant
Abstract:Methods for enhancing the immune response to vaccination in animals, including humans, comprise administering interleukin-2 (IL-2) as part of the vaccination regimen, preferably for 5 to 14 days post-vaccination. In addition, compositions for enhancing the immune response of an animal to a vaccine employ IL-2 as an active ingredient, preferably human IL-2.
Inventor(s): Doyle; Michael V. (Oakland, CA), Newell; Arthur D. (Orinda, CA), Nunberg; Jack H. (Oakland, CA), White; Thomas J. (Oakland, CA)
Assignee: Cetus Oncology Corporation (Emeryville, CA)
Application Number:07/314,975
Patent Claims:1. A method of enhancing the immune response of a subject animal to an immunoprophylactic, infectious disease vaccine comprising administering an effective amount of interleukin-2 (IL-2) to the subject as part of the immunoprophylactic vaccination regimen before the infection.

2. The method of claim 1 wherein the IL-2 is human IL-2.

3. The method of claim 2 wherein the human IL-2 is des-alanyl-rIL-2.sub.ser125.

4. The method of claim 2 wherein the human IL-2 is a water soluble form of human IL-2.

5. The method of claim 4 wherein the water soluble form of human IL-2 is PEGylated human IL-2 or succinylated human IL-2.

6. The method of claim 1 wherein the IL-2 is in the form of a continuous release formulation.

7. The method of claim 1 wherein the IL-2 is in the form of a single sustained action formulation.

8. The method of claim 1 wherein the vaccine is an Escherichia coli bacterin, Haemophilus bacterin, Pasteurella bacterin, Vibrio fetus bacterin, transmissible gastroenteritis vaccine, equine influenza vaccine, feline leukemia vaccine, rabies vaccine, or pseudorabies vaccine.

9. The method of claim 1 wherein the IL-2 is administered subsequent to the administration of the vaccine.

10. The method of claim 6 wherein the IL-2 is administered continuously at a rate of above about 10.sup.3 and below about 10.sup.6 units/kg/day for about 5 to 30 days post-vaccination.

11. A method for enhancing the immune response of a human to an immunoprophylactic, infectious disease vaccine, which method comprises administering an effective amount of human interleukin-2 (hIL-2) to the human as part of the immunoprophylactic vaccination regimen before the infection.

12. The method of claim 11 wherein the hIL-2 is a water-soluble form of hIL-2.

13. The method of claim 12 wherein the hIL-2 is PEGylated or succinylated IL-2.

14. The method of claim 11 wherein the hIL-2 is des-alanyl-rIL-2.sub.ser125.

15. The method of claim 11 wherein the hIL-2 is in the form of a continuous release formulation.

16. The method of claim 11 wherein the hIL-2 is in the form of a single sustained action formulation.

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