Claims for Patent: 5,476,777

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Summary for Patent: 5,476,777

Title:	Methods for producing thrombin
Abstract:	Methods are disclosed for producing thrombin. The protein is produced from host cells transformed or transfected with DNA construct(s) containing information necessary to direct the expression of thrombin precursors. The DNA constructs generally include the following operably linked elements: a transcriptional promoter, DNA sequence encoding a gla-domainless prothrombin, and a transcriptional terminator. Thrombin precursors produced from transformed or transfected host cells are activated either in vivo or in vitro.
Inventor(s):	Richard D. Holly, Donald C. Foster
Assignee:	Medicines Co
Application Number:	US07/998,972

Details for Patent 5,476,777

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Baxter Healthcare Corporation	RECOTHROM	thrombin topical (recombinant)	For Solution	125248	January 17, 2008	⤷ Get Started Free	2012-12-30
Baxter Healthcare Corporation	RECOTHROM	thrombin topical (recombinant)	For Solution	125248	May 23, 2008	⤷ Get Started Free	2012-12-30
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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