Claims for Patent: 5,429,600

Summary for Patent: 5,429,600

Title:	Method for delivering a pharmaceutical into the nostril of an animal
Abstract:	A syringe is described including a plastic barrel having a unitary needle extending from one end thereof which is normally shielded by a nasal tip-seal cap. A plunger is movably mounted in the barrel for aspirating the contents of the barrel or for drawing liquid into the barrel. The nasal tip-seal cap may be deflected or compressed with respect to the shielded needle so that the needle will pierce therethrough to enable the needle to be in communication with the interior of a pharmaceutical vial. The method of using the syringe of the invention to nasally vaccinate an animal or nasally vaccinate a human is also described.
Inventor(s):	Heinke; Richard M. (Lincoln, NE)
Assignee:
Application Number:	08/236,275
Patent Claims:	1. The method of delivering a pharmaceutical into the nasal passage of a living creature, comprising the steps of: (a) providing a syringe including an elongated hollow barrel having a rearward end and a forward end and being comprised of a plastic material; said barrel having a rear opening at its rear end; said barrel having a rear opening stop provided thereon; said barrel having a first compartment provided therein which extends forwardly from said rear opening for receiving a plunger therein; said barrel having a hollow needle at its forward end, said needle having a proximal end in communication with said forward end of said barrel and a pointed distal end; a flexible tip and cap seal mounted on the forward end of said barrel which normally encloses said needle but which may be deflected rearwardly with respect to said needle to permit said pointed distal end of said needle to pierce therethrough to expose said pointed distal end of said needle; and a plunger selectively movably mounted on said first compartment of said barrel including a piston mounted thereon for aspirating any material in said first compartment through said needle when said plunger is moved forwardly into said first compartment and for drawing material inwardly through said needle and into said first compartment when said plunger is moved rearwardly with respect to said barrel; (b) providing a vial which has a freeze-dried pharmaceutical therein and which is maintained therein by a cap means; (c) placing a diluent in said first compartment; (d) positioning said flexible tip and seal cap on said cap means; (e) longitudinally moving said barrel of said syringe with respect to said vial to cause said needle to pierce through said tip and cap seal and to pierce through said cap means of said vial so that said pointed distal end of said needle is in communication with the interior of said vial; (f) moving said plunger with respect to said barrel to aspirate the diluent in said compartment into said vial; (g) mixing the diluent with the pharmaceutical; (h) moving said plunger with respect to said barrel to draw the pharmaceutical-diluent mixture from said vial into said first compartment; (i) disengaging said syringe from said vial so that said needle is again enclosed by said tip and cap seal; (j) inserting the tip and cap seal into the nostril of the living creature; (k) moving said plunger inwardly into said barrel to aspirate the pharmaceutical-diluent mixture into the nostril of the living creature; and (l) removing the tip and cap seal from the nostril of the living creature. 2. The method of claim 1 wherein said diluent is sterile water. 3. The method of claim 1 wherein said freeze-dried pharmaceutical comprises a serum. 4. The method of claim 1 wherein said pharmaceutical-diluent mixture comprises a vaccine.

Details for Patent 5,429,600

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006		2039-09-23