Claims for Patent: 5,407,911

Summary for Patent: 5,407,911

Title:	Parathyroid hormone-containing emulsion for nasal administration
Abstract:	A parathyroid hormone-containing emulsion for nasal administration, comprising parathyroid hormone as the active ingredient, at least, azacycloalkane derivative of the general formula [1]: ##STR1## wherein R is alkyl, m is an integer of 2-4, and n is an integer of 1-15, provided that R is alkyl of C.sub.5-11 in case where n is 1-3, as the absorption promotor, glycyrrhizic acid or its non-toxic salt, and a suitable amount of water.
Inventor(s):	Yamamoto; Nakayuki (Tagata, JP), Sugimoto; Michihiko (Numazu, JP), Morimoto; Seiki (Tagata, JP), Sakakibara; Hideo (Shizuoka, JP), Saita; Masaru (Miyaki, JP), Shimozono; Yuji (Tosu, JP), Manako; Takafumi (Miyaki, JP)
Assignee:	Asahi Kasei Kogyo Kabushiki Kaisha (Osaka, JP) Hisamitsu Keiyaku Kabushiki Kaisha (Saga, JP)
Application Number:	08/211,035
Patent Claims:	1. A parathyroid hormone-containing emulsion for nasal administration, comprising parathyroid hormone as the active ingredient, and containing, at least, an azacycloalkane derivative of the formula [1]: ##STR3## wherein R is alkyl, m is an integer of 2-4, and n is an integer of 1-15, provided that R is alkyl of C.sub.5-11 in case where n is 1-3, as the absorption promotor, glycyrrhizic acid or its non-toxic salt, and a suitable amount of water. 2. An emulsions according to claim 1 wherein the azacycloalkane derivative of the formula [1] is 1-[2-(decyl thio)ethyl ]azacyclopentan-2-one, wherein R is alkyl of C.sub.10, m is 3, and n is 2. 3. An emulsions according to claim 1 wherein the content of parathyroid hormone is 10-10,000 Units per 1 ml of the emulsion. 4. An emulsions according to claim 1 wherein the amount of glycyrrhizic acid or its non-toxic salt is 0.1-5% (W/V) per emulsion. 5. An emulsions according to claim 1 wherein the amount of azacycloalkane derivative is 0.1-10% (W/V) per emulsion. 6. An emulsions according to claim 1 comprising human parathyroid hormone (1-34), glycyrrhizic acid or its non-toxic salt and 1-[2-(decyl thio)ethyl]-azacyclopentan-2-one. 7. An emulsion according to claim 4 wherein the non-toxic salt of glycyrrhizic acid is dipotassium glycyrrhizate. 8. An emulsion according to claim 1 wherein the pH of emulsion is ph 5-7. 9. An emulsion according to claim 1 wherein the emulsion is an oil in water type emulsion with 0.1-0.3 .mu.m particle size.

Details for Patent 5,407,911

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015		2012-04-18