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Last Updated: April 25, 2024

Claims for Patent: 5,395,760

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Summary for Patent: 5,395,760

Title:	DNA encoding tumor necrosis factor-.alpha. and -.beta. receptors
Abstract:	Tumor necrosis factor receptor proteins, DNAs and expression vectors encoding TNF receptors, and processes for producing TNF receptors as products of recombinant cell culture, are disclosed.
Inventor(s):	Smith; Craig A. (Seattle, WA), Goodwin; Raymond G. (Seattle, WA), Beckmann; M. Patricia (Poulsbo, WA)
Assignee:	Immunex Corporation (Seattle, WA)
Application Number:	07/523,635
Patent Claims:	1. An isolated DNA sequence consisting of a DNA sequence encoding only the amino acid sequence selected from the group consisting of amino acids 1-235 of FIG. 2A and amino acids 1-233 of FIG. 3A. 2. An isolated DNA sequence according to claim 1 which encodes a soluble human TNF-R. 3. An isolated DNA sequence consisting of a DNA sequence encoding only the amino acid sequence selected from the group consisting of amino acids 1 through x of FIG. 2A, wherein x is amino acid 163-235 of FIG. 2A. 4. An isolated DNA sequence according to claim 1 which encodes a soluble human TNF-R comprising the sequence of amino acids 1-235 of FIG. 2A. 5. An isolated DNA sequence according to claim 1 which encodes a soluble human TNF-R comprising the sequence of amino acids 1-185 of FIG. 2A. 6. An isolated DNA sequence consisting of a DNA sequence encoding only the amino acid sequence 1-163 of FIG. 2A. 7. An isolated DNA sequence according to claim 1 encoding the TNF-R polypeptide expressed by pCAV/NOT-TNF-R (ATCC 68088). 8. A recombinant expression vector comprising a DNA sequence according to claim 1. 9. A recombinant expression vector comprising a DNA sequence according to claim 2. 10. A recombinant expression vector comprising a DNA sequence according to claim 3. 11. A recombinant expression vector comprising a DNA sequence according to claim 4. 12. A recombinant expression vector comprising a DNA sequence according to claim 5. 13. A recombinant expression vector comprising a DNA sequence according to claim 6. 14. A recombinant expression vector comprising a DNA sequence according to claim 7. 15. A host cell transformed or transfected with the vector according to claim 9. 16. A host cell transformed or transfected with the vector according to claim 10. 17. A host cell transformed or transfected with the vector according to claim 11. 18. A host cell transformed or transfected with the vector according to claim 12. 19. A host cell transformed or transfected with the vector according to claim 13. 20. A host cell transformed or transfected with the vector according to claim 14.

Details for Patent 5,395,760

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Immunex Corporation	ENBREL	etanercept	For Injection	103795	11/02/1998	⤷ Try a Trial	2012-03-07
Immunex Corporation	ENBREL	etanercept	For Injection	103795	05/27/1999	⤷ Try a Trial	2012-03-07
Immunex Corporation	ENBREL	etanercept	Injection	103795	09/27/2004	⤷ Try a Trial	2012-03-07
Immunex Corporation	ENBREL	etanercept	Injection	103795	02/01/2007	⤷ Try a Trial	2012-03-07
Immunex Corporation	ENBREL MINI	etanercept	Injection	103795	09/14/2017	⤷ Try a Trial	2012-03-07
Immunex Corporation	ENBREL	etanercept	Injection	103795		⤷ Try a Trial	2012-03-07
Immunex Corporation	ENBREL	etanercept	Injection	103795	03/05/2020	⤷ Try a Trial	2012-03-07
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

International Patent Family for US Patent 5,395,760

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Country	Patent Number	Estimated Expiration
Austria	131871	⤷ Try a Trial
Austria	242322	⤷ Try a Trial
Australia	3970293	⤷ Try a Trial
Australia	4920993	⤷ Try a Trial
Australia	6178190	⤷ Try a Trial
Australia	630497	⤷ Try a Trial
Australia	670125	⤷ Try a Trial
>Country	>Patent Number	>Estimated Expiration

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