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Last Updated: May 10, 2024

Claims for Patent: 5,344,644

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Summary for Patent: 5,344,644

Title:	Water-soluble composition for sustained-release
Abstract:	A water soluble composition is described which comprises (a) a water soluble pharmacologically active peptide selected from the group consisting of cytokines or haematopoietic factors and (b) a sulfate group-containing acidic mucopolysaccharide and/or a desulfated modification of a naturally occurring sulfate group containing acidic mucopolysaccharide, and which brings about prolonged action of pharmacologically active peptides in a living body.
Inventor(s):	Igari; Yasutaka (Kobe, JP), Yamada; Minoru (Kawanishi, JP), Ishiguro; Seiko (Kawanishi, JP)
Assignee:	Takeda Chemical Industries, Ltd. (Osaka, JP)
Application Number:	07/919,401
Patent Claims:	1. A water-soluble parenteral composition for injection which comprises (a) a water soluble pharmacologically active peptide selected from the group consisting of cytokines or hematopoietic factors, and (b) an alkali metal salt of a sulfate group-containing acidic mucopolysaccharide and/or a desulfated modification of a naturally occurring sulfate group-containing acidic mucopolysaccharide, wherein the weight ratio between (a) and (b) is about 0.001 to about 1:1, and wherein prior to injection, the tonicity and viscosity of the composition are adjusted by the addition of sterile water or sterile saline, to obtain a solution such that the viscosity of the solution is lower than 500 cP and the tonicity of the solution is from one-half to twice as high as that of physiological saline. 2. A water-soluble composition as claimed in claim 1, wherein the water-soluble pharmacologically active peptide is erythropoietin, granulocyte colony stimulating factor (G-CSF), macrophage colony stimulating factor (M-CSF), granulocyte-macrophage colony stimulating factor (GM-CSF), interferons or interleukins. 3. A water-soluble composition as claimed in claim 1, wherein the sulfate group containing acidic mucopolysaccharide and/or the desulfated modification of a naturally occurring sulfate group-containing acidic mucopolysaccharide is chondroitin sulfate, heparan sulfate, keratan sulfate, chondroitin or heparan. 4. A water soluble composition as claimed in claim 1, further comprising a water-soluble protein selected from the group consisting of serum albumin, globulin, collagen and gelatin, wherein the weight ratio between the water-soluble protein and the mucopolysaccharide is from about 0.0001:1 to 100:1. 5. A water soluble composition as claimed in claim 1, wherein the viscosity of said solution of the water soluble composition is lower than 400 cP.

Details for Patent 5,344,644

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006	⤷ Try a Trial	2011-09-06
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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