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Last Updated: April 26, 2024

Claims for Patent: 5,342,616

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Summary for Patent: 5,342,616

Title:	Method of administering tissue plasminogen activator
Abstract:	The use of bolus injections of t-PA in the treatment of human beings with a thrombotic disorder.
Inventor(s):	Cohen; Adam F. (EN Oegstgeest, NL)
Assignee:	The Wellcome Foundation Limited (London, GB2)
Application Number:	07/994,083
Patent Claims:	1. A method for the treatment of a human being with a thrombotic disorder wherein t-PA, having the amino acid sequence set forth in FIG. 1 or an amino acid sequence that is at least 90% homologous with that set forth in FIG. 1, is administered by direct injection into a peripheral vein to the human being as a serial bolus injection of at least 25 MU of t-PA per injection. 2. A method according to claim 1, wherein t-PA has the amino acid sequence set forth in FIG. 1 or has the same amino acid sequence both the amino acid in the 245th position from the serine N-terminus being valine instead of methionine. 3. A method according to claim 1 or claim 2, wherein the thrombotic disorder is a myocardial infarction. 4. A method according to claim 1, wherein the amount of t-PA per injection is from 25 to 75 MU. 5. A method according to claim 4, wherein the amount of t-PA per injection is from 25 to 50 MU. 6. A method for the treatment of a human being with a thrombotic disorder wherein an aqueous solution consisting essentially of t-PA, having the amino acid sequence set forth in FIG. 1 or an amino acid sequence that is at least 90% homologous with that set forth in FIG. 1, dissolved in said aqueous solution is administered by direct injection into a peripheral vein to the human being as a serial bolus injection of at least 25 MU of t-PA per injection. 7. A method according to claim 6 wherein the aqueous solution is said t-PA dissolved in sterile water for injection or pyrogen-free water for injection. 8. A method according to claim 7, wherein the aqueous solution also contains dextrose.

Details for Patent 5,342,616

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006	⤷ Try a Trial	2011-08-30
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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