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Last Updated: May 20, 2024

Claims for Patent: 4,983,393

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Summary for Patent: 4,983,393

Title:	Intra-vaginal device and method for sustained drug release
Abstract:	The invention disclosed provides an intra-vaginal device prepared using ingredients which slowly release in the vagina over a significant period of time. The present intra-vaginal device also usefully serves as a drug release means for controllably releasing a drug in the vagina. A method for controlled drug release in the vagina is also disclosed.
Inventor(s):	Cohen; Robert S. (New York, NY), Pierce; James M. (Coral Gables, FL), Kinsey; William H. (Coral Gables, FL)
Assignee:	MaxiMed Corporation (New York, NY)
Application Number:	07/257,156
Patent Claims:	1. A solid, shaped, integral, solidified composition suitable for use as an intra-vaginal insert and capable of dissolution or disintegration in the presence of vaginal fluids, comprising agarose in an amount from about 0.1% to about 4% by weight, agar in that amount of about 0.1% to about 4% by weight, saline solution, high molecular weight glycosaminoglycans of about 100,000 Daltons to about 1,000,000 Daltons in an amount from about 0.1% to about 20% by weight, collagen in an amount from about 0.1% to about 20% by weight, fibrin in an amount from about 0.1% to about 20% by weight and an enzyme selected from the group consisting of agarase, protease, collagenase and saccharidase, said enzyme being present in said composition in an amount from about 0% to about 10% by weight. 2. A composition in accordance with claim 1 wherein said composition contains a spermicide. 3. A composition in accordance with claim 1 wherein said composition contains a germicide. 4. A composition in accordance with claim 1 wherein said composition contains a viricide. 5. A method for the sustained intra-vaginal release of a drug which comprises incorporating said drug in a composition in accordance with claim 1 and inserting the resulting composition into the vagina.

Details for Patent 4,983,393

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2039-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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