Claims for Patent: 4,959,210
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Summary for Patent: 4,959,210
Title: | Treatment of genital warts with a combination of liquid nitrogen and recombinant DNA human alpha interferon |
Abstract: | Condylomata Acuminata infections (anogenital warts) are treated in infected patients by administering liquid nitrogen and immediately thereafter beginning administering recombinant DNA human alpha interferon thrice a week for three weeks. The interferon exemplified is recombinant DNA human interferon alfa-2b in which 1.0.times.10.sup.6 International Units are administered by injection to each lesion. The liquid nitrogen is the cryosurgical agent exemplified and it is topically administered to each lesion by conventional means. |
Inventor(s): | Smiles; Kenneth A. (Windsor, NJ), Peets; Edwin A. (New York, NY), Tanner; Daniel J. (Brooklyn, NY) |
Assignee: | Schering Corporation (Kenilworth, NJ) |
Application Number: | 07/265,612 |
Patent Claims: | 1. A method of treating condylomata acuminata infections in patients in need of such treatment comprising administering to each lesion an effective amount of a cryosurgical agent,
followed by administration to each lesion immediately thereafter an effective amount of human alpha interferon.
2. A method of claim 1 wherein the cryosurgical agent is liquid nitrogen. 3. A method of claim 1 wherein the human alpha interferon is recombinant human DNA interferon alfa-2b. 4. A method of claim 1 wherein the human alpha interferon is recombinant human DNA interferon alfa-2a. 5. A method of claim 1 wherein the treatment is sufficiently frequent and for a sufficient length of time to be efficacious. 6. A method of claim 1 wherein the treatment with said interferon is thrice a week for three weeks. 7. A method of claim 3 wherein the treatment with said interferon is thrice a week for three weeks. 8. A method of claim 4 wherein the treatment with said interferon is thrice a week for three weeks. 9. A method of claim 1 wherein the human alpha interferon is administered by intralesional injection and the liquid nitrogen is administered topically. 10. A method of claim 9 wherein the human alpha interferon is recombinant human DNA interferon alfa-2b. |
Details for Patent 4,959,210
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | 06/04/1986 | ⤷ Try a Trial | 2039-03-29 |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | ⤷ Try a Trial | 2039-03-29 | |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | Injection | 103132 | ⤷ Try a Trial | 2039-03-29 | |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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