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Summary for Patent: 4,959,210
|Title:||Treatment of genital warts with a combination of liquid nitrogen and recombinant DNA human alpha interferon|
|Abstract:||Condylomata Acuminata infections (anogenital warts) are treated in infected patients by administering liquid nitrogen and immediately thereafter beginning administering recombinant DNA human alpha interferon thrice a week for three weeks. The interferon exemplified is recombinant DNA human interferon alfa-2b in which 1.0.times.10.sup.6 International Units are administered by injection to each lesion. The liquid nitrogen is the cryosurgical agent exemplified and it is topically administered to each lesion by conventional means.|
|Inventor(s):||Smiles; Kenneth A. (Windsor, NJ), Peets; Edwin A. (New York, NY), Tanner; Daniel J. (Brooklyn, NY)|
|Assignee:||Schering Corporation (Kenilworth, NJ)|
|Patent Claims:||1. A method of treating condylomata acuminata infections in patients in need of such treatment comprising administering to each lesion an effective amount of a cryosurgical agent,
followed by administration to each lesion immediately thereafter an effective amount of human alpha interferon.
2. A method of claim 1 wherein the cryosurgical agent is liquid nitrogen.
3. A method of claim 1 wherein the human alpha interferon is recombinant human DNA interferon alfa-2b.
4. A method of claim 1 wherein the human alpha interferon is recombinant human DNA interferon alfa-2a.
5. A method of claim 1 wherein the treatment is sufficiently frequent and for a sufficient length of time to be efficacious.
6. A method of claim 1 wherein the treatment with said interferon is thrice a week for three weeks.
7. A method of claim 3 wherein the treatment with said interferon is thrice a week for three weeks.
8. A method of claim 4 wherein the treatment with said interferon is thrice a week for three weeks.
9. A method of claim 1 wherein the human alpha interferon is administered by intralesional injection and the liquid nitrogen is administered topically.
10. A method of claim 9 wherein the human alpha interferon is recombinant human DNA interferon alfa-2b.
|Applicant||Tradename||Biologic Ingredient||Dosage Form||BLA||Number||Approval Date||Patent No.||Assignee||Estimated Patent Expiration||Status||Orphan||Source|
|Schering||INTRON A||interferon alfa-2b||VIAL||103132||001||1986-06-04||➤ Sign Up||Schering Corporation (Kenilworth, NJ)||2036-04-30||RX||search|
|Schering||INTRON A||interferon alfa-2b||VIAL||103132||002||1986-06-04||➤ Sign Up||Schering Corporation (Kenilworth, NJ)||2036-04-30||RX||search|
|Schering||INTRON A||interferon alfa-2b||VIAL||103132||003||1986-06-04||➤ Sign Up||Schering Corporation (Kenilworth, NJ)||2036-04-30||RX||search|
|>Applicant||>Tradename||>Biologic Ingredient||>Dosage Form||>BLA||>Number||>Approval Date||>Patent No.||>Assignee||>Estimated Patent Expiration||>Status||>Orphan||>Source|
|Country||Patent Number||Publication Date|
|South Africa||8908234||Jul 25, 1990|
|World Intellectual Property Organization (WIPO)||9004977||Jun 28, 1990|
|World Intellectual Property Organization (WIPO)||9004977||May 17, 1990|
|Philippines||26680||Sep 15, 1992|
|Japan||H03503766||Aug 22, 1991|
|Israel||92161||Jul 12, 1990|
|European Patent Office||0369632||May 23, 1990|
|>Country||>Patent Number||>Publication Date|
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