Claims for Patent: 4,813,431

Summary for Patent: 4,813,431

Title:	Intrapulmonary pressure monitoring system
Abstract:	A pressure sensing device hydraulically coupled with a transducer comprising a closed hydraulic system incorporated within an endotracheal tube to monitor intrapulmonary pressure. The tube employs an hydraulic system for conveying pressure data from a distal sensor, on the tube, to a transducer. The sensor and transducer are connected by a liquid-filled lumen. Use of an hydraulic conduit avoids the errors of gas-filled systems because liquids, such as the water used in this system, are incompressible.
Inventor(s):	Brown; David (Clifton Park, NY)
Assignee:
Application Number:	07/076,156
Patent Claims:	1. An apparatus for measuring air pressure within the lung comprising: a standard endotracheal tube with occlusive cuff to seal the air passageway between the tube surface and tracheal surface when the tube is inserted into the trachea; means for sensing and hydraulically transmitting to a transducing means the pneumobarometric pressure near the distal end of said tube after said end is emplaced within the pulmonary region and where said means for sensing and transmitting comprises a liquid-filled lumen coextensive to and inside the outer surface of said tube, said lumen's distal end terminating with and sealed by a resilient diaphragm and its proximal end terminating with and sealed by a pressure transducer, said diaphragm proximate the distal end of said tube at its outer periphery, said diaphragm being essentially contiguous with said tube's outer surface, the liquid of said liquid-filled lumen thus isolated from the air within said lung; and liquid-phase transducing means for converting the sensed pneumobarometric pressure to a usable data form. 2. The invention of claim 1 wherein said transducing means is an hydraulic pressure transducer which converts the sensed pressure to electrical signals for further processing. 3. An hydraulic mechanism for measuring pressure comprising: an endotracheal tube, having proximal and distal ends, for inserting the distal end thereof into the interior of a body organ and possessing a coextensive integral interior wall chamber, said chamber having a proximal opening therefrom and a distal opening which communicates with the outer periphery of said tube near the distal end thereof and; a liquid pressure transducer connected to and sealing said chamber near said proximal opening; a resilient membrane covering and sealing said distal opening, isolating the interior of said chamber, said membrane located proximate said distal end and being essentially contiguous to said tube's outer periphery, and a liquid to completely fill the closed volume defined by said transducer, said chamber and said membrane, said liquid to be completely isolated from any fluid within said organ, whereby a force exerted upon the surface of said membrane will be transmitted hydraulically and precisely throughout said volume and be rendered readable by the operation of said transducer. 4. The invention of claim 3 wherein said wall chamber further comprises a lumen which extends from the proximal end of said tube and passes co-linearly along and through a standard, cuffed endotracheal tube to exit at said tube's outer surface near its distal end between said distal end and said cuff. 5. The invention of claim 4 wherein said resilient membrane further comprises an annular cuff resembling the standard toroidial occlusive cuff, said cuff communicating with said lumen. 6. The invention of claim 4 wherein said liquid is sterile water. 7. In an apparatus composed of an endotracheal tube having proximal and distal ends and an outer periphery, an improved pneumopressure measurement system comprising the combination of: a liquid-filled lumen having a proximal end and a distal end and placed coextensively within said tube; a resilient, membranous diaphragm which seals said lumen distal end, said diaphragm being positioned proximate to said tube's distal end and residing contiguous to said tube's outer periphery; and a pressure transducer which seals said lumen proximal end so that in combination with said diaphragm, the liquid filling of said lumen is completely contained and isolated from conditions external to said lumen, whereby when said lumen is used in combined operation with said endotracheal tube and, with said tube distal end placed within the site of pneumopressure measurement, the pressure sensed on said diaphragm is hydraulically transmitted to said transducer which converts pressure data to a readable form. 8. The invention of claim 7 wherein the liquid within said lumen is sterile water. 9. A method for measuring lung compliance comprising the steps of: sensing pneumopressure by inserting into the lung through the trachea a liquid filled lumen that is sealed at the distal end by a membranous diaphragm and at the proximal end by an hydraulic transducer so that the liquid of said lumen is isolated from lung fluid; transmitting the pneumopressure sensed within the lung by conveying the pressure sensed on said diaphragm through the liquid of said lumen to the hydraulic transducer; and transducing pneumopressure that has been transmitted to said transducing means to usable, readable information.

Details for Patent 4,813,431

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006		2039-09-23