Claims for Patent: 4,810,388

Summary for Patent: 4,810,388

Title:	Portable intravenous solutions and water for injection apparatus and method
Abstract:	A portable assembly of components that is designed to produce sterile, intravenous solutions and water for injection in the field, under combat conditions and from various sources of raw feedwater. A single frame supports the components of the invention consisting of a pair of manually operated pump handles, a peristaltic pump to which is engaged an inlet feed tube. The device has the ability to suck water from available feedwater sources or from a reserve bottle designed to hold a variety of liquids that may be introduced therein from any available source. Feedwater is pumped into the base of a filter module containing a coarse filter combined with a reserve osmosis filter for an initial prefiltering of the water. Purified water then passes through a carbon exchange column and subsequently an ion exchange column. At this point, ultrapure water is then passed through a sterilizing filter from which it passes through an IV spike in the form of sterile, non-pyrogenic water for injection. Prepackaged, large volume parenteral bags with premeasured dried medicines located inside are provided so that when connected to the IV spike, IV solutions can be created from the reconstituted medicines. The invention is portable, disposable, air dropable, and can produced 20 to 40 liters of sterile, non-pyrogenic intravenous solutions and water for injection prior to shut down by depletion of the filter system.
Inventor(s):	Trasen; Ben (Littleton, CO)
Assignee:
Application Number:	07/093,696
Patent Claims:	1. A portable intravenous solutions method comprising the steps of: A. constructing a frame; B. providing a pump means for pumping liquid to be filtered and attaching said pump means to said frame; C. constructing a filter means and connecting said filter means to said pump means so that said liquid discharged from said pump means is forced through said filter means; D. providing a final stage of said filter means from which sterile, non-pyrogenic intravenous solutions and water for injection is discharged; E. providing a hollow box means,in said frame, with a base and a top, with a rigid center section to which said pump means and said filter means are attached; F. constructing a handle means, which is part of said rigid center section, across said top of said hollow box means for use as a handle in carrying; G. attaching removably attachable top and sides to said base so that easy access to the interior of said box means is attained once said apparatus is placed in operation; and H. attaching a collapsible cranking means to said box means for manual operation of said pump means. 2. The portable intravenous solutions method of claim 1 wherein providing a pump means comprises the steps of: A. connecting a shaft to said cranking means; B. attaching a roller means to said shaft; C. providing an inlet end of a tube, for transmission of liquid to said filter means, and passing said tube inside said roller means so that when said cranking means turns said shaft, said roller means rhythmically compresses said tube against the housing of said pump means causing a suction at said inlet end of said tube; and D. connecting an outlet end of said tube to said filter means. 3. The portable intravenous solutions method of claim 2 further comprising the step of providing a reservoir tank within said box means, for holding a quantity of liquid, constructed with an outlet port to which said inlet end of said tube may be attached. 4. The portable intravenous solutions method of claim 3 wherein constructing a filter means comprises the steps of: A. providing a combination prefilter and reverse osmosis module and placing said combination in a sealed container wherein said prefilter removes coarse contaminants and said reverse osmosis module passes contaminated liquid to a drain and purified liquid to an exit; B. connecting a carbon column means to said exit on said reverse osmosis module so that purified liquid flows therethrough and organic molecules and halogens are removed and purified liquid passes to an exit; and C. attaching an ion exchange column means to said carbon column means exit so that purified liquid flows therethrough and ionizable substances are removed and ultrapure water passes to an exit. 5. The portable intravenous solutions method of claim 4 wherein providing a final stage comprises the steps of: A. connecting a sterilizing filter means to said exit on said ion exchange means that removes pyrogens and any remaining organics so that sterile, non-pyrogenic water for injection is passed to an exit; and B. attaching an intravenous spike means to said sterilizing filter exit so that said sterile, non-pyrogenic intravenous solutions and water for injection may be pumped through said spike means into dry, prepackaged intravenous bags containing measured amounts of medicines for reconstitution. 6. The portable intravenous solutions method of claim 5 further comprising the step of providing a reject valve means for increasing pressure within said filter means by restricting the flow of said contaminated liquid to said drain. 7. The portable intravenous solutions method of claim 6 wherein said step of providing a reject valve means further comprises the step of providing a multi-position restriction means so that when liquid quality at said inlet is high, reject flow rate can be reduced to a minimum without undue fouling of said filter means and when liquid quality at said inlet is low, reject flow rate can be increased so as to reduce fouling of said flter means. 8. The portable intravenous solutions method of claim 7 wherein said method produces 300 ml per minute of sterile, non-pyrogenic intravenous solutions and water for injection from drinking water and 20 to 40 liters of said sterile, non-pyrogenic intravenous solutions and water for injection from all sources of water prior to depletion of said filter means. 9. The portable intravenous solutions method of claim 2 further comprising the step of providing a remote suction tube means, one end of which is conformed to connect with said inlet end of said tube and one end of which may be placed within a remote body of liquid for suction thereof. 10. A portable intravenous solutions method comprising the steps of: A. constructing a frame; B. providing a pump means for pumping liquid to be filtered and attaching said pump means to said frame; C. constructing a filter means and connecting said filter means to said pump means so that said liquid discharged from said pump means is forced through said filter means; D. providing a final stage of said filter means from which sterile water for injection is discharged; E. the step of constructing a frame further comprising the step of providing a hollow box means with a base and a top, with a rigid center section to which said pump means and said filter means are attached; F. Constructing a handle means, which is part of said rigid center section, across said top of said hollow box means for use as a handle in carrying; G. attaching removably attachable top and sides to said base so that easy access to the interior of said box means is attained once said apparatus is placed in operation; H. attaching a collapsible cranking means to said box means for manual operation of said pump means; I. the step of providing a pump means further comprising the step of connecting a shaft to said cranking means; J. attaching a roller means to said shaft; K. providing an inlet end of a tube, for transmission of liquid to said filter means, and passing said tube inside said roller means so that when said cranking means turns said shaft, said roller means rhythmically compresses said tube against the housing of said pump means causing a suction at said inlet end of said tube; L. connecting an outlet end of said tube to said filter means; M. providing a reservoir tank within said box means, for holding a quantity of liquid, constructed with an outlet port to which said inlet end of said tube may be attached; N. providing a combination prefilter and reverse osmosis module and placing said combination in a sealed container wherein said prefilter removes coarse contaminants and said reverse osmosis module passes contaminated liquid to a drain and purified liquid to an exit; O. connecting a carbon column means to said exit on said reverse osmosis module so that purified liquid flows therethrough and organic molecules and halogens are removed and purified liquid passes to an exit; P. attaching an ion exchange column means to said carbon column means exit so that purified liquid flows therethrough and ionizable substances are removed and ultrapure water passes to an exit; Q. connecting a sterilizing filter means to said exit on said ion exchange means that removes pyrogens and any remaining organics so that sterile, non-pyrogenic water for injection is passed to an exit; R. attaching an intravenous spike means to said sterilizing filter exit so that said sterile, non-pyrogenic water for injection may be pumped through said spike means into dry, prepackaged intravenous bags containing measured amounts of medicines for reconstitution; and S. providing a reject valve means for increasing pressure within said filter means by restricting the flow of said contaminated liquid to said drain. 11. The portable intravenous solutions method of claim 10 further comprising the step of providing a remote suction tube means, one end of which is conformed to connect with said inlet end of said tube and one end of which may be placed within a large remote body of liquid for suction thereof. 12. The portable intravenous solutions method of claim 11 wherein the step of providing said reject valve means further comprises the step of providing of a multi-position restriction means so that when liquid quality at said inlet is high, reject flow rate can be reduced to a minimum without undue fouling of said filter means and when liquid quality at said inlet is low, reject flow rate can be increased so as to reduce fouling of said filter means. 13. The portable intravenous solutions method of claim 12 wherein said method produces 300 ml per minute of sterile, non-pyrogenic intravenous solutions and water for injection from drinking water and 20 to 40 liters of said sterile, non-pyrogenic intravenous solutions and water for injection from all sources of water prior to depletion of said filter means. 14. A portable intravenous solutions apparatus comprising; A. a frame B. a pump means mounted on said frame for pumping liquid to be filtered; C. a filter means connected to said pump means so that said liquid discharged from said pump means is forced through said filter means; D. a final stage of said filter means from which sterile water for injection is discharged; E. a hollow box means,of said frame, with a base and top, with a rigid center section to which said pump means and said filter means are attached; F. a handle means, which is part of said rigid center section, across said top of said hollow box means for use as a handle in carrying; G. removably attachable top and sides attached to said base so that easy access to the interior of said box means is attained once said apparatus is placed in operation; and H. a collapsible cranking means attached to said box means for manual operation of said pump means. 15. The portable intravenous solutions apparatus of claim 14 wherein said pump means comprises: A. a shaft connected to said cranking means; B. a roller means attached to said shaft; C. an inlet end of a tube, for transmission of liquid to said filter means, which passes inside said roller means so that when said cranking means turns said shaft, said roller means rhythmically compresses said tube against the housing of said pump means causing a suction at said inlet end of said tube; and D. an outlet end of said tube connected to said filter means. 16. The portable intravenous solutions apparatus of claim 15 further comprising a reservoir tank within said box means, for holding a quantity of liquid, with an outlet port to which said inlet end of said tube may be attached. 17. The portable intravenous solutions apparatus of claim 16 wherein said filter means comprises: A. a combination prefilter and reverse osmosis module in a sealed container wherein said prefilter removes coarse contaminants and said reverse osmosis module passes contaminated liquid to a drain and purified liquid to an exit; B. a carbon column means connected to said exit on said reverse osmosis module so that purified liquid flows therethrough and organic molecules and halogens are removed and purified liquid passes to an exit; and C. an ion exchange column means attached to said carbon column means exit so that purified liquid flows therethrough and ionizable substances are removed and ultrapure water passes to an exit. 18. The portable intravenous solutions apparatus of claim 17 wherein said final stage comprises: A. a sterilizing filter means connected to said exit on said ion exchange means that removes pyrogens and any remaining organics so that sterile, non-pyrogenic intravenous solutions and water for injection are passed to an exit; and B. an intravenous spike means attached to said sterilizing filter exit so that said sterile, non-pyrogenic intravenous solutions and water for injection may be pumped through said spike means into dry, prepackaged intravenous bags containing measured amounts of medicines for reconstitution. 19. The portable intravenous solutions apparatus of claim 18 further comprising a reject valve means for increasing pressure within said filter means by restricting the flow of said contaminated liquid to said drain. 20. The portable intravenous solutions apparatus of claim 19 wherein said reject valve means further comprises a multi-position restriction means so that when liquid quality at said inlet is high, reject flow rate can be reduced to a minimum without undue fouling of said filter means and when liquid quality at said inlet is low, reject flow rate can be increased so as to reduce fouling of said filter means. 21. The portable intravenous solutions apparatus of claim 20 wherein said apparatus produces 300 ml per minute of sterile, non-pyrogenic intravenous solutions and water for injection from drinking water and 20 to 40 liters of said sterile, non-pyrogenic intravenous solutions and water for injection from all sources of water prior to depletion of said filter means. 22. The portable intravenous solutions apparatus of claim 15 further comprising a remote suction tube means, one end of which is conformed to connect with said inlet end of said tube and one end of which may be placed within a remote body of liquid for suction thereof. 23. A portable intravenous solutions apparatus comprising: A. a frame: B. a pump means mounted on said frame for pumping liquid to be filtered; C. a filter means connected to said pump means so that said liquid discharged from said pump means is forced through said filter means; D. a final stage of said filter means from which sterile water for injection is discharged; E. said frame further comprising a hollow box means with a base and a top, with a rigid center section to which said pump means and said filter means are attached; F. a handle means, which is part of said rigid center section, across said top of said hollow box means for use as a handle in carrying; G. removably attachable sides attached to said base so that easy access to the interior of said box means is attained once said apparatus is placed in operation; H. a collapsible cranking means attached to said box means for manual operation of said pump means; I. said pump means further comprising a shaft connected to said cranking means; J. a roller means attached to said shaft; K. an inlet end of a tube, for transmission of liquid to said filter means, which passes inside said roller means so that when said cranking means turns said shaft, said roller means rythmically compresses said tube against the housing of said pump means causing a suction at said inlet end of said tube; L. an outlet end of said tube connected to said filter means; M. a reservoir tank within said box means, for holding a quantity of liquid, with an outlet port to which said inlet end of said tube may be attached; N. said filter means further comprising a combination prefilter and reverse osmosis module in a sealed container wherein said prefilter removes coarse contaminants and said reverse osmosis module passes contaminated liquid to a drain and purified liquid to an exit; O. a carbon column means connected to said exit on said reverse osmosis module so that purified liquid flows therethrough and organic molecules and halogens are removed and purified liquid passes to an exit; P. an ion exchange column means attached to said carbon column means exit so that purified liquid flows therethrough and ionizable substances are removed and ultrapure water passes to an exit; Q. said final stage further comprising a sterilizing filter means connected to said exit on said ion exchange means that removes pyrogens and any remaining organics so that sterile, non-pyrogenic water for injection is passed to an exit; R. an intravenous spike means attached to said sterilizing filter exit so that said sterile, non-pyrogenic water for injection may be pumped through said spike means into dry, prepackaged intravenous bags containing measured amounts of medicines for reconstitution; and S. a reject valve means for increasing pressure within said filter means by restricting the flow of said contaminated liquid to said drain. 24. The portable intravenous solutions apparatus of claim 23 further comprising a remote suction tube means, one end of which is conformed to connect with said inlet end of said tube and one end of which may be placed within a remote body of liquid for suction thereof. 25. The portable intravenous solutions apparatus of claim 24 wherein said reject valve means further comprises a multi-position restriction means so that when liquid quality at said inlet is high, reject flow rate can be reduced to a minimum without undue fouling of said filter means and when liquid quality at said inlet is low, reject flow rate can be increased so as to reduce fouling of said filter means. 26. The portable intravenous solutions apparatus of claim 25 wherein said apparatus produces 300 ml per minute of sterile, non-pyrogenic intravenous solutions and water for injection from drinking water and 20 to 40 liters of said sterile, non-pyrogenic intravenous solutions and water for injection from all sources of water prior to depletion of said filter means.

Details for Patent 4,810,388

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006		2039-09-23