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Last Updated: April 26, 2024

Claims for Patent: 4,783,412

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Summary for Patent: 4,783,412

Title:	Hybrid DNA synthesis of epidermal growth factor
Abstract:	DNA sequences and methods of obtaining DNA sequences which include a sequence encoding for mammalian epidermal growth factor are provided. The DNA sequences may be used in cloning and expression vectors for production of DNA and RNA and for producing polypeptides including mammalian epidermal growth factor. E. coli strains HB 101 (pmegf1) and HB 101 (pmegf10b), and bacteriophage .lambda.hEGF34 were deposited at the A.T.C.C. on May 10, 1983 and given Accession Nos. 39357, 39358 and 40070, respectively.
Inventor(s):	Bell; Graeme I. (San Francisco, CA)
Assignee:	Chiron Corporation (Emeryville, CA)
Application Number:	07/058,706
Patent Claims:	1. A composition comprising DNA molecules containing a nucleotide sequence encoding human epidermal growth factor (EGF) and substantially free of DNA molecules that do not contain said nucleotide sequence, said EGF-encoding nucleotide sequence comprising: ##STR2## 2. The composition of claim 1 whrein said DNA molecules are episomal elements. 3. A composition comprising cells containing an intron free DNA sequence encoding human epidermal growth factor (EGF) substantially free of cells not containing said EGF-encoding DNA sequence, said EGF-encoding DNA sequence comprising: ##STR3## 4. The composition of claim 3 wherein said cells are bacteria. 5. The composition of claim 3 wherein said cells are yeast.

Details for Patent 4,783,412

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2006-01-24
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2006-01-24
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2006-01-24
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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