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Last Updated: April 26, 2024

Claims for Patent: 4,524,065

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Summary for Patent: 4,524,065

Title:	Method for the prevention and treatment of scars with enzymes
Abstract:	A method for the prevention of and for the dissolution of mammalian cicatrices such as acne scars, keloids and other hypertrophic scars comprising intralesional injection of effective amounts of a pharmacologically suitable solution of the enzyme collagenase, by itself, and collagenase in combination with the enzyme hyaluronidase.
Inventor(s):	Pinnell; Sheldon R. (Durham, NC)
Assignee:	Bio-Specifics N.V. (Curacao, AN)
Application Number:	06/520,203
Patent Claims:	1. A method for the dissolution of mammalian cicatrices which comprises administering an effective amount of the enzyme collagenase directly into the lesion. 2. The method of claim 1 wherein the collagenase is a culture of a special strain of clostridium histolyticum chromatographically purified to be free of detectable protease activity. 3. The method of claim 1 wherein the collagenase is administered in the range of 50 to 500 units. 4. The method of claim 1 wherein the collagenase is administered in a series of intralesional injections at spaced time intervals. 5. The method of claim 1 wherein the cicatrix is a keloid. 6. The method of claim 1 wherein the cicatrix is a hypertrophic scar. 7. The method of claim 1 wherein the cicatrix is an acne scar. 8. The method of claim 1 wherein the cicatrix is a depressed scar. 9. The method of claim 1 wherein the cicatrix is a wrinkle. 10. The method of claim 1 wherein the cicatrix is cellulite. 11. The method of claim 1 wherein the cicatrix is neoplastic fibrosis. 12. A method for the dissolution of mammalian cicatrices which comprises administering an effective amount of the enzyme collagenase in combination with an effective amount of the enzyme hyaluronidase directly into the lesion. 13. The method of claim 12 wherein the collagenase is administered in the range of 50 to 500 units in combination with hyaluronidase in the range of 25 to 250 units. 14. The method of claim 12 wherein the cicatrix is a keloid. 15. The method of claim 12 wherein the cicatrix is a hypertrophic scar. 16. The method of claim 12 wherein the cicatrix is an acne scar. 17. The method of claim 12 wherein the cicatrix is a depressed scar. 18. The method of claim 12 wherein the cicatrix is a wrinkle. 19. The method of claim 12 wherein the cicatrix is cellulite. 20. The method of claim 12 wherein the cicatrix is neoplastic fibrosis. 21. A method for the prevention of mammalian cicatrices which comprises administering an effective amount of the enzyme collagenase directly into the affected area during the healing process. 22. The method of claim 21 wherein the collagenase is administered in the range of 50 to 500 units. 23. A method for the prevention of mammalian cicatrices which comprises administering an effective amount of the enzyme collagenase in combination with an effective amount of the enzyme hyaluronidase directly into the affected area during the healing process. 24. The method of claim 23 wherein the collagenase is administered in the range of 50 to 500 units in combination with hyaluronidase in the range of 25 to 250 units.

Details for Patent 4,524,065

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Bausch & Lomb Incorporated	VITRASE	hyaluronidase	Injection	021640	05/05/2004	⤷ Try a Trial	2039-03-29
Bausch & Lomb Incorporated	VITRASE	hyaluronidase	Injection	021640	12/02/2004	⤷ Try a Trial	2039-03-29
Amphastar Pharmaceuticals, Inc.	AMPHADASE	hyaluronidase	Injection	021665	10/26/2004	⤷ Try a Trial	2039-03-29
Akorn, Inc.	HYDASE	hyaluronidase	Injection	021716	10/25/2005	⤷ Try a Trial	2039-03-29
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2039-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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