Claims for Patent: 4,509,861

Summary for Patent: 4,509,861

Title:	Method of mixing one substance with another substance
Abstract:	The invention refers to a method of mixing, for example, cytostatica stored in an ampule (1) provided with a rubber closure (8) or corresponding closure, with, for example, sterile water stored in a second ampule (2) provided with a rubber closure (12) or corresponding closure. The invention is characterized in that a first tube (7) of hypodermic needle shape, which is connected by a hose connection (6) to a first port (5) of a multi-way valve (4), is pierced through the rubber closure (8) of one ampule (1), that a second tube (11) of hypodermic needle shape, which is connected by a hose connection (10) to a second port (9) of the multi-way valve (4), is pierced through the rubber closure (12) of said second ampule (2). The interior of the ampules is interconnected by a hose connection (13), the two respective ends of which have the shape of hypodermic needles (14,15) and are pierced each through one rubber closure (8,12). A pump means in the form of a self-expanding bellows (23) or hypodermic syringe (17) is connected to a third port (16) of the multi-way valve (4). By said pump means (17,23) and alternating adjustment of the multi-way valve (4), the substance in one ampule (2) is transferred to the second ampule (1), in which the two substances are mixed with each other, and the mixture is sucked into the pump means (17,23).
Inventor(s):	Sjonell; Goran (S-181 46 Lidingo, SE)
Assignee:
Application Number:	06/461,547
Patent Claims:	1. A method of mixing one substance stored in a first container provided with first closure means with a second substance stored in a second container provided with second closure means, the method comprising the steps of: (a) communicating interior portions of said first container with a first port of a multi-way valve; (b) communicating interior portions of said second container below the level of said second substance with a second port of said multi-way valve; (c) connecting venting conduit means between said interior portions of said first and second containers through said first and second closure means; (d) connecting pump means to a third port of said multi-way valve; (e) adjusting said valve to connect said second and third ports and actuating said pump means to draw some of said second substance into said pump means; (f) adjusting said valve to close the connection between said second and third ports and to connect said first and third ports and pumping said some of said second substance from said pump means into said first container in mixture with said first substance; (g) repeating steps (e) and (f) until all of said second substance has been pumped into said first container and has been mixed with said first substance to form a mixture; and (h) with said valve adjusted to connect said first and third ports, sucking said mixture into said pump means. 2. A method as defined in claim 1, characterized in that a connection is connected to a fourth port of the multi-way valve, which connection can be connected to an infusion unit, whereby the mixture can be transferred directly via the pump means and multi-way valve to the infusion unit. 3. A method as defined in claim 1, characterized in that a connection is connected to a fourth port of the multi-way valve, which connection can be connected to a cannula, whereby the mixture can be transferred directly via the pump means and multi-way valve to the patient. 4. A method as defined in claim 1, 2 or 3, characterized in that the pump means receiving the mixture consists of a hypodermic syringe having an opening, which syringe may be moved from said third port to and with its opening inserted into a sealing cap attached to structure at the side of the third port, said cap closing said opening. 5. A method as defined in claim 4, characterized in that for transporting the syringe subsequent to its filling with the mixture, the sealing cap with the syringe opening inserted therein is removed from its attachment. 6. A method as defined in claim 1, characterized in that the pump means receiving the mixture is a self-expanding bellows, and the mixture is delivered therefrom via a fourth port of the multi-way valve. 7. The method of claim 1, wherein said first substance comprises cytostatica powder, and said second substance is a liquid. 8. The method of claim 7, wherein said liquid comprises sterile water. 9. A method of mixing one substance stored in a first container provided with first closure means with a second substance stored in a second container provided with second closure means, the method comprising the steps of: (a) communicating interior portions of said first container with a first port of a multi-way valve; (b) communicating interior portions of said second container below the level of said second substance with a second port of said multi-way valve; (c) venting said interior portions of said first and second containers through said first and second closure means; (d) connecting pump means to a third port of said multi-way valve; (e) adjusting said valve to connect said second and third ports and actuating said pump means to draw some of said second substance into said pump means; (f) adjusting said valve to close the connection between said second and third ports and to connect said first and third ports and pumping said some of said second substance from said pump means into said first container in mixture with said first substance; (g) repeating steps (e) and (f) until all of said second substance has been pumped into said first container and has been mixed with said first substance to form a mixture; and (h) with said valve adjusted to connect said first and third ports, sucking said mixture into said pump means.

Details for Patent 4,509,861

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006		2039-09-23